Skip to main content
Log in

Endometriumcarcinoom, nieuwe ontwikkelingen

  • Nascholing
  • Published:
Huisarts en wetenschap Aims and scope

Samenvatting

Lok C, Trum H. Endometriumcarcinoom, nieuwe ontwikkelingen. Huisarts Wet 2013;56(8):404-7.

Het endometriumcarcinoom is de meest voorkomende maligniteit van de vrouwelijke geslachtsorganen. De ziekte doet zich meestal voor na de menopauze, vaak met abnormaal bloedverlies als eerste symptoom. Als de tumor in een vroeg stadium wordt ontdekt – wat vaak het geval is –, is de prognose gunstig, maar de vijfjaarsoverleving daalt sterk in hogere stadia. De hoeksteen van de behandeling is (laparoscopische) verwijdering van de uterus, de adnexen en eventueel de bekkenlymfeklieren, zo nodig gevolgd door bestraling.

Een patiënte die wegens abnormaal bloedverlies bij de dokter komt, moet altijd gynaecologisch onderzocht worden. Verder is het zaak bedacht te zijn op een genetische predispositie en te vragen of darmkanker en endometriumcarcinomen vaker voorkomen in de familie.

Samenvatting

Lok C, Trom H. Endometrial cancer: new developments. Huisarts Wet 2013;56(8):404-7.

Endometrial cancer is the most common cancer of the female genital tract. The disease mainly occurs after the menopause, with abnormal blood loss as the first symptom. If the tumour is discovered in an early stage, which is often the case, the prognosis is favourable, but the 5-year survival decreases strongly with higher-stage disease. In the first instance, treatment consists of the laparoscopic removal of the uterus and adnexa and, if necessary, the pelvic lymph nodes, followed by radiotherapy if indicated. General practitioners should perform a gynaecological investigation in all women presenting with abnormal blood loss. They should also be aware of a possible genetic predisposition and ask patients whether they have a family history of bowel or endometrial cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figuur

Literatuur

  1. Nederlandse Kankerregistratie [internet]. Utrecht: IKNL, 2013. http://www.cijfersoverkanker.nl, geraadpleegd juni 2013.

  2. Diagnostiek bij abnormaal vaginaal bloedverlies in de postmenopauze: Versie 2.0. Utrecht: NVOG, 2003. http://www.nvog.nl, geraadpleegd juni 2013.

  3. Burke W, Petersen G, Lynch P, Botkin J, Daly M, Garber J, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. JAMA 1997;277:915-9.

    Article  PubMed  CAS  Google Scholar 

  4. Dijkhuizen FP, Mol BW, Brölmann HA, Heintz AP. The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia: a meta-analysis. Cancer 2000;89:1765-72.

    Article  PubMed  CAS  Google Scholar 

  5. Endometriumcarcinoom: Landelijke richtlijn [internet]. Utrecht: IKNL, 2011. http://www.oncoline.nl, geraadpleegd juni 2013.

  6. Obermair A, Janda M, Baker J, Kondalsamy-Chennakesavan S, Brand A, Hogg R, et al. Improved surgical safety after laparoscopic compared to open surgery for apparent early stage endometrial cancer: results from a randomised controlled trial. Eur J Cancer 2012;48:1147-53.

    Article  PubMed  Google Scholar 

  7. Galaal K, Bryant A, Fisher AD, Al-Khaduri M, Kew F, Lopes AD. Laparoscopy versus laparotomy for the management of early stage endometrial cancer. Cochrane Database Syst Rev 2012;(9):CD006655.

  8. Bijen CB, Vermeulen KM, Mourits MJ, Arts HJ, Ter Brugge HG, Van der Sijde R, et al. Cost effectiveness of laparoscopy versus laparotomy in early stage endometrial cancer: a randomised trial. Gynecol Oncol 2011;121:76-82.

    Article  PubMed  Google Scholar 

  9. Bijen CB, De Bock GH, Vermeulen KM, Arts HJ, Ter Brugge HG, Van der Sijde R, et al.. Laparoscopic hysterectomy is preferred over laparotomy in early endometrial cancer patients, however not cost effective in the very obese. Eur J Cancer 2011;47:2158-65.

    Article  PubMed  Google Scholar 

  10. Janda M, Gebski V, Brand A, Hogg R, Jobling TW, Land R, et al. Quality of life after total laparoscopic hysterectomy versus total abdominal hysterectomy for stage I endometrial cancer (LACE): a randomised trial. Lancet Oncol. 2010;11:772-80.

    Article  PubMed  Google Scholar 

  11. Kondalsamy-Chennakesavan S, Janda M, Gebski V, Baker J, Brand A, Hogg R, et al. Risk factors to predict the incidence of surgical adverse events following open or laparoscopic surgery for apparent early stage endometrial cancer: results from a randomised controlled trial. Eur J Cancer 2012;48:2155-62.

    Article  PubMed  Google Scholar 

  12. May K, Bryant A, Dickinson HO, Kehoe S, Morrison J. Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev 2010;(1):CD007585.

  13. Walker JL, Piedmonte MR, Spirtos NM, Eisenkop SM, Schlaerth JB, Mannel RS, et al. Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study. J Clin Oncol 2012;30:695-700.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christianne Lok.

Additional information

gynaecoloog

gynaecologisch oncoloog (beiden tevens VUmc Cancer Center Amsterdam)

• Mogelijke belangenverstrengeling: niets aangegeven.

Dit nascholingsartikel is een aflevering in de serie ‘Oncologie’.

About this article

Cite this article

Lok, C., Trum, H. Endometriumcarcinoom, nieuwe ontwikkelingen. HUISARTS WETENSCHAP 56, 404–407 (2013). https://doi.org/10.1007/s12445-013-0211-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12445-013-0211-2

Navigation