De impact van hubdisfunctioneren op cognitie

Samenvatting

De hersenen worden steeds vaker benaderd vanuit netwerkperspectief, waarbij de verbindingen tussen functionele hersengebieden en hun karakteristieke patronen in kaart gebracht worden. Belangrijke kenmerken van het hersennetwerk zijn optimale integratie en segregatie (het zogeheten small-worldprincipe). Daarnaast bevat het hersennetwerk een aantal gebieden die een centrale rol innemen in het netwerk, de zogenaamde hubs. Disfunctioneren van deze hubs is in verband gebracht met veel neurologische aandoeningen. Op basis van de resultaten van twee recente studies wordt het effect gedemonstreerd van een hersenbeschadiging op het falen van hersennetwerken door overbelasting van hubs (hub-overload). We beschrijven hoe de mate van hub-overload samenhangt met cognitief functioneren en zelfs postoperatieve veranderingen kan voorspellen.

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Correspondence to Jolanda Derks.

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Derks, J., Douw, L. De impact van hubdisfunctioneren op cognitie. Neuropraxis 21, 121–126 (2017). https://doi.org/10.1007/s12474-017-0164-5

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Trefwoorden

  • hersennetwerken
  • hubs
  • hub-overload
  • dynamisch hersennetwerk
  • hersentumor