Microbloedingen zijn kleine ronde laesies (<10mm), zichtbaar als hypo-intense (zwarte) signalen op T2*-gewogen MRI-sequenties (Greenberg et al., 2009). Deze technieken zijn gevoelig voor lokale verstoring van het magnetische veld, bijvoorbeeld door ijzerhoudende materialen. De radiologische afwijkingen corresponderen met specifieke onderliggende pathologische afwijkingen, te weten ophopingen van het bloedafbraakproduct hemosiderine, langs de kleine hersenvaten (Greenberg et al., 2009; Fazekas et al., 1999).
Abstract
Microbleeds are small dot-like lesions appearing as hypo-intense signals in the brain parenchyma on gradient echo T2*-weighted magnetic resonance sequences. In Alzheimer’s disease, microbleeds are of special interest as they may contribute to the pathophysiology of the disease. Furthermore, they may affect the clinical course of the disease.
The aim of this article is to review available data to understand the occurrence and meaning of microbleeds. Furthermore, we aim to discuss the underlying pathology as well as the clinical associations of microbleeds in the context of Alzheimer’s disease.
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neuroloog, neuropsychologe
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Goos, J., van der Flier, W. Microbloedingen bij de ziekte van Alzheimer: de onschuld voorbij?. NEUROPRAXIS 15, 134–137 (2011). https://doi.org/10.1007/s12474-011-0025-6
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DOI: https://doi.org/10.1007/s12474-011-0025-6