Validation of an Egyptian Arabic Version of Skindex-16 and Quality of Life Measurement in Egyptian Patients with Skin Disease
- 120 Downloads
To translate and cross-culturally adapt the Skindex-16, a brief skin-disease-specific QoL questionnaire, into Arabic for Egyptians and to evaluate its measurement properties in Egyptian patients with skin disease.
Translation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, Skindex-16 was administered to 500 consecutive dermatological patients and 500 healthy persons for verification of its reliability and validity. Next, we examined the effect of skin disorders on QoL as well as influences of age, sex, socioeconomic level, education, and use of medication on skin disease-related QoL.
The instrument showed high internal consistency reliability and good construct and content validity. The quality of life was most deteriorated in the emotional domain followed by symptoms domain (mean percentage score 55.5 ± 23.1 and 31.7 ± 26.8 respectively), while functioning was the least affected domain (mean percentage score 29.1 ± 26.8). Higher total Skindex-16 scores were observed for patients with psoriasis, urticaria, acne, and atopic dermatitis than those with vitiligo and alopecia areata. Educational level, social class, medication use, and family history influenced the impact of skin disease on overall QoL.
The adapted Egyptian Arabic version of Skindex-16 is valid and reliable; it showed that skin problems had a clinically significant impact on QoL in Egyptian patients.
KeywordsSkindex-16 Egyptian version Quality of life Skin diseases
Skindex-16 instrument is used with permission from Dr. M. Chren and Mapi Research Trust, Lyon, France. E-mail: PROinformation@mapi-trust.org—Internet: www.proqolid.org
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
“The study has been approved by the local ethical committee of our institution and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.”
“Informed consent was obtained from all individual participants included in the study.”
This work is not supported by external funding sources.
- 11.Comrey LA, Lee HB. A first course in factor analysis. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum Associates; 1992.Google Scholar
- 12.Mokkink LB, Terwee CB, Patrick DL, Alonso J, Stratford PW, Knol DL, et al. The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study. Qual Life Res. 2010;19:539–49.CrossRefPubMedPubMedCentralGoogle Scholar
- 19.Chua SL, Maurer T, Chren MM. Adaptation of a Runyankore version of Skindex-16 for oral administration in Mbarara. Uganda Int J Dermatol. 2011;50:1249–54.Google Scholar
- 26.Kosaraju SKM, Reddy SR, Vadlamani N, Sandhya L, Kalasapati L, Maganti S, et al. Psychological morbidity among dermatological patients in a rural setting. Int J Dermatol. 2015;60:635.Google Scholar
- 31.Grob JJ, Revuz J, Ortonne JP, Auguier P, Lorette G. Comparative study of the impact of chronic urticaria, psoriasis, and atopic dermatitis on the QoL. Int J Dermatol. 2005;152:289–95.Google Scholar
- 33.Mayrshofer F, Herti M, Sinkgraven R, Sticherling M, Pfeiffer C, Zillikens D, et al. Significant decrease in quality of life in patients with pemphigus vulgaris, result from the German bullous skin disease (BSD) study group. J Dtsch Dermatol Ges. 2005;3:431–5.Google Scholar
- 39.Al Robaee AA. Assessment of general health and quality of life in patients with acne using a validated generic questionnaire. Acta Dermatoven Alp Panonica Adriat. 2009;18:157–64.Google Scholar
- 42.Al Robaee AA. Assessment of quality of life in Saudi patients with vitiligo in a medical school in Qassim province. Saudi Arabia Saudi Med J. 2007;28:1414–7.Google Scholar
- 44.Jobanputra R, Bachmann M. The effect of skin diseases on quality of life in patients from different social and ethnic groups in Cape Town. South Africa Int J Dermatol. 2000;39(11):826–31.Google Scholar