Intrinsically disordered proteins (IDPs) are often involved in diseases and have been shown to be promising targets for drug development. Here, we focus on the human disordered charged biased proteins (HDCBPs). We have investigated the association of the HDCBPs with diseases by integrating various sources that cover public sources of gene–disease associations and intensive literature mining. The results indicate that 95% of HDCBPs are associated with multiple diseases, including mainly various cancers, nervous, endocrine, immune, hematological, and respiratory systems diseases. Our data show that the HDCBP–disease network constructed by integrating different levels of data together may improve our understanding of these complex diseases. Moreover, we present the top-ranked proteins that might be potential markers for diagnostic and drug targets.
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This work was supported by the Ministry of Higher Education and Scientific Research, Tunisia.
Conflict of interest
The authors declare that they have no conflict of interest.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Supplemental file: HDCBP–disease associations. It contains in four worksheets. (1) KR proteins including Uniprot ID, number of associated diseases, PubMed IDs, and Opentargets cross-reference. (2) DE proteins including Uniprot ID, number of associated diseases, PubMed IDs, and Opentargets cross-reference. (3) Diseases associated with KR proteins. (4) Diseases associated with DE proteins (XLSX 509 KB)
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Choura, M., Rebaï, A. The disordered charged biased proteins in the human diseasome. Interdiscip Sci Comput Life Sci 12, 44–49 (2020). https://doi.org/10.1007/s12539-019-00315-0
- Charged biased proteins
- Disease association
- Therapeutic target