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Ouder worden met trisomie 21

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Bijblijven

Samenvatting

De levensverwachting van personen met trisomie 21 is spectaculair toegenomen. Meer volwassenen leven langer. De opvolging van kinderen met trisomie 21 gebeurt op systematische en gecoördineerde manier om op gezondheidsproblemen te anticiperen en tijdig te herkennen. Dat is bij volwassenen minder het geval. Gecoördineerde, systematische opvolging van de gezondheid van volwassenen met trisomie 21 wordt wel in de literatuur aanbevolen en kan een belangrijke impact hebben op de gezondheidstoestand en kwaliteit van leven. De huisarts bekleedt een ideale positie om deze zorg te coördineren. Deze bijdrage geeft een beknopt overzicht van de verschillende gezondheidsproblemen en een stelt een schema voor opvolging voor.

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Literatuur

  1. Bittles AH, Glasson EJ. Clinical, social, and ethical implications of changing life expectancy in Down syndrome. Dev Med Child Neurol. 2004;46:282–6.

    Article  CAS  PubMed  Google Scholar 

  2. Bittles AH, Bower C, Hussain R, Glasson EJ. The four ages of Down syndrome. Eur J Public Health 2007;17:221–5.

    Article  PubMed  Google Scholar 

  3. Real de Asua D, Quero M, Moldenhauer F, Suarez C. Clinical profile and main comorbidities of Spanish adults with Down syndrome. Eur J Intern Med. 2015;26:385–91.

    Article  PubMed  Google Scholar 

  4. Gardiner K. Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors. Behav Genet. 2006;36:439–53.

    Article  PubMed  Google Scholar 

  5. Nakamura E, Tanaka S. Biological ages of adult men and women with Down’s syndrome and its changes with aging. Mech Ageing Dev. 1998;105:89–103.

    Article  CAS  PubMed  Google Scholar 

  6. Esbensen AJ. Health conditions associated with aging and end of life of adults with Down syndrome. Int Rev Res Ment Retard. 2010;39:107–26.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Carfi A, Antocicco M, Brandi V, Cipriani C, Fiore F, Mascia D, et al. Characteristics of adults with down syndrome: prevalence of age-related conditions. Front Med. (Lausanne) 2014;1:51.

    Google Scholar 

  8. Smith DS. Health care management of adults with Down syndrome. Am Fam Physician. 2001;64:1031–8.

    CAS  PubMed  Google Scholar 

  9. Delle Chiaie B, Van den Braembussche S, Elsing C, Ent S van der, Leroy R, Callewaert B, et al. Adults with Down syndrome – health/care considerations for health professionals. Tijdschr Belg Kinderarts. 2012;14:56–61.

    Google Scholar 

  10. Jensen KM, Bulova PD. Managing the care of adults with Down’s syndrome. BMJ. 2014;349:g5596.

    Article  PubMed  Google Scholar 

  11. Henderson A, Lynch SA, Wilkinson S, Hunter M. Adults with Down’s syndrome: the prevalence of complications and health care in the community. Br J Gen Pract. 2007;57:50–5.

    PubMed  PubMed Central  Google Scholar 

  12. Bertoli M, Biasini G, Calignano MT, Celani G, De Grossi G, Digilio MC, et al. Needs and challenges of daily life for people with Down syndrome residing in the city of Rome, Italy. J Intellect Disabil Res. 2011;55:801–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Anwar AJ, Walker JD, Frier BM. Type 1 diabetes mellitus and Down’s syndrome: prevalence, management and diabetic complications. Diabet Med. 1998;15:160–3.

    Article  CAS  PubMed  Google Scholar 

  14. Seltzer GB, Schupf N, Wu HS. A prospective study of menopause in women with Down’s syndrome. J Intellect Disabil Res. 2001;45:1–7.

    Article  CAS  PubMed  Google Scholar 

  15. Patel BN, Seltzer GB, Wu HS, Schupf N. Effect of menopause on cognitive performance in women with Down syndrome. Neuroreport. 2001;12:2659–62.

    Article  CAS  PubMed  Google Scholar 

  16. Prasher VP. Overweight and obesity amongst Down’s syndrome adults. J Intellect Disabil Res. 1995;39 (Pt 5):437–41.

    Article  PubMed  Google Scholar 

  17. Lai F, Williams RS. A prospective study of Alzheimer disease in Down syndrome. Arch Neurol. 1989;46:849–53.

    Article  CAS  PubMed  Google Scholar 

  18. Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, et al. Onset of dementia is associated with age at menopause in women with Down’s syndrome. Ann Neurol. 2003;54:433–8.

    Article  PubMed  Google Scholar 

  19. Ball SL, Holland AJ, Hon J, Huppert FA, Treppner P, Watson PC. Personality and behaviour changes mark the early stages of Alzheimer’s disease in adults with Down’s syndrome: findings from a prospective population-based study. Int J Geriatr Psychiatry 2006;21:661–73.

    Article  PubMed  Google Scholar 

  20. Lott IT, Dierssen M. Cognitive deficits and associated neurological complications in individuals with Down’s syndrome. Lancet Neurol. 2010;9:623–33.

    Article  PubMed  Google Scholar 

  21. Gedye A. Dementia Scale for Down’s Syndrome. Vancouver: Gedye Research and Consulting; 1995.

  22. Strydom A, Hassiotis A. Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging Ment Health 2003;7:431–37.

    Article  CAS  PubMed  Google Scholar 

  23. Lott IT, Doran E, Nguyen VQ, Tournay A, Movsesyan N, Gillen DL. Down syndrome and dementia: seizures and cognitive decline. J Alzheimers Dis. 2012;29:177–85.

    PubMed  PubMed Central  Google Scholar 

  24. Evenhuis HM. The natural history of dementia in Down’s syndrome. Arch Neurol. 1990;47:263–7.

    Article  CAS  PubMed  Google Scholar 

  25. De Simone R, Puig XS, Gelisse P, Crespel A, Genton P. Senile myoclonic epilepsy: delineation of a common condition associated with Alzheimer’s disease in Down syndrome. Seizure 2010;19:383–9.

    Article  PubMed  Google Scholar 

  26. Aller-Alvarez JS, Menendez-Gonzalez M, Ribacoba-Montero R, Salvado M, Vega V, Suarez-Moro R, et al. Myoclonic epilepsy in Down syndrome and Alzheimer disease. Neurologia 2015. doi:10.1016/j.nrl.2014.12.008

  27. Sobey CG, Judkins CP, Sundararajan V, Phan TG, Drummond GR, Srikanth VK. Risk of Major Cardiovascular Events in People with Down Syndrome. PLoS One 2015;10:e0137093.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Coppus AM, Evenhuis HM, Verberne GJ, Visser FE, Oostra BA, Eikelenboom P, et al. Survival in elderly persons with Down syndrome. J Am Geriatr Soc. 2008;56:2311–16.

    Article  PubMed  Google Scholar 

  29. Uppal H, Chandran S, Potluri R. Risk factors for mortality in Down syndrome. J Intellect Disabil Res. 2015;59:873–81.

    Article  CAS  PubMed  Google Scholar 

  30. Trois MS, Capone GT, Lutz JA, Melendres MC, Schwartz AR, Collop NA, et al. Obstructive sleep apnea in adults with Down syndrome. J Clin Sleep Med. 2009;5:317–23.

    PubMed  PubMed Central  Google Scholar 

  31. Lal C, Strange C, Bachman D. Neurocognitive impairment in obstructive sleep apnea. Chest 2012;141:1601–10.

    Article  PubMed  Google Scholar 

  32. Elsing C, Ent S van der. Systematische gezondheidsfollow-up van volwassenen met Downsyndroom met een Downpas 18 +. University of Antwerp. Unpublished Work; 2013.

  33. Juj H, Emery H. The arthropathy of Down syndrome: an underdiagnosed and under-recognized condition. J Pediatr. 2009;154:234–8.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. dienst Neurologie, Universitair Ziekenhuis Antwerpen, Universiteit Antwerpen, Edegem, België

    Gert Van Goethem MD, PhD

  2. Centrum Huisartsgeneeskunde Universiteit Antwerpen, Wilrijk, België

    Peter Dieleman

  3. dienst Kindergeneeskunde, Universitair Ziekenhuis Antwerpen, Universiteit Antwerpen, Edegem, België

    Marek Wojciechowski

Authors
  1. Gert Van Goethem MD, PhD
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  2. Peter Dieleman
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  3. Marek Wojciechowski
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Correspondence to Marek Wojciechowski.

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Van Goethem, G., Dieleman, P. & Wojciechowski, M. Ouder worden met trisomie 21. Bijblijven 32, 40–51 (2016). https://doi.org/10.1007/s12414-016-0112-y

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  • DOI: https://doi.org/10.1007/s12414-016-0112-y

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