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Effects of potato-derived protease inhibitors on perianal dermatitis after colon resection for long-segment Hirschsprung’s disease



After resection of long-segment Hirschsprung’s disease, severe perianal dermatitis (SPAD) may occur because of high stool frequency and elevated concentrations of fecal pancreatic proteases. We investigated prospectively the effect of potato-derived protease inhibitors (PPI) on skin conditions in children with postoperative SPAD.


Four children (aged 12 to 24 months) with therapy-resistant SPAD after transanal endorectal pull-through for long-segment Hirschsprung’s disease received topical PPI (1% in 20% zinc ointment) with each diaper-change. Parents noted down a subjective dermatitis score daily. Photo documentation and outpatient visits were made to assess the treatment results.


No adverse effects were observed after treatment with PPI. A remarkable improvement of the dermatitis in 3 of the 4 patients as well as improvements in pain and sleep disorders were observed during the PPI-treatment course.


The results of the study suggest that PPI may reduce otherwise intractable protease-induced skin irritation in infants.

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Correspondence to Steffen Berger.

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Berger, S., Rufener, J., Klimek, P. et al. Effects of potato-derived protease inhibitors on perianal dermatitis after colon resection for long-segment Hirschsprung’s disease. World J Pediatr 8, 173–176 (2012).

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Key words

  • Hirschsprung’s disease
  • perianal dermatitis
  • protease inhibitor
  • transanal endorectal pull-through