Samenvatting
Met deep brain stimulation (DBS) wordt elektrische stimulatie van de hersenen bedoeld als therapie bij ernstige hersenziekten waarbij alle andere therapieën niet (meer) werken. DBS is volledig geaccepteerd bij de behandeling van de ziekte van Parkinson en ernstige essentiële tremoren. Deze techniek wordt de laatste jaren in toenemende mate onderzocht als therapie bij treatment-resistant depressie, obsessief-compulsieve stoornis, epilepsie en verslaving. In deze bijdrage wordt de achtergrond van deze techniek geschetst, waarbij de historische en moderne bijdragen van dieronderzoek een belangrijke rol spelen. Hoewel nog veel translationeel onderzoek nodig is, lijkt DBS een zeer waardevolle uitbreiding van de behandelmethoden voor ernstige neurologische en neuropsychiatrische ziekten.
Literatuur
Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science. 1990;249:1436–8.
Benabid AL, Pollak P, Gervason C, Hoffmann D, Gao M, Hommel M, et al. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet. 1991;337;403–6.
DeLong MR, Benabid AL. Discovery of high-frequency deep brain stimulation for treatment of Parkinson disease: 2014 Lasker Award. JAMA. 2014;312:1093–4.
Rousseaux MW, Zoghbi HY. Deep brain stimulation for Parkinson disease: The 2014 Lasker-DeBakey Clinical Medical Research Award. JAMA Neurol. 2015;72:259–60.
Wichmann T, DeLong MR. Deep brain stimulation for neurologic and neuropsychiatric disorders. Neuron. 2006;52(1):197–204.
Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45:651–60.
Gabriëls L, Cosyns P, Nuttin B, Demeulemeester H, Gybels J. Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: psychopathological and neuropsychological outcome in three cases. Acta Psychiatrica Scand. 2003;107:275–82.
Kuhn J, Gründler TO, Bauer R, Huff W, Fischer AG, Lenartz D, et al. Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring. Addict Biol. 2011;16:620–3.
Deisseroth K. Circuit dynamics of adaptive and maladaptive behaviour. Nature. 2014;505:309–17.
Yizhar O, Fenno LE, Davidson TJ, Mogri M, Deisseroth K. Optogenetics in neural systems. Neuron. 2011;71:9–34.
Steinberg EE, Christoffel DJ, Deisseroth K, Malenka RC. Illuminating circuitry relevant to psychiatric disorders with optogenetics. Cur Opin Neurobiol. 2015;30C:9–16.
Mayberg HS. Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci. 1997;9:471–81.
Anderson RJ, Frye MA, Abulseoud OA, Lee KH, McGillivray JA, Berk M, et al. Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action. Neurosci Biobehav Rev. 2012;36:1920–33.
Bernardis LL, Bellinger LL. The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev. 1996;20:189–287.
Valenstein ES. Brain control. A critical examination of brain stimulation and psychosurgery. New York: Wiley; 1973.
Olds J, Milner P. Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol. 1954;47:419–27.
Döbrössy MD, Furlanetti LL, Coenen VA. Electrical stimulation of the medial forebrain bundle in pre-clinical studies of psychiatric disorders. Neurosci Biobehav Rev. 2015;49C:32–42.
Gálvez JF, Keser Z, Mwangi B, Ghouse AA, Fenoy AJ, Schulz PE, et al. The medial forebrain bundle as a deep brain stimulation target for treatment resistant depression: a review of published data. Prog Neuropsychopharmacol Biol Psychiatry. 2014;58C:59–70.
Prins J, Kenny PJ, Doomernik I, Schreiber R, Olivier B, Korte SM. The triple reuptake inhibitor DOV 216,303 induces long-lasting enhancement of brain reward activity as measured by intracranial self-stimulation in rats. Eur J Pharmacol. 2012;693:51–6.
Delaloye S, Holtzheimer PE. Deep brain stimulation in the treatment of depression. Dialog Clin Neurosci. 2014;16:83–91.
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Olivier, B. Deep brain stimulation – nieuwe behandeling voor ernstige hersenziekten. Neuroprax 19, 65–69 (2015). https://doi.org/10.1007/s12474-015-0086-z
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DOI: https://doi.org/10.1007/s12474-015-0086-z