Skip to main content
SpringerLink
Log in

PS14 - 73. Effect of fasting on energy- and nutrient-sensing pathways in human skeletal muscle

  • Published:
Nederlands Tijdschrift voor Diabetologie Aims and scope

Abstract

During fasting, rapid metabolic adaptations, such as a shift from carbohydrate to lipid oxidation, are required to maintain whole-body energy homeostasis. This mainly occurs by tissue-specific coordinated regulation of several nutrient and energy-sensitive pathways. Animal studies suggest that activation of the AMP-activated kinase (AMPK) triggers transcriptional modulation of genes involved in lipid and glucose metabolism. Sirtuin-1 (SIRT1) and histone deacetylase 4 (HDAC4) were recently proposed to play a central role in this AMPK-mediated transcriptional regulation of energy metabolism. Our aim is therefore to investigate the effects of fasting on AMPK/SIRT1/HDAC4 signaling pathways in human skeletal muscle.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Author information

Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands

    Marjolein A. Wijngaarden & Hanno Pijl

  2. Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

    Leontine E.H. Bakker & Ingrid Jazet

  3. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

    Ko Willems van Dijk

  4. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

    Bruno Guigas

Authors
  1. Marjolein A. Wijngaarden
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Leontine E.H. Bakker
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ko Willems van Dijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ingrid Jazet
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hanno Pijl
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bruno Guigas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marjolein A. Wijngaarden.

Additional information

1Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands; 2Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands; 3Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; 4Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands E-mail: m.a.wijngaarden@lumc.nl. *) Authors contributed equally to this work.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wijngaarden, M., Bakker, L., van Dijk, K. et al. PS14 - 73. Effect of fasting on energy- and nutrient-sensing pathways in human skeletal muscle. NED. TIJDSCHR. DIABET. 9, 140 (2011). https://doi.org/10.1007/s12467-011-0098-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12467-011-0098-0

Keywords

Search

Navigation