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Lifestyle Changes in Women at Genetic Risk of Breast Cancer: an Observational Study

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Abstract

Background

Lifestyle influences breast cancer risk. Women at increased familial risk may benefit from modifying behaviour, but it is not known to what extent they do so.

Purpose

This study aims to measure changes that UK (Scottish) women make in response to increased familial risk of breast cancer and attitudes to a risk-reduction trial.

Methods

A questionnaire, completed by 140 “breast cancer family” clinic patients, generated data on habitual diet, alcohol consumption and exercise, changes made after learning of breast cancer risk and attitudes to possible further changes. Subgroups of patients were defined by criteria likely to influence changes in behaviour. Between-group differences were analysed by Fisher's exact test and overall correlations by linear regression.

Results

Thirty-six subjects (26 %) reported no behavioural change but, overall, around 25 % of diet, exercise and alcohol items had been changed. Women perceiving their lifetime cancer risk to be high (>50 %) and those who were obese (BMI >25) had made significantly more changes than others. Younger women (<40 years) and those with daughters had made fewer changes. Almost all suggested elements of a risk-reduction trial were strongly supported.

Conclusions

Scottish women at increased risk of breast cancer have scope for protective changes in lifestyle and support a risk-reduction trial. The needs of younger women and of those with daughters should be addressed in its design.

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Acknowledgments

The authors are grateful to all the patients who contributed to this study, which was funded by the Leverhulme Trust.

Conflict of interest

The authors have no conflict of interest to disclose.

Author information

Authors and Affiliations

  1. Department of Clinical Genetics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK

    Lorna McLeish, David R. Goudie & Jonathan N. Berg

  2. Tayside Familial Breast/Ovarian Cancer Service, Ninewells Hospital, Dundee, DD1 9SY, UK

    Lorna McLeish, Marta M. Reis, Clare Stewart, David R. Goudie, Jonathan N. Berg, Kirstie A. Hanning, Helen Vysny & C. Michael Steel

  3. Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK

    Marta M. Reis & Clare Stewart

  4. Nightingale and Genesis Prevention Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK

    Michelle Harvie

  5. Medical School, University of St Andrews North Haugh, St Andrews, KY16 9TF, UK

    Kirstie A. Hanning & C. Michael Steel

Authors
  1. Lorna McLeish
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  2. Marta M. Reis
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  3. Clare Stewart
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  9. C. Michael Steel
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Corresponding author

Correspondence to C. Michael Steel.

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McLeish, L., Reis, M.M., Stewart, C. et al. Lifestyle Changes in Women at Genetic Risk of Breast Cancer: an Observational Study. Int.J. Behav. Med. 20, 514–521 (2013). https://doi.org/10.1007/s12529-012-9263-0

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  • DOI: https://doi.org/10.1007/s12529-012-9263-0

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