Van verzadigd naar onverzadigd vet

Samenvatting

Hornstra G, Grooten HNA, Van Binsbergen JJ. Van verzadigd naar onverzadigd vet. Huisarts Wet 2012;55(2):64–7.

Wat is de rol van voeding bij de selectieve en zorggerelateerde preventie van hart- en vaatziekten en diabetes mellitus type 2? Welke rol spelen de verschillende vetten daarbij? Het advies van de Gezondheidsraad luidt vooral om minder verzadigde vetten te eten. Uit de wetenschappelijke literatuur blijkt echter dat extra gezondheidswinst mogelijk is als men verzadigde vetten in de voeding vervangt door onverzadigde vetten. In dit artikel gaan we dieper in op de wetenschappelijke achtergronden van deze opvatting. Bij een normaal lichaamsgewicht is de vetkwaliteit van de voeding belangrijker dan de vetkwantiteit.

Abstract

Hornstra G, Grooten HNA, Van Binsbergen JJ. From saturated to unsaturated fat. Huisarts Wet 2012;55(2):64–7.

What is the role of diet in the prevention of cardiovascular diseases and diabetes mellitus type 2? And what is the role of the different types of fat? The Health Council of the Netherlands advises eating less saturated fat, but the scientific literature suggests that an additional health benefit can be achieved if people replace saturated fat in their diet with unsaturated fat. In this article, we go into the scientific basis for this. In normal-weight individuals, it is the quality rather than the quantity of dietary fat that is important.

This is a preview of subscription content, access via your institution.

Literatuur

  1. 1

    Gezondheidsraad. Voedingsnormen: energie, eiwitten, vetten en verteerbare koolhydraten. Den Haag: Gezondheidsraad, 2001; publicatie nr 2001/19R (gecorrigeerde editie: juni 2002).

  2. 2

    Gezondheidsraad. Richtlijnen goede voeding. Den Haag: Gezondheidsraad, 2006; publicatie 2006/21.

  3. 3

    Food and Agriculture Organization of the United Nations. Fats and fatty acids in human nutrition. Report of an expert consultation. Rome: FAO, 2010; FAO Food and Nutrition Paper 91.

  4. 4

    U.S. Department of Agriculture and U.S. Department of Health and Human Services. Dietary Guidelines for Americans, 2010. 7th Edition, Washington, DC: U.S. Government Printing Office, December 2010.

  5. 5

    Hulshof KFAM, Ocké MC, Van Rossum CTM, Buurma-Rethaus EJM, Brants HAM, Drijvers JJMM, et al. Resultaten van de voedselconsumptiepeiling 2003. Bilthoven: RIVM, 2004; RIVM-rapport 350030002/2004.

  6. 6

    Kruizinga AG, Westenbrink S, Van Bosch LMC, Jansen MCJF. De inneming van omega-3 en -6 vetzuren van vitamines A, D en E bij jongvolwassenen. Aanvullende berekeningen op basis van Voedselconsumptiepeiling 2003. Bilthoven: RIVM, 2007; TNO-rapport V7451.

  7. 7

    Ravnskov U. Cholesterol was healthy in the end. World Rev Nutr Diet 2009;100:90–209.

    PubMed  CAS  Article  Google Scholar 

  8. 8

    Thompson GR. History of the cholesterol controversy in Britain. QJM 2009;102:81–6.

    PubMed  CAS  Article  Google Scholar 

  9. 9

    Mensink RP, Zock PL, Kester ADM, Katan MB. Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials. Am J Clin Nutr 2003;77:1146–53.

    PubMed  CAS  Google Scholar 

  10. 10

    Jakobsen MU, O’Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, et al. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr 2009;89:1425–32.

    PubMed  CAS  Article  Google Scholar 

  11. 11

    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010;91:535–46.

    PubMed  CAS  Article  Google Scholar 

  12. 12

    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr 2010;91:502–9.

    PubMed  CAS  Article  Google Scholar 

  13. 13

    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep 2010;12:384–90.

    PubMed  CAS  Article  Google Scholar 

  14. 14

    Mozaffarian D, Micha R, Wallace S. Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: A systematic review and meta-analysis of randomized controlled trials. PLoS Med 2010;7:e1000252.

    PubMed  Article  Google Scholar 

  15. 15

    Bendsen NT, Christensen R, Bartels EM, Astrup A. Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies. Eur J Clin Nutr 2011;65:773–83.

    PubMed  CAS  Article  Google Scholar 

  16. 16

    Brouwer IA, Wanders AJ, Katan MB. Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans – a quantitative review. PloS One 2010;5:e9434.

    PubMed  Article  Google Scholar 

  17. 17

    Hunter JE, Zhang J, Kris-Etherton PM. Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review. Am J Clin Nutr 2010;91:46–63.

    PubMed  CAS  Article  Google Scholar 

  18. 18

    Burdge GC, Calder PC. Dietary alpha-linolenic acid and health-related outcomes: A metabolic perspective. Nutr Res Rev 2006;19:26–52.

    PubMed  CAS  Article  Google Scholar 

  19. 19

    Albert CM, Oh K, Whang W, Manson JE, Chae CU, Stampfer MJ, et al. Dietary alpha-linolenic acid intake and risk of sudden cardiac death and coronary heart disease. Circulation 2005;112:3232–8.

    PubMed  CAS  Article  Google Scholar 

  20. 20

    Oomen CM, Ocké MC, Feskens EJ, Kok FJ, Kromhout D. Alpha-linolenic acid intake is not beneficially associated with 10-y risk of coronary artery disease incidence: The Zutphen elderly study. Am J Clin Nutr 2001;74:457–63.

    PubMed  CAS  Google Scholar 

  21. 21

    Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, et al. N-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: A systematic review. Am J Clin Nutr 2006;84:5–17.

    PubMed  CAS  Google Scholar 

  22. 22

    Lemaitre RN, King IB, Sotoodehnia N, Rea TD, Raghunathan TE, Rice KM, et al. Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest. Metabolism 2009;58:534–40.

    PubMed  CAS  Article  Google Scholar 

  23. 23

    Harris WS, Kris-Etherton PM, Harris KA. Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults. Curr Atheroscler Rep 2008;10:503–9.

    PubMed  CAS  Article  Google Scholar 

  24. 24

    Jung UJ, Torrejon C, Tighe AP, Deckelbaum RJ. n-3 Fatty acids and cardiovascular disease: Mechanisms underlying beneficial effects. Am J Clin Nutr 2008;87:2003S–2009S.

    PubMed  CAS  Google Scholar 

  25. 25

    Risérus U, WC Willet, FB Hu. Dietary fats and prevention of type 2 diabetes. Progr Lipid Res 2009;48:44–51.

    Article  Google Scholar 

  26. 26

    Egert S, Fobker M, Andersen G, Somoza V, Erbersdobler HF, Wahrburg U. Effects of dietary α-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid on parameters of glucose metabolism in healthy volunteers. Ann Nutr Metab 2008;53:182–7.

    PubMed  CAS  Article  Google Scholar 

  27. 27

    Astrup A, Dyerberg J, Elwood P, Hermansen K, Hu FB, Jakobsen MU et al. The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr 2011;93:684–8.

    PubMed  CAS  Article  Google Scholar 

  28. 28

    Schickenberg B, Van Assema P, Brug J, Verkaik-Kloosterman J, Ocké MC, De Vries NK, et al. Replacing foods high in saturated fat by low-saturated fat alternatives: a computer simulation of the potential effects on reduction of saturated fat consumption. Br J Nutz 2009;102:478–83.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Additional information

emeritus hoogleraar Experimentele Voedingskunde

wetenschappelijk specialist voeding en gezondheid

huisarts, bijzonder hoogleraar Voedingsleer en Huisartsgeneeskunde

Mogelijke belangenverstrengeling: de auteurs zijn respectievelijk voorzitter, lid en adviseur van de Stuurgroep Kies Gezond Vet. Deze Stuurgroep wordt gefinancierd door het Productschap Margarine, Vetten en Oliën.

About this article

Cite this article

Hornstra, G., Grooten, H.N.A. & van Binsbergen, J.J. Van verzadigd naar onverzadigd vet. HUISARTS WETENSCHAP 55, 64–67 (2012). https://doi.org/10.1007/s12445-012-0035-5

Download citation