World Journal of Pediatrics

, Volume 5, Issue 2, pp 122–126 | Cite as

Pediatric reference intervals for soluble transferrin receptor and transferrin receptor-ferritin index

  • Cara Lianne Ooi
  • Nathalie Lepage
  • Ed Nieuwenhuys
  • Ajay Parkash Sharma
  • Guido Filler
Original Article



Recent studies showing an improved diagnosis of iron deficiency (ID) with soluble transferrin receptor (sTfR) and sTfR-ferritin index did not take into account the age-dependency of sTfR and ferritin. Moreover, there is a paucity of data on pediatric reference intervals for sTfR and sTfR-ferritin index.


A study cohort of 436 apparently healthy children was analyzed to establish reference intervals for ferritin, transferrin, sTfR and sTfR-ferritin index. To account for age-dependency, standard deviation scores (Z-scores) for these markers were calculated. The association between these parameters and C-reactive protein (CRP) was analyzed.


The Z-scores of ferritin, transferrin and sTfR had a significant association with CRP, whereas the Z-score of sTfR-ferritin did not correlate with CRP. The reference intervals of these parameters were reported.


Among the different markers of ID, the Z-scores of sTfR, transferrin and ferritin, but not sTfR-ferritin index, associate with the inflammatory status.

Key words

C-reactive protein ferritin reference interval soluble transferrin receptor soluble transferrin receptor-ferritin index transferrin 


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine and Springer-Verlag GmbH 2009

Authors and Affiliations

  • Cara Lianne Ooi
    • 1
  • Nathalie Lepage
    • 2
  • Ed Nieuwenhuys
    • 3
  • Ajay Parkash Sharma
    • 1
  • Guido Filler
    • 1
  1. 1.Department of Pediatrics, Children’s Hospital, London Health Science Centre, Schulich School of Medicine & DentistryUniversity of Western OntarioLondonCanada
  2. 2.Department of Pathology and Laboratory MedicineChildren’s Hospital of Eastern OntarioOttawaCanada
  3. 3.Sanquin Diagnostic ServicesAmsterdamThe Netherlands

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