Skip to main content
Log in

Mental Distress Factors and Exercise Capacity in Patients with Coronary Artery Disease Attending Cardiac Rehabilitation Program

  • Published:
International Journal of Behavioral Medicine Aims and scope Submit manuscript

Abstract

Purpose

There is still insufficient data on mental distress factors contributing to exercise capacity (EC) improvement before and after cardiac rehabilitation (CR) in patients with coronary artery disease (CAD). The aim of our study was to evaluate the associations between various mental distress factors and EC before and after exercise-based CR (EBCR).

Methods

Over 12 months, 223 CAD patients (70% men, mean age 58 ± 9 years) were evaluated for socio-demographic, clinical, and mental distress symptoms as measured by the Hospital Anxiety and Depression scale (HADS), Beck Depression Inventory-II (BDI-II), and Spielberger State-Trait Anxiety Inventory (STAI). Patients were tested for EC at baseline and after EBCR.

Results

In a multivariate linear regression model, EC before EBCR was associated with HADS anxiety subscale (β = −.186, p = .002) and BDI-II somatic/affective subscale (β = −.249, p < .001). EC after EBCR was associated with HADS anxiety and depression subscales (β = −.198, p < .001; β = −.170, p = .002, respectively) and BDI-II (β = −.258, p < .001). The BDI-II somatic/affective subscale was the best predictor of reduced EC before and after EBCR.

Conclusions

Mental distress and somatic/affective symptoms of depression are strongly associated with EC both at the beginning and after EBCR. Analysis of possible mediating or moderating factors was beyond the scope of our study. Future studies should focus on comprehensive evaluation of EC risk factors including other mental distress characteristics, subjectively experienced fatigue, and post-operative CAD symptoms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Batacan RB Jr, Duncan MJ, Dalbo VJ, Tucker PS, Fenning AS. Effects of light intensity activity on CVD risk factors: a systematic review of intervention studies. Biomed Res Int. 2015;2015:596367. doi:10.1155/2015/596367.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Miller DD, Shaw LJ. Coronary artery disease: diagnostic and prognostic models for reducing patient risk. J Cardiovasc Nurs. 2006;21(6 Suppl 1):S2–16; quiz S7–9.

  3. Yu CM, Lau CP, Cheung BM, Fong YM, Ho YY, Lam KB, et al. Clinical predictors of morbidity and mortality in patients with myocardial infarction or revascularization who underwent cardiac rehabilitation, and importance of diabetes mellitus and exercise capacity. Am J Cardiol. 2000;85(3):344–9.

    Article  CAS  PubMed  Google Scholar 

  4. Monmeneu JV, Chorro FJ, Bodi V, Sanchis J, Llacer A, Garcia-Civera R, et al. Relationships between heart rate variability, functional capacity, and left ventricular function following myocardial infarction: an evaluation after one week and six months. Clin Cardiol. 2001;24(4):313–20.

    Article  CAS  PubMed  Google Scholar 

  5. Balsam P, Glowczynska R, Zaczek R, Szmit S, Opolski G, Filipiak KJ. The effect of cycle ergometer exercise training on improvement of exercise capacity in patients after myocardial infarction. Kardiol Pol. 2013;71(10):1059–64. doi:10.5603/kp.2013.0261.

    Article  PubMed  Google Scholar 

  6. Fletcher GF, Ades PA, Kligfield P, Arena R, Balady GJ, Bittner VA, et al. Exercise standards for testing and training: a scientific statement from the American Heart Association. Circulation. 2013;128(8):873–934. doi:10.1161/CIR.0b013e31829b5b44.

    Article  PubMed  Google Scholar 

  7. Piepoli MF, Corra U, Benzer W, Bjarnason-Wehrens B, Dendale P, Gaita D, et al. Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil Off J Eur Soc Cardiol, Work Groups Epidemiol & Prev Cardiac Rehabili Exerc Physiol. 2010;17(1):1–17. doi:10.1097/HJR.0b013e3283313592.

    Google Scholar 

  8. Crisafulli A, Pagliaro P. Effects of physical exercise on cardiovascular diseases: biochemical, cellular, and organ effects. 2015;2015:853632. doi:10.1155/2015/853632.

  9. Valeur N, Clemmensen P, Saunamaki K, Grande P. The prognostic value of pre-discharge exercise testing after myocardial infarction treated with either primary PCI or fibrinolysis: a DANAMI-2 sub-study. Eur Heart J. 2005;26(2):119–27. doi:10.1093/eurheartj/ehi057.

    Article  PubMed  Google Scholar 

  10. Dorn J, Naughton J, Imamura D, Trevisan M. Prognostic value of peak exercise systolic blood pressure on long-term survival after myocardial infarction. Am J Cardiol. 2001;87(2):213–6. a8

    Article  CAS  PubMed  Google Scholar 

  11. Naughton J, Dorn J, Oberman A, Gorman PA, Cleary P. Maximal exercise systolic pressure, exercise training, and mortality in myocardial infarction patients. Am J Cardiol. 2000;85(4):416–20.

    Article  CAS  PubMed  Google Scholar 

  12. Yu CM, Li LS, Lam MF, Siu DC, Miu RK, Lau CP. Effect of a cardiac rehabilitation program on left ventricular diastolic function and its relationship to exercise capacity in patients with coronary heart disease: experience from a randomized, controlled study. Am Heart J. 2004;147(5):e24. doi:10.1016/j.ahj.2003.12.004.

    Article  PubMed  Google Scholar 

  13. Milani RV, Lavie CJ, Cassidy MM. Effects of cardiac rehabilitation and exercise training programs on depression in patients after major coronary events. Am Heart J. 1996;132(4):726–32.

    Article  CAS  PubMed  Google Scholar 

  14. Lavie CJ, Milani RV. Effects of cardiac rehabilitation programs on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in a large elderly cohort. Am J Cardiol. 1995;76(3):177–9.

    Article  CAS  PubMed  Google Scholar 

  15. Staniute M, Brozaitiene J, Burkauskas J, Kazukauskiene N, Mickuviene N, Bunevicius R. Type D personality, mental distress, social support and health-related quality of life in coronary artery disease patients with heart failure: a longitudinal observational study. Health Qual Life Outcomes. 2015;13:1. doi:10.1186/s12955-014-0204-2.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Burkauskas J, Brozaitiene J, Bunevicius A, Neverauskas J, Zaliunaite V, Bunevicius R. Association of depression, anxiety, and type D personality with cognitive function in patients with coronary artery disease. Cogn Behav Neurol Off J Soc Behav Cogn Neurol. 2016;29(2):91–9. doi:10.1097/wnn.0000000000000093.

  17. Howarter AD, Bennett KK, Barber CE, Gessner SN, Clark JM. Exercise self-efficacy and symptoms of depression after cardiac rehabilitation: predicting changes over time using a piecewise growth curve analysis. J Cardiovasc Nurs. 2014;29(2):168–77. doi:10.1097/JCN.0b013e318282c8d6.

  18. Milani RV, Lavie CJ, Mehra MR, Ventura HO. Impact of exercise training and depression on survival in heart failure due to coronary heart disease. Am J Cardiol. 2011;107(1):64–8. doi:10.1016/j.amjcard.2010.08.047.

    Article  PubMed  Google Scholar 

  19. Lavie CJ, Menezes AR, De Schutter A, Milani RV, Blumenthal JA. Impact of cardiac rehabilitation and exercise training on psychological risk factors and subsequent prognosis in patients with cardiovascular disease. Can J Cardiol. 2016;32(10s2):S365-s73. doi:10.1016/j.cjca.2016.07.508.

  20. Egger E, Schmid JP, Schmid RW, Saner H, von Kanel R. Depression and anxiety symptoms affect change in exercise capacity during cardiac rehabilitation. Eur J Cardiovasc Prev Rehabil. 2008;15(6):704–8. doi:10.1097/HJR.0b013e32830eb6c5.

    Article  PubMed  Google Scholar 

  21. Shen BJ, Gau JT. Influence of depression and hostility on exercise tolerance and improvement in patients with coronary heart disease. Int J Behav Med. 2016; doi:10.1007/s12529-016-9598-z.

  22. De Schutter A, Lavie CJ, Milani RV. Relative importance of comorbid psychological symptoms in patients with depressive symptoms following phase II cardiac rehabilitation. Postgrad Med. 2011;123(6):72–8. doi:10.3810/pgm.2011.11.2497.

    Article  PubMed  Google Scholar 

  23. Lavoie KL, Fleet RP, Lesperance F, Arsenault A, Laurin C, Frasure-Smith N, et al. Are exercise stress tests appropriate for assessing myocardial ischemia in patients with major depressive disorder? Am Heart J. 2004;148(4):621–7. doi:10.1016/j.ahj.2004.04.009.

    Article  PubMed  Google Scholar 

  24. Korzeniowska-Kubacka I, Bilińska M, Piotrowska D, Stepnowska M, Piotrowicz R. The impact of exercise-only-based rehabilitation on depression and anxiety in patients after myocardial infarction. Eur J Cardiovasc Nurs.0(0):1474515116682123. doi:10.1177/1474515116682123.

  25. Bunevicius A, Stankus A, Brozaitiene J, Girdler SS, Bunevicius R. Relationship of fatigue and exercise capacity with emotional and physical state in patients with coronary artery disease admitted for rehabilitation program. Am Heart J. 2011;162(2):310–6. doi:10.1016/j.ahj.2011.05.003.

    Article  PubMed  Google Scholar 

  26. Pelle AJ, Denollet J, Zwisler A-D, Pedersen SS. Overlap and distinctiveness of psychological risk factors in patients with ischemic heart disease and chronic heart failure: are we there yet? J Affect Disord. 2009;113(1):150–6.

    Article  PubMed  Google Scholar 

  27. Beck AT, Steer RA, Brown GK. Beck depression inventory-II. San Antonio, TX. 1996:78204–2498.

  28. Denollet J, Pedersen SS, Daemen J, de Jaegere P, Serruys PW, van Domburg RT. Reduced positive affect (anhedonia) predicts major clinical events following implantation of coronary-artery stents. J Intern Med. 2008;263(2):203–11. doi:10.1111/j.1365-2796.2007.01870.x.

    Article  CAS  PubMed  Google Scholar 

  29. Spielberger CDGR, Lushene R, Vagg PR, Jacobs GA. Manual for the state-trait anxiety inventory. Palo Alto, AC: Consulting Psychologist Press; 1983.

    Google Scholar 

  30. O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Jr., Chung MK, de Lemos JA et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the American College of Emergency Physicians and Society for Cardiovascular Angiography and Interventions. Catheter Cardiovasc Interv. 2013;82(1):E1–27. doi:10.1002/ccd.24776.

  31. Gibbons RJ, Balady GJ, Bricker JT, Chaitman BR, Fletcher GF, Froelicher VF, et al. ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (committee to update the 1997 exercise testing guidelines). J Am Coll Cardiol. 2002;40(8):1531–40.

    Article  PubMed  Google Scholar 

  32. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982;14(5):377–81.

    Article  CAS  PubMed  Google Scholar 

  33. Beck AT, Steer RA, Ball R, Ranieri W. Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996;67(3):588–97. doi:10.1207/s15327752jpa6703_13.

    Article  CAS  PubMed  Google Scholar 

  34. Vanheule S, Desmet M, Groenvynck H, Rosseel Y, Fontaine J. The factor structure of the Beck Depression Inventory-II: an evaluation. Assessment. 2008;15(2):177–87. doi:10.1177/1073191107311261.

    Article  PubMed  Google Scholar 

  35. Buckley TC, Parker JD, Heggie J. A psychometric evaluation of the BDI-II in treatment-seeking substance abusers. J Subst Abus Treat. 2001;20(3):197–204.

    Article  CAS  Google Scholar 

  36. Bunevicius A, Staniute M, Brozaitiene J, Bunevicius R. Diagnostic accuracy of self-rating scales for screening of depression in coronary artery disease patients. J Psychosom Res. 2012;72(1):22–5. doi:10.1016/j.jpsychores.2011.10.006.

    Article  PubMed  Google Scholar 

  37. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.

    Article  CAS  PubMed  Google Scholar 

  38. Bunevicius A, Peceliuniene J, Mickuviene N, Valius L, Bunevicius R. Screening for depression and anxiety disorders in primary care patients. Depress Anxiety. 2007;24(7):455–60. doi:10.1002/da.20274.

  39. Bunevicius A, Brozaitiene J, Stankus A, Bunevicius R. Specific fatigue-related items in self-rating depression scales do not bias an association between depression and fatigue in patients with coronary artery disease. Gen Hosp Psychiatry. 2011;33(5):527–9. doi:10.1016/j.genhosppsych.2011.06.009.

    Article  PubMed  Google Scholar 

  40. Bunevicius R, Matulevicius V. Short-lasting behavioural effects of thyrotropin-releasing hormone in depressed women: results of placebo-controlled study. Psychoneuroendocrinology. 1993;18(5–6):445–9.

    Article  CAS  PubMed  Google Scholar 

  41. Buneviciute J, Staniute M, Brozaitiene J, Girdler SS, Bunevicius R. Mood symptoms and personality dimensions as determinants of health-related quality of life in patients with coronary artery disease. J Health Psychol. 2013;18(11):1493–504. doi:10.1177/1359105312465909.

    Article  PubMed  Google Scholar 

  42. Mezzani A, Hamm LF, Jones AM, McBride PE, Moholdt T, Stone JA, et al. Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation. Eur J Prev Cardiol. 2013;20(3):442–67. doi:10.1177/2047487312460484.

    Article  PubMed  Google Scholar 

  43. Milani RV, Lavie CJ. Reducing psychosocial stress: a novel mechanism of improving survival from exercise training. Am J Med. 2009;122(10):931–8. doi:10.1016/j.amjmed.2009.03.028.

    Article  PubMed  Google Scholar 

  44. Ernstsen L, Rangul V, Nauman J, Nes BM, Dalen H, Krokstad S et al. Protective effect of regular physical activity on depression after myocardial infarction: The HUNT Study. Am J Med. 2016;129(1):82–8.e1. doi:10.1016/j.amjmed.2015.08.012.

  45. Bunevicius A, Brozaitiene J, Staniute M, Gelziniene V, Duoneliene I, Pop VJ, et al. Decreased physical effort, fatigue, and mental distress in patients with coronary artery disease: importance of personality-related differences. Int J Behav Med. 2014;21(2):240–7. doi:10.1007/s12529-013-9299-9.

  46. Kachur S, Menezes AR, De Schutter A, Milani RV, Lavie CJ. Significance of comorbid psychological stress and depression on outcomes after cardiac rehabilitation. Am J Med. 2016;129(12):1316–21. doi:10.1016/j.amjmed.2016.07.006.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Julius Burkauskas.

Ethics declarations

Funding

No funding was received.

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in our study involving human participants were in accordance with the ethical standards of the Ethics Committee for Biomedical Research at Lithuanian University of Health Sciences, Kaunas, Lithuania and conforming with the principles outlined in the Declaration of Helsinki.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kazukauskiene, N., Burkauskas, J., Macijauskiene, J. et al. Mental Distress Factors and Exercise Capacity in Patients with Coronary Artery Disease Attending Cardiac Rehabilitation Program. Int.J. Behav. Med. 25, 38–48 (2018). https://doi.org/10.1007/s12529-017-9675-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12529-017-9675-y

Keywords

Navigation