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The role of antiphospholipid antibodies (aPls) in infertile women: the long-lasting experience

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Reproductive Medicine and Biology

Abstract

Antiphospholipid antibodies (aPls) are generally characterized as heterogeneous and non-specific autoantibodies directed against various phospholipids such as cardiolipin, ph-serine, ph-inositol, ph-acid, ph-glycerol, ph-sphyngomyelin, ph-choline, annexins, and co-factor β2-glycoprotein I. aPls occur not only during autoimmune diseases but also during infectious diseases, essential hypertension, neurological complication, metabolic diseases, some drug abuse, and transplant loss. aPls are very often found in connection with reproductive failure such as repeated pregnancy loss and/or missed abortion, intrauterine fetal death, in preeclampsia, and repeated delivery of hypothrophic fetus. The presence of aPls, thrombosis, and fertility failure create primary or secondary antiphospholipid syndrome. This article explains some aspects and clinical and laboratory significance of the aPls in female infertility.

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Conflict of interest

Z. Ulcova-Gallova declares that she has no conflict of interest.

Human rights statements and informed consent

Informed consent was obtained from all patients included in all of our cited studies in this article.

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This article does not contain any studies with animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Genetics-Pilsen, Charles University, Pilsen, Czech Republic

    Zdenka Ulcova-Gallova

  2. Department of Gynecology and Obstetrics, Charles University, Pilsen, Czech Republic

    Zdenka Ulcova-Gallova

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  1. Zdenka Ulcova-Gallova
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Correspondence to Zdenka Ulcova-Gallova.

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Ulcova-Gallova, Z. The role of antiphospholipid antibodies (aPls) in infertile women: the long-lasting experience. Reprod Med Biol 14, 49–55 (2015). https://doi.org/10.1007/s12522-014-0196-y

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  • DOI: https://doi.org/10.1007/s12522-014-0196-y

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