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In-vitrofertilisatie, ouderlijke subfertiliteit en de gezondheid en ontwikkeling van het nageslacht

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Neuropraxis

Samenvatting

Ruim één op de tien paren kampt met subfertiliteit: hen lukt het niet om binnen een jaar zwanger te worden. Een toenemend aantal paren maakt gebruik van vruchtbaarheidsbehandelingen, zoals in-vitrofertilisatie (IVF). De gezondheid en ontwikkeling van IVF-kinderen is daarom van maatschappelijk belang. In dit artikel vatten we de literatuur over dit onderwerp samen. We maken hierbij ook gebruik van de gegevens van de Groningen ART (assisted reproductive technology) cohortstudie, een prospectieve, longitudinale follow-upstudie die de gezondheid en ontwikkeling van eenlingen van subfertiele paren, die al dan niet IVF ondergingen, in kaart brengt. Tot op heden werd de ontwikkeling van deze kinderen tot en met de leeftijd van vier jaar onderzocht. De belangrijkste conclusie is dat niet zozeer IVF-behandelingen, maar juist de onderliggende subfertiliteit van de ouders geassocieerd is met aangeboren afwijkingen en een minder optimale ontwikkeling van het zenuwstelsel. Een langere ‘tijd tot zwangerschap’ (TTZ), een maat voor de ernst van subfertiliteit, is hierbij bepalend. De resultaten benadrukken het belang van langdurige follow-up van kinderen van subfertiele ouders, die met of zonder IVF zwanger werden. Dit is vooral belangrijk in de huidige maatschappij waar de maternale leeftijd ten tijde van de conceptie, subfertiliteit en het toepassen van vruchtbaarheidsbehandelingen toenemen.

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Literatuur

  1. Ferraretti AP, Goossens V, Kupka M, Bhattacharya S, Mouzon J de, Castilla JA, et al. Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Hum Reprod. 2013;28:2318–31.

    Article  CAS  PubMed  Google Scholar 

  2. Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol. 2005;20:345–52.

    Article  CAS  PubMed  Google Scholar 

  3. Barker DJ. The origins of the developmental origins theory. J Intern Med. 2007;261:412–7.

    Article  CAS  PubMed  Google Scholar 

  4. Palermo G, Joris H, Devroey P, Steirteghem AC Van. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340:17–8.

    Article  CAS  PubMed  Google Scholar 

  5. Rongieres-Bertrand C, Olivennes F, Righini C, Fanchin R, Taieb J, Hamamah S, et al. Revival of the natural cycles in in-vitro fertilization with the use of a new gonadotrophin-releasing hormone antagonist (Cetrorelix): a pilot study with minimal stimulation. Hum Reprod. 1999;14:683–8.

    Article  CAS  PubMed  Google Scholar 

  6. Pelinck MJ, Vogel NE, Hoek A, Arts EG, Simons AH, Heineman MJ. Minimal stimulation IVF with late follicular phase administration of the GnRH antagonist cetrorelix and concomitant substitution with recombinant FSH: a pilot study. Hum Reprod. 2005;20:642–8.

    Article  CAS  PubMed  Google Scholar 

  7. Rackow BW, Kliman HJ, Taylor HS. GnRH antagonists may affect endometrial receptivity. Fertil Steril. 2008;89:1234–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Dumoulin JC, Land JA, Montfoort AP van, Nelissen EC, Coonen E, Derhaag JG, et al. Effect of in vitro culture of human embryos on birthweight of newborns. Hum Reprod. 2010;25:605–12.

    Article  PubMed  Google Scholar 

  9. Draper ES, Kurinczuk JJ, Abrams KR, Clarke M. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case-control analysis. Lancet. 1999;353:1746–9.

    Article  CAS  PubMed  Google Scholar 

  10. Salem Yaniv S, Levy A, Wiznitzer A, Holcberg G, Mazor M, Sheiner E. A significant linear association exists between advanced maternal age and adverse perinatal outcome. Arch Gynecol Obstet. 2011;283:755–9.

    Article  PubMed  Google Scholar 

  11. Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ. 2004;328(7434):261.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Romundstad LB, Romundstad PR, Sunde A, During V von, Skjaerven R, Gunnell D, et al. Effects of technology or maternal factors on perinatal outcome after assisted fertilisation: a population-based cohort study. Lancet. 2008;372:737–43.

    Article  PubMed  Google Scholar 

  13. Henningsen AK, Pinborg A, Lidegaard O, Vestergaard C, Forman JL, Andersen AN. Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling-cohort study. Fertil Steril. 2011;95:959–63.

    Article  PubMed  Google Scholar 

  14. Basso O, Baird DD. Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort. Hum Reprod. 2003;18:2478–84.

    Article  PubMed  Google Scholar 

  15. Raatikainen K, Kuivasaari-Pirinen P, Hippelainen M, Heinonen S. Comparison of the pregnancy outcomes of subfertile women after infertility treatment and in naturally conceived pregnancies. Hum Reprod. 2012;27:1162–9.

    Article  PubMed  Google Scholar 

  16. Middelburg KJ, Heineman MJ, Bos AF, Pereboom M, Fidler V, Hadders-Algra M. The Groningen ART cohort study: ovarian hyperstimulation and the in vitro procedure do not affect neurological outcome in infancy. Hum Reprod. 2009;24:3119–26.

    Article  CAS  PubMed  Google Scholar 

  17. Middelburg KJ, Haadsma ML, Heineman MJ, Bos AF, Hadders-Algra M. Ovarian hyperstimulation and the in vitro fertilization procedure do not influence early neuromotor development; a history of subfertility does. Fertil Steril. 2010;93:544–53.

    Article  PubMed  Google Scholar 

  18. Schendelaar P. Offspring of subfertile couples: neurodevelopmental outcome at preschool age. Groningen: Rijksuniversiteit Groningen; 2015.

    Google Scholar 

  19. Seggers J. Health of children born to subfertile couples – aetiological pathways and neurodevelopmental correlates. Groningen: Rijksuniversiteit Groningen; 2015.

    Google Scholar 

  20. Hansen M, Kurinczuk JJ, Milne E, Klerk N de, Bower C. Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2013;19:330–53.

    Article  PubMed  Google Scholar 

  21. Zhu JL, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ. 2006;333:679.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Seggers J, Haadsma ML, Bos AF, Heineman MJ, Keating P, Middelburg KJ, et al. Dysmorphic features in 2-year-old IVF/ICSI offspring. Early Hum Dev. 2012;88:823–9.

    Article  PubMed  Google Scholar 

  23. Ceelen M, Weissenbruch MM van, Vermeiden JP, Leeuwen FE van, Delemarre-van de Waal HA. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metab. 2008;93:1682–8.

    Article  CAS  PubMed  Google Scholar 

  24. Belva F, Roelants M, Schepper J De, Roseboom TJ, Bonduelle M, Devroey P, et al. Blood pressure in ICSI-conceived adolescents. Hum Reprod. 2012;27:3100–8.

    Article  CAS  PubMed  Google Scholar 

  25. Scherrer U, Rimoldi SF, Rexhaj E, Stuber T, Duplain H, Garcin S, et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation 2012;125:1890–6.

    Article  PubMed  Google Scholar 

  26. Middelburg KJ, Heineman MJ, Bos AF, Hadders-Algra M. Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI-a systematic review. Hum Reprod Update. 2008;14:219–31.

    Article  CAS  PubMed  Google Scholar 

  27. Graaf-Peters VB de, Hadders-Algra M. Ontogeny of the human central nervous system: what is happening when? Early Hum Dev. 2006;82:257–66.

    Article  PubMed  Google Scholar 

  28. Bay B, Mortensen EL, Kesmodel US. Assisted reproduction and child neurodevelopmental outcomes: a systematic review. Fertil Steril. 2013;100:844–53.

    Article  PubMed  Google Scholar 

  29. Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. Part II–Mental health and development outcomes. Hum Reprod Update. 2013;19:244–50.

    Article  CAS  PubMed  Google Scholar 

  30. Schendelaar P, Heuvel ER Van den, Heineman MJ, Bastide-Van Gemert S La, Middelburg KJ, Seggers J, et al. Increased time to pregnancy is associated with less optimal neurological condition in 4-year-old singletons, in vitro fertilization itself is not. Hum Reprod 2014;29:2773–86.

    Article  CAS  PubMed  Google Scholar 

  31. Hempel MS. The neurological examination for toddler-age. Groningen: University of Groningen; 1993.

    Google Scholar 

  32. Peters LH, Maathuis CG, Hadders-Algra M. Limited motor performance and minor neurological dysfunction at school age. Acta Paediatr 2011;100:271–8.

    Article  PubMed  Google Scholar 

  33. Jong M de, Punt M, Groot E De, Minderaa RB, Hadders-Algra M. Minor neurological dysfunction in children with autism spectrum disorder. Dev Med Child Neurol 2011;53:641–6.

    Article  PubMed  Google Scholar 

  34. Kaufman AS, Kaufman NL. Kaufman assessment battery for children, 2nd ed. Circle Pines: AGS Publishing; 2004.

    Google Scholar 

  35. Achenbach TM. Manual for the child behavior checklist 1 1/2-5 and 1991 profile. University of Vermont Department of Psychiatry. Burlington; 1991.

  36. Zhu JL, Basso O, Obel C, Hvidtjorn D, Olsen J. Infertility, infertility treatment and psychomotor development: the Danish National Birth Cohort. Paediatr Perinat Epidemiol 2009;23:98–106.

    Article  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Afdeling Kindergeneeskunde, Instituut voor Ontwikkelingsneurologie, Universitair Medisch Centrum Groningen, Groningen, Nederland

    Pamela Schendelaar, Jorien Seggers & Mijna Hadders-Algra

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  1. Pamela Schendelaar
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  2. Jorien Seggers
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  3. Mijna Hadders-Algra
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Correspondence to Pamela Schendelaar.

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Pamela Schendelaar en Jorien Seggers droegen in gelijke mate bij aan dit artikel.

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Schendelaar, P., Seggers, J. & Hadders-Algra, M. In-vitrofertilisatie, ouderlijke subfertiliteit en de gezondheid en ontwikkeling van het nageslacht. Neuroprax 19, 101–108 (2015). https://doi.org/10.1007/s12474-015-0090-3

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