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Insulin-induced weight gain, often occurring over the first 9-12 months after starting insulin in patients with type 2 diabetes (T2DM), is obviously undesirable in an already overweight population and may offset the beneficial effects of insulin. We hypothesized that addition of liraglutide may be especially effective in reversing body weight in patients with pronounced insulin-associated weight gain while preserving glycemic control. This hypothesis was tested in a randomized controlled trial (ELEGANT).
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Nijmegen, Netherlands, ‘s-Hertogenbosch, Netherlands
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de Wit, H., Vervoort, G., Jansen, H. et al. 26. Liraglutide Reverses Pronounced Insulin-Associated Weight Gain, Improves Glycemic Control, and Decreases Insulin Dose in Patients with Type 2 Diabetes (973-P). NED. TIJDSCHR. DIABET. 12, 29 (2014). https://doi.org/10.1007/s12467-014-0051-0
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DOI: https://doi.org/10.1007/s12467-014-0051-0