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Wirkung einer Nahrungsergänzung auf Basis von Enzym–Hefezellen auf den oxidativen Stress bei klinisch gesunden Personen

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Sport- und Präventivmedizin

Rationale

Dietary strategies to sustain antioxidative capacity are often inadequately evaluated. We have tested the influence of a yeast–cells–based supplement on the blood concentration of free radicals.

Methods

11 healthy subjects (5 males, 6 females, 20 to 50 yrs) were examined before and after 4–weeks intervention with a daily 30 ml dosage of a bioactive yeast–cells preparation (Dr. Wolz Zell Immunkomplex®). Free radicals were measured in the morning at a 240 min time interval by electron–spin–spectroscopy (Fa. Bruker, Rheinstetten, Germany).

Results

All participants completed the study without side effects. After intervention free radicals were lowered (p < 0.01) and decreased acutely after drinking the test dosage (1.72 ± 0.19 vs. 2.04 ± 0.37) at about 20% .

Conclusions

The method used objectifies significant adaptations after intake of the bioactive supplement. The intake of the complex induces an adjustment of the antioxidant regulations. This modulation may be of specific interest in health care and complementary therapy of chronic degenerative diseases.

Rationales

Vorgaben, mit denen über Ernährungsansätze auf die Regulation der antioxidativen Kapazität Einfluss genommen werden soll, sind meist nur unzureichend über methodische Verfahren abgesichert. In der vorliegenden Studiewurde der Einfluss eines Nahrungssupplements auf Basis von Hefezellen auf die Blutkonzentration der freien Radikale beobachtet.

Methoden

Hierzu wurden 11 klinisch gesunde Personen (5 Männer und 6 Frauen im Alter von 20 bis 50 Jahren) vor und nach einer 4-wöchigen Intervention mit einem bioaktiven Supplement (morgendlicher Verzehr von 30 ml Dr. Wolz Zell Immunkomplex®) untersucht. Zur Beurteilung der aktuellen oxidativen Stresssituation wurde zu 3 Untersuchungszeitpunkten über einen Zeitraum von 240 Minuten nach Verzehr des Supplements die Blutkonzentration der freien Radikale mittels Elektronen-Spin-Spektroskopie (Fa. Bruker, Rheinstetten, Deutschland) analysiert.

Ergebnisse

Alle Probanden beendeten die Studie ohne Beobachtung von Nebenwirkungen. Nach der Intervention messen sich die freien Radikale zu allen Messzeitpunkten erniedrigt (p < 0.01); mit einer Absenkung um ca. 20% gegenüber dem Basiswert wird für die freien Radikale die niedrigste Blutkonzentration 240 Minuten nach Trinken des Supplements erreicht (1.72 ± 0.19 vs. 2.04 ± 0.37).

Schlussfolgerungen

Mit der benutzten Methode ist es möglich, einen signifikanten Einfluss des getesteten bioaktiven Immunkomplexes auf die Blutkonzentration der freien Radikale nachzuweisen. So führt der Verzehr des Supplements zu einem Absenken der Radikalkonzentration und einer möglichen Anpassung der antioxidativen Regulation. Die nachgewiesene Wirkung kann für die Gesundheitsvorsorge wie auch für eine begleitende Therapie von chronisch degenerativen Erkrankungen von Bedeutung sein.

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Authors and Affiliations

  1. Universitätsklinikum Freiburg Abt. Präventive und Rehabilitative Sportmedizin, Hugstetter Str. 55, D–79106, Freiburg, Germany

    P Deibert, D König, D Schaffner & A Berg

  2. Institut für Präventive Medizin (IPM®), Freiburg, Germany

    P Deibert, D König, A Stensitzky-Thielemans & A Berg

  3. Institut für Sport und Sportwissenschaften, Bereich Ernährung, Universität Freiburg, Freiburg, Germany

    D König, A Stensitzky-Thielemans & A Berg

  4. Bruker BioSpin GmbH, Medical and Pharmaceutical Applications, Rheinstetten, Germany

    B Fink

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  1. P Deibert
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  2. D König
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  4. A Stensitzky-Thielemans
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  5. B Fink
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  6. A Berg
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Additional information

Effect of a dietary supplement based on enzyme yeast cells to oxidative stress in clinically healthy individuals

Eingegangen am 28.03.2011, angenommen am 16.05.2011

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Deibert, P., König, D., Schaffner, D. et al. Wirkung einer Nahrungsergänzung auf Basis von Enzym–Hefezellen auf den oxidativen Stress bei klinisch gesunden Personen. Sportmed Präventivmed 41, 17–23 (2011). https://doi.org/10.1007/s12534-011-178-3

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