International Journal of Behavioral Medicine

, Volume 25, Issue 2, pp 243–251 | Cite as

Validation of an Egyptian Arabic Version of Skindex-16 and Quality of Life Measurement in Egyptian Patients with Skin Disease

  • Nagwa Essa
  • Sara Awad
  • Mariam Nashaat



To translate and cross-culturally adapt the Skindex-16, a brief skin-disease-specific QoL questionnaire, into Arabic for Egyptians and to evaluate its measurement properties in Egyptian patients with skin disease.


Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, Skindex-16 was administered to 500 consecutive dermatological patients and 500 healthy persons for verification of its reliability and validity. Next, we examined the effect of skin disorders on QoL as well as influences of age, sex, socioeconomic level, education, and use of medication on skin disease-related QoL.


The instrument showed high internal consistency reliability and good construct and content validity. The quality of life was most deteriorated in the emotional domain followed by symptoms domain (mean percentage score 55.5 ± 23.1 and 31.7 ± 26.8 respectively), while functioning was the least affected domain (mean percentage score 29.1 ± 26.8). Higher total Skindex-16 scores were observed for patients with psoriasis, urticaria, acne, and atopic dermatitis than those with vitiligo and alopecia areata. Educational level, social class, medication use, and family history influenced the impact of skin disease on overall QoL.


The adapted Egyptian Arabic version of Skindex-16 is valid and reliable; it showed that skin problems had a clinically significant impact on QoL in Egyptian patients.


Skindex-16 Egyptian version Quality of life Skin diseases 



Skindex-16 instrument is used with permission from Dr. M. Chren and Mapi Research Trust, Lyon, France. E-mail:—Internet:

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

“The study has been approved by the local ethical committee of our institution and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.”

Informed Consent

“Informed consent was obtained from all individual participants included in the study.”

Funding Sources

This work is not supported by external funding sources.


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Copyright information

© International Society of Behavioral Medicine 2017

Authors and Affiliations

  1. 1.Department of Dermatology and VenereologyAssiut University HospitalAssiutEgypt

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