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Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial

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Abstract

Background

Jaundice is a common neonatal problem. This study was conducted to determine the effect of metoclopramide on neonatal bilirubin and maternal prolactin (primary outcomes) and milk volume (secondary outcome).

Methods

This triple-blind, randomized, controlled, clinical trial was conducted on 112 mothers. The participants were assigned to the intervention (metoclopramide) and control groups (placebo) using block randomization. Ten-mg metoclopramide and placebo tablets were taken by the participants three times a day. The intervention began in the first 2–10 hours after childbirth and continued until the fifth day. The mothers’ prolactin level was measured on the first morning after the intervention and on the sixth day (1 day after the intervention was over). Neonatal total bilirubin was also measured before the intervention and on the sixth day.

Results

After the intervention, the two groups did not differ significantly in terms of the mean neonatal indirect bilirubin (P = 0.565) and milk volume (P = 0.261), but the mean serum prolactin was significantly higher in the metoclopramide group compared to the placebo group (adjusted mean difference 37; 95% confidence interval 58.1–16.5; P = 0.001).

Conclusions

Metoclopramide increased maternal serum prolactin but had no effects on neonatal jaundice. The insufficient numbers of studies on this subject mandate further research.

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Acknowledgements

We wish to express our gratitude to Mr. Neginfar (Alzahra Laboratory Technician) and all the participants.

Funding

This study was funded by Tabriz University of Medical Sciences.

Author information

Authors and Affiliations

  1. Department of Midwifery, Students Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran

    Shirin Osouli Tabrizi & Robabe Seyedi

  2. Midwifery Department, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mojgan Mirghafourvand

  3. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Abdollah Jannat Dost

  4. Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran

    Sakineh Mohammad-Alizadeh-Charandabi

  5. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

    Yousef Javadzadeh

Authors
  1. Shirin Osouli Tabrizi
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  2. Mojgan Mirghafourvand
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  3. Abdollah Jannat Dost
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  4. Sakineh Mohammad-Alizadeh-Charandabi
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  5. Yousef Javadzadeh
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  6. Robabe Seyedi
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Contributions

SOT and RS contributed to the study design, data collection, data interpretation and writing of the manuscript. MM, AJD, and SM contributed to study design, data interpretation and revision of the manuscript. YJ contributed to study design, data interpretation and revision of the manuscript, and prepared drug and placebo. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Mojgan Mirghafourvand.

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Ethical approval

This study was approved by the Ethics Committee of the Research and Technology Deputy of Tabriz University of Medical Sciences (IR.TBZMED.REC.1395.1020). Written informed consent was obtained from all individual participants included in the study.

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

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Tabrizi, S.O., Mirghafourvand, M., Dost, A.J. et al. Effect of metoclopramide administration to mothers on neonatal bilirubin and maternal prolactin: a randomized, controlled, clinical trial. World J Pediatr 15, 135–142 (2019). https://doi.org/10.1007/s12519-018-0217-8

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  • DOI: https://doi.org/10.1007/s12519-018-0217-8

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