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Design of micro biopsy device for wireless autonomous endoscope

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Abstract

Well-established technology that provides assistance from outside the patient may soon give way to alternative approaches that by the wireless robotic mechanisms inside the patient through natural orifices. For this study, two kinds of micro biopsy mechanisms were developed for capsule endoscope which could traverse the gut environment automatically. This mobility allows the biopsy device to move to the area of interest to sample specific tissues. Based on the medical and mechanism considerations, we concerned on design precise biopsy jaw with sufficient cutting force, and the biopsy process should be safe, repeatable and visible. The lead-screw linkage system that actuated jaw of biopsy allowing for large force production. Using one micro-motor, the biopsy process was carried out quickly by three motions: stretching to sampling point; bite and cutting off; withdrawing into capsule body with the sample. With the control and vision system, the biopsy process could compete automatically. The robot was capable of traversing in the gut environment wirelessly and had been successfully used to biopsy gut tissue in vitro. In addition, experimental analysis of the biopsy mechanism showed good results towards more elaborate tissue manipulation in the future.

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References

  1. Iddan, G., Meron, G., Glukhovsky, A., and Swain, P., “Wireless Capsule Endoscopy,” Nature, Vol. 405, Page No. 417, 2000.

    Article  Google Scholar 

  2. Metzger, Y. C., Adler, S. N., Shitrit, A., Koslowsky, B., and Bjarnason, I., “Comparison of a New Pillcam™ SB2 Video Capsule Versus the Standard Pillcam™ SB for Detection of Small Bowel Disease,” Reports in Medical Imaging, Vol. 2, No. 1, pp. 7–11, 2009.

    Google Scholar 

  3. Gheorghe, C., Iacob, R., and Bancila, I., “Olympus Capsule Endoscopy for Small Bowel Examination,” Journal of Gastrointestinal and Liver Diseases, Vol. 16, No. 3, Page No. 309, 2007.

    Google Scholar 

  4. Bo, S. H., Han, J., Woo, C. W., Jin, H. J., Kim, B. H., et al., “Method for Processing an Image in Capsule Endoscope System and Capsule Endoscope System, Capable of Compensating Dark Current Generated from a Photographed Image and Noises Due to Heat,” KR Patent, No. 1020070106275, 2007.

    Google Scholar 

  5. Jinshan Sciencs & Technology, “OMOM Capsule Endoscopic System,” http://english.jinshangroup.com/index.php/Index/product/id/3.html (Accessed 17 OCT 2014)

    Google Scholar 

  6. Rasouli, M., Lin, L., Kencana, A. P., Wong, K. J., Tan, S. L., et al., “Therapeutic Capsule Endoscopy: Opportunities and Challenges,” Journal of Healthcare Engineering, Vol. 2, No. 4, pp. 459–471, 2011.

    Article  Google Scholar 

  7. Byun, S., Lim, J. M., Paik, S. J., Lee, A., Koo, K. I., et al., “Barbed Micro-Spikes for Micro-Scale Biopsy,” Journal of Micromechanics and Microengineering, Vol. 15, No. 6, Page No. 1279, 2005.

    Article  Google Scholar 

  8. Kim, G., Park, S., Koo, K. i., Choi, H. M., Jung, M. J., et al., “Nickel MicroSpike for MicroScale Biopsy using LIGA Process,” Proc. of 9th International Conference on Synchrotron Radiation Instrumentation, pp. 1499–1502, 2007.

    Google Scholar 

  9. Crosby, W. H., Army, U., and Kugler, H. W., “Intraluminal Biopsy of the Small Intestine,” The American Journal of Digestive Diseases, Vol. 2, No. 5, pp. 236–241, 1957.

    Article  Google Scholar 

  10. Park, S., Koo, K. I., Bang, S. M., Park, J. Y., and Song, S. Y., “A Novel Microactuator for Microbiopsy in Capsular Endoscopes,” Journal of Micromechanics and Microengineering, Vol. 18, No. 2, Paper No. 025032, 2008.

    Google Scholar 

  11. Kong, K. C., Cha, J., Jeon, D., and Cho, D. I., “A Rotational Micro Biopsy Device for the Capsule Endoscope,” Proc. of IEEE/RSJ International Conference on Intelligent Robots and Systems, pp. 1839–1843, 2005.

    Google Scholar 

  12. Valdastri, P., Simi, M., and Webster, R. J., “Advanced Technologies for Gastrointestinal Endoscopy,” Annual Review of Biomedical Engineering, Vol. 14, No. 1, pp. 397–429, 2012.

    Article  Google Scholar 

  13. Simi, M., Gerboni, G., Menciassi, A., and Valdastri, P., “Magnetic Mechanism for Wireless Capsule Biopsy,” Journal of Medical Devices, Vol. 6, No. 1, Paper No. 017611, 2012.

    Article  Google Scholar 

  14. Kim, B., Park, S., and Park, J.-O., “Microrobots for a Capsule Endoscope,” Proc. of IEEE/ASME International Conference on Advanced Intelligent Mechatronics, pp. 729–734, 2009.

    Google Scholar 

  15. Wang, K., Yan, G., Jiang, P., and Ye, D., “A Wireless Robotic Endoscope for Gastrointestine,” IEEE Transactions on Robotics, Vol. 24, No. 1, pp. 206–210, 2008.

    Article  Google Scholar 

  16. Arena, P., Bonomo, C., Fortuna, L., Frasca, M., and Graziani, S., “Design and Control of an IPMC Wormlike Robot,” IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics, Vol. 36, No. 5, pp. 1044–1052, 2006.

    Article  Google Scholar 

  17. Valdastri, P., Webster, R. J., Quaglia, C., Quirini, M., Menciassi, A., and Dario, P., “A New Mechanism for Mesoscale Legged Locomotion in Compliant Tubular Environments,” IEEE Transactions on Robotics, Vol. 25, No. 5, pp. 1047–1057, 2009.

    Article  Google Scholar 

  18. Quirini, M., Menciassi, A., Scapellato, S., Stefanini, C., and Dario, P., “Design and Fabrication of a Motor Legged Capsule for the Active Exploration of the Gastrointestinal Tract,” IEEE/ASME Transactions on Mechatronics, Vol. 13, No. 2, pp. 169–179, 2008.

    Article  Google Scholar 

  19. Quaglia, C., Buselli, E., Webster III, R. J., Valdastri, P., Menciassi, A., and Dario, P., “An Endoscopic Capsule Robot: A Meso-Scale Engineering Case Study,” Journal of Micromechanics and Microengineering, Vol. 19, No. 10, Paper No. 105007, 2009.

    Article  Google Scholar 

  20. Palagi, S., Pensabene, V., Beccai, L., Mazzolai, B., Menciassi, A., and Dario, P., “Design and Development of a Soft Magnetically-Propelled Swimming Microrobot,” Proc. of IEEE International Conference on Robotics and Automation, pp. 5109–5114, 2011.

    Google Scholar 

  21. Simi, M., Valdastri, P., Quaglia, C., Menciassi, A., and Dario, P., “Design, Fabrication, and Testing of a Capsule with Hybrid Locomotion for Gastrointestinal Tract Exploration,” IEEE/ASME Transactions on Mechatronics, Vol. 15, No. 2, pp. 170–180, 2010.

    Article  Google Scholar 

  22. Ciuti, G., Donlin, R., Valdastri, P., Arezzo, A., Menciassi, A., et al., “Robotic Versus Manual Control in Magnetic Steering of an Endoscopic Capsule,” Endoscopy, Vol. 42, No. 2, pp. 148–152, 2010.

    Article  Google Scholar 

  23. Lee, J. S., Kim, B., and Hong, Y. S., “A Flexible Chain-based Screw Propeller for Capsule Endoscopes,” Int. J. Precis. Eng. Manuf., Vol. 10, No. 4, pp. 27–34, 2009.

    Article  MathSciNet  Google Scholar 

  24. Gao, P., Yan, G., Wang, Z., Wang, K., Jiang, P., and Zhou, Y., “A Robotic Endoscope based on Minimally Invasive Locomotion and Wireless Techniques for Human Colon,” The International Journal of Medical Robotics and Computer Assisted Surgery, Vol. 7, No. 3, pp. 256–267, 2011.

    Google Scholar 

  25. Greenish, S., Hayward, V., Chial, V., Okamura, A., and Steffen, T., “Measurement, Analysis, and Display of Haptic Signals during Surgical Cutting,” Presence: Teleoperators and Virtual Environments, Vol. 11, No. 6, pp. 626–651, 2002.

    Article  Google Scholar 

  26. Crosby, W. H., Army, U., and Kugler, H. W., “Intraluminal Biopsy of the Small Intestine,” The American Journal of Digestive Diseases, Vol. 2, No. 5, pp. 236–241, 1957.

    Article  Google Scholar 

  27. Rockey, D. C., Stephen, H. C., Zachary, D. G., Rendon, C. N., and Alastair, D. S., “Liver Biopsy,” Hepatology, Vol. 49, No. 3, pp. 1017–1044, 2009.

    Article  Google Scholar 

  28. Jia, Z., Yan, G., Liu, H., Wang, Z., Jiang, P., and Shi, Y., “The Optimization of Wireless Power Transmission: Design and Realization,” The International Journal of Medical Robotics and Computer Assisted Surgery, Vol. 8, No. 3, pp. 337–347, 2012.

    Article  Google Scholar 

  29. Ma, G. and Yan, G., “Wireless Powered Microrobot for Gastrointestinal Detection,” Proc. of International Conference on Mechatronics and Automation, pp. 1085–1089, 2007.

    Google Scholar 

  30. Chen, W. W., Yan, G. Z., Gao, P., and Wang, Z. W., “Control System Design of Micro Diagnosis and Treating Robot for Colonoscopy,” Optics and Precision Engineering, Vol. 20, No. 6, pp. 1296–1302, 2012.

    Article  Google Scholar 

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Authors and Affiliations

  1. Shanghai Engineering Center for Microsatellite (SECM), Chinese Academy of Science, Haike Road 99, Pudong District, Shanghai, China, 201203

    Wen-Wen Chen

  2. School of Electronic Information and Electrical Engineering, Shanghai Jiaotong University, 800, DongChuan-road, Shanghai, China, 200240

    Guo-Zheng Yan, Hua Liu, Ping-Ping Jiang & Zhi-Wu Wang

Authors
  1. Wen-Wen Chen
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  2. Guo-Zheng Yan
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  3. Hua Liu
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  4. Ping-Ping Jiang
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  5. Zhi-Wu Wang
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Correspondence to Wen-Wen Chen.

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Chen, WW., Yan, GZ., Liu, H. et al. Design of micro biopsy device for wireless autonomous endoscope. Int. J. Precis. Eng. Manuf. 15, 2317–2325 (2014). https://doi.org/10.1007/s12541-014-0596-2

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  • DOI: https://doi.org/10.1007/s12541-014-0596-2

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