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Singleton pregnancy outcomes after assisted and non-assisted reproductive technology in infertile patients

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Reproductive Medicine and Biology

Abstract

Purpose

Singleton pregnancy after assisted reproductive technology (ART) has been associated with higher risks of adverse pregnancy outcome than naturally conceived singleton pregnancy. This study was to elucidate whether the ART procedure is responsible for abnormal pregnancy outcome comparing those after ART and non-ART in infertile patients.

Methods

We compare the singleton pregnancy outcome of infertile patients in our university hospital between 2000 and 2008 following ART (351 pregnancies) and non-ART (213 pregnancies) procedures. Pregnancy outcome parameters were incidence of pregnancy induced hypertension, placenta previa, placental abruption, cesarean delivery, preterm birth, very preterm birth, stillbirth, low birth weight and very low birth weight.

Results

Most of the pregnancy outcome parameters were not significantly different between the ART group and the non-ART group. Only placenta previa was significantly higher in the ART group than in the non-ART group (odds ratio 4.0; 95 % CI 1.2–13.7).

Conclusions

ART procedure may itself be a risk factor for the development of placenta previa. Some of the abnormal perinatal outcomes that had been previously attributed to ART, however, may be due to the baseline characteristics of infertile patients.

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References

  1. Japan Society of Obstetrics and Gynecology [Internet] Available from http://www.jsog.or.jp/. Accessed 8 Mar 2012.

  2. Henningsen AK, Pinborg A, Lidegaard Ø, Vestergaard C, Forman JL, Andersen AN. Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling-cohort study. Fertil Steril. 2011;95:959–963.

    Google Scholar 

  3. Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol. 2004;103:551–63.

    Article  PubMed  Google Scholar 

  4. Schieve LA, Meikle SF, Ferre C, Peterson HB, Jeng G, Wilcox LS. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med. 2002;346:731–7.

    Article  PubMed  Google Scholar 

  5. Schieve LA, Ferre C, Peterson HB, Macaluso M, Reynolds MA, Wright VC. Perinatal outcome among singleton infants conceived through assisted reproductive technology in the United States. Obstet Gynecol. 2004;103:1144–53.

    Article  PubMed  Google Scholar 

  6. Wisborg K, Ingerslev HJ, Henriksen TB. In vitro fertilization and preterm delivery, low birth weight, and admission to the neonatal intensive care unit: a prospective follow-up study. Fertil Steril. 2010;94:2102–6.

    Article  PubMed  Google Scholar 

  7. Wang JX, Norman RJ, Kristiansson P. The effect of various infertility treatments on the risk of preterm birth. Hum Reprod. 2002;17:945–9.

    Article  PubMed  CAS  Google Scholar 

  8. Lambert RD. Safety issues in assisted reproductive technology: aetiology of health problems in singleton ART babies. Hum Reprod. 2003;18:1987–91.

    Article  PubMed  Google Scholar 

  9. Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstrap LC, Rouse DJ, et al. Williams Obstetrics. 23rd ed. New York: McGraw Hill; 2009.

    Google Scholar 

  10. Daskalakis G, Simou M, Zacharakis D, Detorakis S, Akrivos N, Papantoniou N, et al. Impact of placenta previa on obstetric outcome. Int J Gynaecol Obstet. 2011;114:238–41.

    Article  PubMed  Google Scholar 

  11. Bahar A, Abusham A, Eskandar M, Sobande A, Alsunaidi M. Risk factors and pregnancy outcome in different types of placenta previa. J Obstet Gynaecol Can. 2009;31:126–31.

    PubMed  Google Scholar 

  12. Fujimoto A, Fujiwara T, Oishi H, Hirata T, Yano T, Taketani Y. Predictive factors of successful pregnancy after assisted reproductive technology in women aged 40 years and older. Reprod Med Biol. 2009;8:145–9.

    Article  Google Scholar 

  13. Taketani Y, Kelly E, Yoshimura Y, Hoshiai H, Irahara M, Mizunuma H, et al. Recombinant follicle-stimulating hormone (follitropin alfa) versus purified urinary follicle-stimulating hormone in a low-dose step-up regimen to induce ovulation in Japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility: results of a single-blind Phase III study Reprod. Med Biol. 2010;9:99–106.

    CAS  Google Scholar 

  14. Isono W, Wada-Hiraike O, Shirane A, Fujimoto A, Osuga Y, Yano T, et al. Alternative strategies to in vitro fertilization/intracytoplasmic sperm injection treatment for aged infertile women. Reprod Med Biol. 2011;11:69–72.

    Article  Google Scholar 

  15. Oyelese Y, Smulian JC. Placenta previa, placenta accreta, and vasa previa. Obstet Gynecol. 2006;107:927–41.

    Article  PubMed  Google Scholar 

  16. Rosenberg T, Pariente G, Sergienko R, Wiznitzer A, Sheiner E. Critical analysis of risk factors and outcome of placenta previa. Arch Gynecol Obstet. 2011;284:47–51.

    Article  PubMed  Google Scholar 

  17. Ministry of Health Labour and Welfare Japan [Internet] Available from http://www.mhlw.go.jp/english/. Accessed 8 Mar 2012.

  18. De Sutter P, Veldeman L, Kok P, Szymczak N, Van der Elst J, Dhont M. Comparison of outcome of pregnancy after intra-uterine insemination (IUI) and IVF. Hum Reprod. 2005;20:1642–6.

    Article  PubMed  Google Scholar 

  19. Maternal and child health foundation association. Maternal and child health statistics of Japan 2010.

  20. Draper ES, Kurinczuk JJ, Abrams KR, Clarke M. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case-control analysis. Lancet. 1999;353:1746–9.

    Article  PubMed  CAS  Google Scholar 

  21. Ananth CV, Smulian JC, Vintzileos AM. The association of placenta previa with history of cesarean delivery and abortion: A meta-analysis. Am J Obstet Gynecol. 1997;177:1071–8.

    Article  PubMed  CAS  Google Scholar 

  22. Oya A, Nakai A, Miyake H, Kawabata I, Takeshita T. Risk factors for peripartum blood transfusion in women with placenta previa: a retrospective analysis. J Nippon Med Sch. 2008;75:146–51.

    Article  Google Scholar 

  23. Romundstad LB, Romundstad PR, Sunde A, von Düring V, Skjaerven R, Vatten LJ. Increased risk of placenta previa in pregnancies following IVF/ICSI; a comparison of ART and non-ART pregnancies in the same mother. Hum Reprod. 2006;21:2353–8.

    Article  PubMed  Google Scholar 

  24. Farhi J, Ben-Haroush A, Andrawus N, Pinkas H, Sapir O, Fisch B, et al. High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation. Reprod BioMed Online. 2010;21:331–7.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ryo Tsutsumi, Akihisa Fujimoto, Yutaka Osuga, Nagisa Ooi, Yuri Takemura, Minako Koizumi, Tetsu Yano & Yuji Taketani

Authors
  1. Ryo Tsutsumi
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  2. Akihisa Fujimoto
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  3. Yutaka Osuga
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  4. Nagisa Ooi
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  5. Yuri Takemura
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  6. Minako Koizumi
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  7. Tetsu Yano
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  8. Yuji Taketani
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Correspondence to Akihisa Fujimoto.

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Tsutsumi, R., Fujimoto, A., Osuga, Y. et al. Singleton pregnancy outcomes after assisted and non-assisted reproductive technology in infertile patients. Reprod Med Biol 11, 149–153 (2012). https://doi.org/10.1007/s12522-012-0125-x

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  • DOI: https://doi.org/10.1007/s12522-012-0125-x

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