The disordered charged biased proteins in the human diseasome

Abstract

Intrinsically disordered proteins (IDPs) are often involved in diseases and have been shown to be promising targets for drug development. Here, we focus on the human disordered charged biased proteins (HDCBPs). We have investigated the association of the HDCBPs with diseases by integrating various sources that cover public sources of gene–disease associations and intensive literature mining. The results indicate that 95% of HDCBPs are associated with multiple diseases, including mainly various cancers, nervous, endocrine, immune, hematological, and respiratory systems diseases. Our data show that the HDCBP–disease network constructed by integrating different levels of data together may improve our understanding of these complex diseases. Moreover, we present the top-ranked proteins that might be potential markers for diagnostic and drug targets.

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Acknowledgements

This work was supported by the Ministry of Higher Education and Scientific Research, Tunisia.

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Correspondence to Mouna Choura.

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Choura, M., Rebaï, A. The disordered charged biased proteins in the human diseasome. Interdiscip Sci Comput Life Sci 12, 44–49 (2020). https://doi.org/10.1007/s12539-019-00315-0

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Keywords

  • Charged biased proteins
  • Disease association
  • Drugs
  • Therapeutic target