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De rol van presynaptische dopaminerge beeldvorming bij de ziekte van Parkinson

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Neuropraxis

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De ziekte van Parkinson is een langzaam progressieve degeneratieve aandoening die gekenmerkt wordt door progressieve degeneratie van dopaminerge neuronen in de substantia nigra. De klassieke trias van klinische symptomen van de ziekte van Parkinson bestaat uit: bradykinesie, rigiditeit en rusttremor. In het begin van de ziekte kunnen deze symptomen nog subtiel zijn en kan het daarom lastig zijn om uitsluitend op basis daarvan de juiste diagnose te stellen.

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Literatuur

  • Antonini, A., Vontobel, P., Psylla, M., Gunther, I., Maguire, P.R., Missimer, J. & Leenders, K.L. (1995). Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson’s disease. Archives of Neurology, 52, 1183–1190.

    Article  PubMed  CAS  Google Scholar 

  • Asenbaum, S., Brucke, T., Pirker, W., Podreka, I., Angelberger, P., Wenger, S., Wober, C., Muller, C. & Deecke, L. (1997). Imaging of dopamine transporters with iodine-123-beta-CIT and spect in Parkinson’s disease. Journal of Nuclear Medicine, 38, 1–6.

    PubMed  CAS  Google Scholar 

  • Benamer, H.T., Patterson, J., Wyper, D.J., Hadley, D.M., Macphee, G.J. & Grosset, D.G. (2000a). Correlation of Parkinson’s disease severity and duration with 123I-fp-cit spect striatal uptake. Movement Disorders, 15, 692–698.

    Article  CAS  Google Scholar 

  • Benamer, T.S., Patterson, J., Grosset, D.G., Booij, J., Bruin, K. de, Royen, E. van, Speelman, J.D., Horstink, M.H., Sips, H.J., Dierckx, R.A., Versijpt, J., Decoo, D., Van Der, L.C., Hadley, D.M., Doder, M., Lees, A.J., Costa, D.C., Gacinovic, S., Oertel, W.H., Pogarell, O., Hoeffken, H., Joseph, K., Tatsch, K., Schwarz, J. & Ries, V. (2000b). Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-fp-cit spect imaging: the [123I]-fp-cit study group. Movement Disorders, 15, 503–510.

    Article  CAS  Google Scholar 

  • Booij, J., Bergmans P., Winogrodzka, A., Speelman, J.D. & Wolters, E.C. (2001). Imaging of dopamine transporters with [123I]fp-cit spect does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson’s disease. Synapse, 39, 101–108.

    Article  PubMed  CAS  Google Scholar 

  • Booij, J., Tissingh, G., Boer, G.J., Speelman, J.D., Stoof, J.C., Janssen, A.G., Wolters, E.C. & Royen, E.A van. (1997). [123I]fp-cit spect shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 62, 133–140.

    Article  CAS  Google Scholar 

  • Dhawan, V., Ma, Y.L., Pillai, V., Spetsieris, P., Chaly, T., Belakhlef, A., Margouleff, C. & Eidelberg, D. (2002). Comparative analysis of striatal FDOPA uptake in Parkinson’s disease: Ratio method versus graphical approach. Journal of Nuclear Medicine, 43, 1324–1330.

    PubMed  Google Scholar 

  • Eidelberg, D., Takikawa, S., Dhawan, V., Chaly, T., Robeson, W., Dahl, R., Margouleff, D., Moeller, J.R., Patlak, C.S. & Fahn, S. (1993). Striatal F-18 Dopa Uptake - Absence of An Aging Effect. Journal of Cerebral Blood Flow and Metabolism 13, 881–888.

    Article  PubMed  CAS  Google Scholar 

  • Eshuis, S.A., Jager, P.L., Maguire, R.P., Jonkman, S., Dierckx, R.A. & Leenders, K.L. (2009). Direct comparison of fp-cit spect and f-dopa pet in patients with Parkinson’s disease and healthy controls. European. Journal of Nuclear Medicine and Molecular Imaging, 36, 454–462.

    Article  PubMed  CAS  Google Scholar 

  • Eshuis, S.A., Maguire, R.P., Leenders, K.L., Jonkman, S. & Jager, P.L. (2006). Comparison of fp-cit spect with f-dopa pet in patients with de novo and advanced Parkinson’s disease. Euopean. Journal of Nuclear Medicine and Molecular Imaging, 33, 200–209.

    Article  CAS  Google Scholar 

  • Fearnley, J.M. & Lees, A.J. (1991). Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain, 114 (Pt 5), 2283–2301.

    Article  PubMed  Google Scholar 

  • Garnett, E.S., Nahmias, C. & Firnau, G. (1984). Central dopaminergic pathways in hemiparkinsonism examined by positron emission tomography. Canadian Journal of Neurological Science, 11, 174–179.

    CAS  Google Scholar 

  • Goodman, M.M., Keil, R., Shoup, T.M., Eshima, D., Eshima, L., Kilts, C., Votaw, J., Camp, V.M., Votaw, D., Smith, E., Kung, M.P., Malveaux, E., Watts, R., Huerkamp, M., Wu, D., Garcia, E. & Hoffman, J.M. (1997). Fluorine-18-FPct: a pet radiotracer for imaging dopamine transporters. Journal of Nuclear Medicine, 38, 119–126.

    PubMed  CAS  Google Scholar 

  • Haaxma, C.A., Borm, G.F., Bloem, B.R. & Horstink, M.W.I.M. (2006). Gender differences in Parkinson’s disease. Movement Disorders, 21, S84.

    Google Scholar 

  • Haycock, J.W., Becker, L., Ang, L., Furukawa, Y., Hornykiewicz, O. & Kish, S.J. (2003). Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. Journal of Neurochemistry, 87, 574–585.

    Article  PubMed  CAS  Google Scholar 

  • Hilker, R., Thomas, A.V., Klein, J.C., Weisenbach, S., Kalbe E., Burghaus, L., Jacobs, A.H., Herholz, K. & Heiss, W.D. (2005). Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways. Neurology, 65, 1716–1722.

    Article  PubMed  CAS  Google Scholar 

  • Hughes, A.J., Daniel, S.E., Ben Shlomo, Y. & Lees, A.J. (2002). The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain, 125, 861–870.

    Article  PubMed  Google Scholar 

  • Hughes, A.J., Daniel, S.E., Blankson, S. & Lees, A.J. (1993). A Clinicopathological Study of 100 Cases of Parkinson’s-Disease. Archives of Neurology, 50, 140–148.

    Article  PubMed  CAS  Google Scholar 

  • Ishikawa, T., Dhawan, V., Kazumata, K., Chaly, T., Mandel, F., Neumeyer, J., Margouleff, C., Babchyck, B., Zanzi, I. & Eidelberg, D. (1996). Comparative nigrostriatal dopaminergic imaging with iodine-123-beta cit/fpspect and fluorine-18-fdopa/pet. Journal of Nuclear Medicine, 37, 1760–1765.

    PubMed  CAS  Google Scholar 

  • Ito, Y., Fujita, M., Shimada, S., Watanabe, Y., Okada, T., Kusuoka, H., Tohyama, M. & Nishimura, T. (1999). Comparison between the decrease of dopamine transporter and that of l-dopa uptake for detection of early to advanced stage of Parkinson’s disease in animal models. Synapse, 31, 178–185.

    Article  PubMed  CAS  Google Scholar 

  • Kaasinen, V., Nurmi, E., Bruck, A., Bergman, J., Solin, O. & Rinne, J.O. (2001). Increased frontal [F-18]fluorodopa uptake in early Parkinson’s Disease: sex differences in the prefrontal cortex. Brain, 124, 1125–1130.

    Article  PubMed  CAS  Google Scholar 

  • Kazumata, K., Dhawan, V., Chaly, T., Antonini, A., Margouleff, C., Belakhlef, A., Neumeyer, J. & Eidelberg, D. (1998). Dopamine transporter imaging with fluorine-18-FPCIT and pet. Journal of Nuclear Medicine, 39, 1521–1530.

    PubMed  CAS  Google Scholar 

  • Kish, S.J., Zhong, X.H., Hornykiewicz, O. & Haycock, J.W. (1995). Striatal 3,4-dihydroxyphenylalanine decarboxylase in aging: disparity between postmortem and positron emission tomography studies? Annals of Neurology, 38, 260–264.

    Article  PubMed  CAS  Google Scholar 

  • Koerts, J., Leenders, K.L., Koning, M., Portman, A.T. & Beilen, M. van (2007). Striatal dopaminergic activity (fdopa-pet) associated with cognitive items of a depression scale (madrs) in Parkinson’s disease. European Journal of Neuroscience, 25, 3132–3136.

    Article  PubMed  Google Scholar 

  • Kuhl, D.E., Minoshima, S., Fessler, J.A., Frey, K.A., Foster, N.L., Ficaro, E.P., Wieland, D.M. & Koeppe, R.A. (1996). In vivo mapping of cholinergic terminals in normal aging, Alzheimers disease, and Parkinson’s disease. Annals of Neurology, 40, 399–410.

    Article  PubMed  CAS  Google Scholar 

  • Laakso, A., Vilkman, H., Bergman, J., Haaparanta, M., Solin, O., Syvalahti, E., Salokangas, R.K.R. & Hietala, J. (2002). Sex differences in striatal presynaptic dopamine synthesis capacity in healthy subjects. Biological Psychiatry, 52, 759–763.

    Article  PubMed  CAS  Google Scholar 

  • Lavalaye, J., Booij, J., Reneman, L., Habraken, J.B. & van Royen, E.A. (2000). Effect of age and gender on dopamine transporter imaging with [123I]FP- CIT Spet in healthy volunteers. Europan Journal of Nuclear Medicine, 27, 867–869.

    Article  CAS  Google Scholar 

  • Lee, C.S., Samii, A., Sossi, V., Ruth, T.J., Schulzer, M., Holden, J.E., Wudel, J., Pal, P.K., Fuente-Fernandez, R., Calne, D.B. & Stoessl, A.J. (2000). In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson’s disease. Annals of Neurology, 47, 493–503.

    Article  PubMed  CAS  Google Scholar 

  • Leenders, K.L., Palmer, A.J., Quinn, N., Clark, J.C., Firnau, G., Garnett, E.S., Nahmias, C., Jones, T. & Marsden, C.D. (1986). Brain dopamine metabolism in patients with Parkinson’s disease measured with positron emission tomography. Journal of Neurology, Neurosurgery and Psychiatry, 49, 853–860.

    Article  CAS  Google Scholar 

  • Marek, K.L., Seibyl, J.P., Zoghbi, S.S., Zea-Ponce, Y., Baldwin, R.M., Fussell, B., Charney, D.S., Dyck, C. van, Hoffer, P.B. & Innis, R.P. (1996). [123I] beta-cit/spect imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson’s disease. Neurology, 46, 231–237.

    Article  PubMed  CAS  Google Scholar 

  • Martin, W.R.W., Palmer, M.R., Patlak, C.S. & Calne, D.B. (1989). Nigrostriatal Function in Humans Studied with Positron Emission Tomography. Annals of Neurology, 26, 535–542.

    Article  PubMed  CAS  Google Scholar 

  • Morrish, P.K., Sawle, G.V. & Brooks, D.J. (1995). Clinical and [18F] dopa pet findings in early Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 59, 597–600.

    Article  CAS  Google Scholar 

  • Niznik, H.B., Fogel, E.F., Fassos, F.F. & Seeman, P. (1991). The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus. Journal of Neurochemistry, 56, 192–198.

    Article  PubMed  CAS  Google Scholar 

  • Ota, M., Yasuno, F., Ito, H., Seki, C., Nozaki, S., Asada, T. & Suhara, T. (2006). Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[beta-11C]dopa. Life Science, 79, 730–736.

    Article  CAS  Google Scholar 

  • Paulus, W. & Jellinger, K. (1991). The neuropathologic basis of different clinical subgroups of Parkinson’s disease. Journal of Neuropathology and Experimental Neurology, 50, 743–755.

    Article  PubMed  CAS  Google Scholar 

  • Pirker, W. (2003). Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it? Movement Disorders, 18, Supplement 7, S43–S51.

    Article  PubMed  Google Scholar 

  • Ryding, E., Lindstrom, M., Bradvik, B., Grabowski, M., Bosson, P., Traskman-Bendz, L. & Rosen, I. (2004). A new model for separation between brain dopamine and serotonin transporters in I-123-beta-cit spect measurements: normal values and sex and age dependence. European Journal of Nuclear Medicine and Molecular Imaging, 31, 1114–1118.

    Article  PubMed  CAS  Google Scholar 

  • Sawle, G.V., Colebatch, J.G., Shah, A., Brooks, D.J., Marsden, C.D. & Frackowiak, R.S.J. (1990). Striatal Function in Normal Aging - Implications for Parkinson’s-Disease. Annals of Neurology, 28, 799–804.

    Article  PubMed  CAS  Google Scholar 

  • Seibyl, J.P., Marek, K., Sheff, K., Zoghbi, S., Baldwin, R.M., Charney, D.S. Dyck, C.H. van & Innis, R.B. (1998). Iodine-123-beta-cit and iodine-123-fpcit spect measurement of dopamine transporters in healthy subjects and Parkinson’s patients. Journal of Nuclear Medicine, 39, 1500–1508.

    PubMed  CAS  Google Scholar 

  • Seibyl, J.P., Marek, K.L., Quinlan, D., Sheff, K., Zoghbi, S., Zea-Ponce, Y., Baldwin, R.M., Fussell, B., Smith, E.O., Charney, D.S., et al. (1995). Decreased single-photon emission computed tomographic [123I]beta-cit striatal uptake correlates with symptom severity in Parkinson’s disease. Annals of Neurology, 38, 589–598.

    Article  PubMed  CAS  Google Scholar 

  • Staley, J.K., Krishnan-Sarin, S., Zoghbi, S., Tamagnan, G., Fujita, M., Seibyl, J.P., Maciejewski, P.K., O’Malley, S. & Innis, R.B. (2001). Sex differences in [I-123]beta-cit spect measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse, 41, 275–284.

    Article  PubMed  CAS  Google Scholar 

  • Tissingh, G., Bergmans, P., Booij, J., Winogrodzka, A., Royen, E.A. van, Stoof, J.C. & Wolters, E.C. (1998). Drug-naive patients with Parkinson’s disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]beta-cit spect. Journal of Neurology, 245, 14–20.

    Article  PubMed  CAS  Google Scholar 

  • Vingerhoets, F.J.G., Snow, B.J., Schulzer, M., Morrison, S., Ruth, T.J., Holden, J.E., Cooper, S. & Calne, D.B. (1994). Reproducibility of Fluorine-18-6-Fluorodopa Positron Emission Tomography in Normal Human-Subjects. Journal of Nuclear Medicine, 35, 18–24.

    PubMed  CAS  Google Scholar 

  • Volkow, N.D., Ding, Y.S., Fowler, J.S., Wang, G.J., Logan, J., Gatley, S.J., Hitzemann, R., Smith, G., Fields, S.D. & Gur, R. (1996). Dopamine transporters decrease with age. C 37, 554–559.

    CAS  Google Scholar 

  • Weintraub, D., Newberg, A.B., Cary, M.S., Siderowf, A.D., Moberg, P.J., Kleiner-Fisman, G., Duda, J.E., Stern, M.B., Mozley, D. & Katz, I.R. (2005). Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson’s disease. Journal of Nuclear Medicine, 46, 227–232.

    PubMed  CAS  Google Scholar 

  • Winogrodzka, A., Bergmans, P., Booij, J., Royen, E.A. van, Stoof, J.C. & Wolters, E.C. (2003). [(123)I]beta-cit spect is a useful method for monitoring dopaminergic degeneration in early stage Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 74, 294–298.

    Article  CAS  Google Scholar 

  • Zigmond, M.J., Berger, T.W., Grace, A.A. & Stricker, E.M. (1989). Compensatory responses to nigrostriatal bundle injury. Studies with 6-hydroxydopamine in an animal model of parkinsonism. Molecular and Chemical Neuropathology, 10, 185–200.

    Article  PubMed  CAS  Google Scholar 

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  1. Afdeling Nucleaire Geneeskunde en Moleculaire Beeldvorming, Universitair Medisch Centrum Groningen, Hanzeplein 1, Postbus 30001, 9700 RB, Groningen, The Netherland

    Silvia Eshuis

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  1. Silvia Eshuis
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Eshuis, S. De rol van presynaptische dopaminerge beeldvorming bij de ziekte van Parkinson. NEUROPRAXIS 14, 10–15 (2010). https://doi.org/10.1007/s12474-010-0003-4

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