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Temporal Links Between Self-Reported Sleep and Antibody Responses to the Influenza Vaccine

  • Special Issue: Sleep Science
  • Published:
International Journal of Behavioral Medicine Aims and scope Submit manuscript

Abstract

Background

Growing evidence suggests that sleep plays an important role in immunological memory, including antibody responses to vaccination. However, much of the prior research has been carried out in the laboratory limiting the generalizability of the findings. Furthermore, no study has sought to identify sensitive periods prior to or after vaccination where sleep may have a stronger influence on antibody responses.

Methods

Eighty-three healthy young adults completed 13 days of sleep diaries and received the trivalent influenza vaccine on day 3 of the study. Measures of self-reported sleep duration, sleep efficiency, and subjective sleep quality were assessed on each day. Antibody levels to the influenza viral strains were quantified at baseline and 1 and 4 months following influenza vaccination.

Results

Shorter sleep duration, averaged over the collection period, was associated with fewer antibodies to the A/New Caledonia viral strain 1 and 4 months later, independent of baseline antibodies, age, sex, and cohort year. Analyses focused on nightly sleep on the days preceding and after the vaccination revealed that shorter sleep duration on the two nights before the vaccination predicted fewer antibodies 1 and 4 months later. Measures of self-reported sleep efficiency and subjective quality were unrelated to antibody responses to the influenza vaccination.

Conclusion

These findings provide further support for an association between sleep duration and antibody responses to the influenza vaccine and suggest that perhaps sleep on nights prior to vaccination are critical. If replicated, these findings may support sleep as a target for enhancing vaccination efficacy.

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Notes

  1. Associations were also not statistically significant when B/Yamanashi and B/Victoria strains were examined separately.

References

  1. Disease Burden of Influenza | CDC: 2019. www.cdc.gov/flu/about/burden/index.html.

  2. Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12:36–44. https://doi.org/10.1016/S1473-3099(11)70295-X.

    Article  Google Scholar 

  3. Prather AA, Leung CW. Association of insufficient sleep with respiratory infection among adults in the United States. JAMA Intern Med. 2016;176:850–2. https://doi.org/10.1001/jamainternmed.2016.0787.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016;80:40–52. https://doi.org/10.1016/j.biopsych.2015.05.014.

    Article  PubMed  Google Scholar 

  5. Solarz DE, Mullington JM, Meier-Ewert HK. Sleep, inflammation and cardiovascular disease. Front Biosci Elite Ed. 2012;4:2490–501. https://doi.org/10.2741/e560.

    Article  PubMed  Google Scholar 

  6. Besedovsky L, Lange T, Born J. Sleep and immune function. Pflugers Arch. 2012;463:121–37. https://doi.org/10.1007/s00424-011-1044-0.

    Article  CAS  PubMed  Google Scholar 

  7. Born J, Lange T, Hansen K, et al. Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol Baltim Md 1950. 1997;158:4454–64.

    CAS  Google Scholar 

  8. Benedict C, Brytting M, Markström A, Broman JE, Schiöth HB. Acute sleep deprivation has no lasting effects on the human antibody titer response following a novel influenza A H1N1 virus vaccination. BMC Immunol. 2012;13:1. https://doi.org/10.1186/1471-2172-13-1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lange T, Perras B, Fehm HL, Born J. Sleep enhances the human antibody response to hepatitis A vaccination. Psychosom Med. 2003;65:831–5. https://doi.org/10.1097/01.psy.0000091382.61178.f1.

    Article  PubMed  Google Scholar 

  10. Lange T, Dimitrov S, Bollinger T, et al. Sleep after vaccination boosts immunological memory. J Immunol Baltim Md 1950. 2011;187:283–90. https://doi.org/10.4049/jimmunol.1100015.

    Article  CAS  Google Scholar 

  11. Spiegel K, Sheridan JF, Van Cauter E. Effect of sleep deprivation on response to immunization. JAMA. 2002;288:1471–2. https://doi.org/10.1001/jama.288.12.1471-a.

    Article  PubMed  Google Scholar 

  12. Prather AA, Hall M, Fury JM, Ross DC, Muldoon MF, Cohen S, et al. Sleep and antibody response to hepatitis B vaccination. Sleep. 2012;35:1063–9. https://doi.org/10.5665/sleep.1990.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Cohen S, Doyle WJ, Alper CM, Janicki-Deverts D, Turner RB. Sleep habits and susceptibility to the common cold. Arch Intern Med. 2009;169:62–7. https://doi.org/10.1001/archinternmed.2008.505.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Taylor DJ, Kelly K, Kohut ML, Song K-S. Is insomnia a risk factor for decreased influenza vaccine response? Behav Sleep Med. 2017;15:270–87. https://doi.org/10.1080/15402002.2015.1126596.

    Article  PubMed  Google Scholar 

  15. Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16:626–38. https://doi.org/10.1038/nri.2016.90.

    Article  CAS  PubMed  Google Scholar 

  16. Klein SL, Hodgson A, Robinson DP. Mechanisms of sex disparities in influenza pathogenesis. J Leukoc Biol. 2012;92:67–73. https://doi.org/10.1189/jlb.0811427.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Scepanovic P, Alanio C, Hammer C, Hodel F, Bergstedt J, Patin E, et al. Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines. Genome Med. 2018;10:59. https://doi.org/10.1186/s13073-018-0568-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Pedersen AF, Zachariae R, Bovbjerg DH. Psychological stress and antibody response to influenza vaccination: a meta-analysis. Brain Behav Immun. 2009;23:427–33. https://doi.org/10.1016/j.bbi.2009.01.004.

    Article  CAS  PubMed  Google Scholar 

  19. Burns VE, Carroll D, Drayson M, Whitham M, Ring C. Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults. J Psychosom Res. 2003;55:569–72. https://doi.org/10.1016/s0022-3999(03)00073-4.

    Article  PubMed  Google Scholar 

  20. Pressman SD, Cohen S, Miller GE, et al. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol Off J Div Health Psychol Am Psychol Assoc. 2005;24:297–306. https://doi.org/10.1037/0278-6133.24.3.297.

    Article  Google Scholar 

  21. Miller GE, Cohen S, Pressman S, Barkin A, Rabin BS, Treanor JJ. Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Psychosom Med. 2004;66:215–23. https://doi.org/10.1097/01.psy.0000116718.54414.9e.

    Article  PubMed  Google Scholar 

  22. Kalmbach DA, Anderson JR, Drake CL. The impact of stress on sleep: pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders. J Sleep Res. 2018;27:e12710. https://doi.org/10.1111/jsr.12710.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Gordon AM, Del Rosario K, Flores AJ, et al. Bidirectional links between social rejection and sleep. Psychosom Med. 2019;81:739–48. https://doi.org/10.1097/PSY.0000000000000669.

    Article  PubMed  Google Scholar 

  24. Cacioppo JT, Hawkley LC, Berntson GG, Ernst JM, Gibbs AC, Stickgold R, et al. Do lonely days invade the nights? Potential social modulation of sleep efficiency. Psychol Sci. 2002;13:384–7. https://doi.org/10.1111/1467-9280.00469.

    Article  PubMed  Google Scholar 

  25. Kurina LM, Knutson KL, Hawkley LC, Cacioppo JT, Lauderdale DS, Ober C. Loneliness is associated with sleep fragmentation in a communal society. Sleep. 2011;34:1519–26. https://doi.org/10.5665/sleep.1390.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Monk TH, Reynolds CF, Kupfer DJ, Buysse DJ, Coble PA, Hayes AJ, et al. The Pittsburgh sleep diary. J Sleep Res. 1994;3:111–20.

    Article  Google Scholar 

  27. Kaufmann L, Syedbasha M, Vogt D, et al. An optimized hemagglutination inhibition (HI) assay to quantify influenza-specific antibody titers. J Vis Exp JoVE. 2017. https://doi.org/10.3791/55833.

  28. Knutson KL, Rathouz PJ, Yan LL, Liu K, Lauderdale DS. Intra-individual daily and yearly variability in actigraphically recorded sleep measures: the CARDIA study. Sleep. 2007;30:793–6. https://doi.org/10.1093/sleep/30.6.793.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Prather AA, Janicki-Deverts D, Hall MH, Cohen S. Behaviorally assessed sleep and susceptibility to the common cold. Sleep. 2015;38:1353–9. https://doi.org/10.5665/sleep.4968.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Prather AA, Janicki-Deverts D, Adler NE, Hall M, Cohen S. Sleep habits and susceptibility to upper respiratory illness: the moderating role of subjective socioeconomic status. Ann Behav Med Publ Soc Behav Med. 2017;51:137–46. https://doi.org/10.1007/s12160-016-9835-3.

    Article  Google Scholar 

  31. Ayling K, Fairclough L, Tighe P, et al. Positive mood on the day of influenza vaccination predicts vaccine effectiveness: a prospective observational cohort study. Brain Behav Immun. 2018;67:314–23. https://doi.org/10.1016/j.bbi.2017.09.008.

    Article  PubMed  Google Scholar 

  32. Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99:1325–80. https://doi.org/10.1152/physrev.00010.2018.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Bollinger T, Bollinger A, Skrum L, Dimitrov S, Lange T, Solbach W. Sleep-dependent activity of T cells and regulatory T cells. Clin Exp Immunol. 2009;155:231–8. https://doi.org/10.1111/j.1365-2249.2008.03822.x.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Dimitrov S, Lange T, Tieken S, et al. Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav Immun. 2004;18:341–8. https://doi.org/10.1016/j.bbi.2003.08.004.

    Article  CAS  PubMed  Google Scholar 

  35. Buysse DJ. Sleep health: can we define it? Does it matter? Sleep. 2014;37:9–17. https://doi.org/10.5665/sleep.3298.

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

This research was supported by a grant from the National Institute of Mental Health (MH50430) and supplemental funding from the John D. and Catherine T. MacArthur Foundation Research Network on Socioeconomic Status and Health. It was facilitated by grants from the National, Heart, Lung, and Blood Institute to the Pittsburgh Mind-Body Center (HL65111 and HL65112). Dr. Prather’s contribution was supported by a grant from the National Heart, Lung, and Blood Institute (HL1420151).

Author information

Author notes

  1. Aric A. Prather and Sarah D. Pressman contributed equally to this work.

Authors and Affiliations

  1. Department of Psychiatry, University of California, San Francisco, CA, USA

    Aric A. Prather

  2. Department of Psychology & Social Behavior, University of California, Irvine, CA, USA

    Sarah D. Pressman

  3. Department of Psychology and Institute for Policy Research, Northwestern University, Evanston, IL, USA

    Gregory E. Miller

  4. Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA

    Sheldon Cohen

Authors
  1. Aric A. Prather
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  2. Sarah D. Pressman
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  3. Gregory E. Miller
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  4. Sheldon Cohen
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Corresponding authors

Correspondence to Aric A. Prather or Sarah D. Pressman.

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Informed consent was obtained from all participants in accordance with the Institutional Review Board where this research was conducted.

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The authors declare that they have no conflicts of interest.

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Prather, A.A., Pressman, S.D., Miller, G.E. et al. Temporal Links Between Self-Reported Sleep and Antibody Responses to the Influenza Vaccine. Int.J. Behav. Med. 28, 151–158 (2021). https://doi.org/10.1007/s12529-020-09879-4

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  • DOI: https://doi.org/10.1007/s12529-020-09879-4

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