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CAIPIRINHA-accelerated T1w 3D-FLASH for small-bowel MR imaging in pediatric patients with Crohn’s disease: assessment of image quality and diagnostic performance

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Abstract

Background

The “Controlled Aliasing In Parallel Imaging Results In Higher Acceleration” (CAPIRINHA) technique greatly accelerates T1w 3D fast low angle shot (FLASH) scans while maintaining high image quality. We studied image quality and conspicuity of inflammatory lesions on CAIPIRINHA-accelerated imaging for pediatric small-bowel magnetic resonance imaging (MRI).

Methods

Forty-four consecutive patients (mean 14±3 years, 18 girls) underwent small-bowel MRI (MR enterography, MRE) at 1.5 T including diffusion-weighted imaging (DWI), contrast-enhanced CAIPIRINHA 3D-FLASH and standard 2D-FLASH imaging. Crohn’s disease (CD) was confirmed in 26 patients, 18 patients served as control. Independent blinded readings were performed for grading of image quality and conspicuity of CD lesions on CAIPIRINHA FLASH and standard FLASH images in comparison to a reference standard comprising imaging and endoscopic data.

Results

CAIPIRINHA FLASH yielded significantly higher image quality with good inter-observer agreement (κ=0.68) and showed better visual delineation in 40% of the assessed bowel lesions, as compared to standard FLASH. There was full agreement for identification of CD patients between CAIPIRINHA and standard FLASH. CAIPIRINHA FLASH detected two small-bowel lesions that were not seen on standard FLASH. DWI revealed additional inflammatory lesions inconspicuous on contrast-enhanced imaging. MRE showed an overall diagnostic accuracy of 93%.

Conclusion

We present first evidence that CAIPIRINHA greatly accelerates T1w imaging in paediatric MRE without trade-off in image quality or lesion conspicuity and is thus preferable to standard FLASH imaging.

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Authors and Affiliations

  1. Department of Radiation Oncology, University Hospital Wuerzburg, 97080, Wuerzburg, Germany

    Mengxia Li, Thomas Pabst, Thorsten Bley, Herbert Köstler & Henning Neubauer

  2. Department of Pediatrics, University Hospital Wuerzburg, 97080, Wuerzburg, Germany

    Anke Dick

  3. Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Oberduerrbacher Str. 6, 97080, Wuerzburg, Germany

    Nicole Hassold

Authors
  1. Mengxia Li
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  2. Anke Dick
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  3. Nicole Hassold
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  4. Thomas Pabst
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  5. Thorsten Bley
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  6. Herbert Köstler
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  7. Henning Neubauer
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Correspondence to Nicole Hassold.

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Li, M., Dick, A., Hassold, N. et al. CAIPIRINHA-accelerated T1w 3D-FLASH for small-bowel MR imaging in pediatric patients with Crohn’s disease: assessment of image quality and diagnostic performance. World J Pediatr 12, 455–462 (2016). https://doi.org/10.1007/s12519-016-0047-5

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  • DOI: https://doi.org/10.1007/s12519-016-0047-5

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