Skip to main content
SpringerLink
Log in

Het feochromocytoom

  • Published:
Bijblijven

Samenvatting

Het feochromocytoom is een zeldzame maar gevaarlijke neuro-endocriene tumor van het bijniermerg of de extra-adrenale sympathische paraganglia. De klinische presentatie wordt met name bepaald door de cardiovasculaire effecten van catecholaminen. De laboratoriumdiagnostiek bestaat uit het bepalen van metanefrines in bloed of 24-uursurine. De laboratoriumdiagnostiek kan valspositief zijn door bepaalde medicijnen zoals anti-emetica en psychofarmaca. Tevens kunnen deze middelen bij feochromocytoom een catecholaminecrisis veroorzaken. De behandeling bestaat uit tumorresectie na zorgvuldige preoperatieve alfa- en bèta-adrenerge blokkade. Een derde van de patiënten heeft een onderliggend genetisch syndroom. Feochromocytoom mondt in een minderheid van de gevallen uit in gemetastaseerde ziekte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figuur 1
Figuur 2

Literatuur

  1. Lenders JW, Eisenhofer G, Mannelli M, Pacak K. Phaeochromocytoma. Lancet. 2005;366(9486):665–75.

    Article  PubMed  Google Scholar 

  2. DeLellis RA, Lloyd RV, Heitz PU, Eng C. Tumours of endocrine organs. Lyon: IARC Press; 2004.

    Google Scholar 

  3. Omura M, Saito J, Yamaguchi K, Kakuta Y, Nishikawa T. Prospective study on the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinic in Japan. Hypertens Res. 2004;27(3):193–202.

    Article  PubMed  Google Scholar 

  4. Wyszynska T, Cichocka E, Wieteska-Klimczak A, Jobs K, Januszewicz P. A single pediatric center experience with 1025 children with hypertension. Acta Paediatr. 1992;81(3):244–6.

    Article  CAS  PubMed  Google Scholar 

  5. Lenders JW, Duh QY, Eisenhofer G, Gimenez-Roqueplo AP, Grebe SK, Murad MH, et al. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metabol. 2014;99(6):1915–42. Epub 2014/06/04.

    Article  CAS  Google Scholar 

  6. Pacak K. Preoperative management of the pheochromocytoma patient. J clin endocrinol metabol. 2007;92(11):4069–79.

    Article  CAS  Google Scholar 

  7. Mansmann G, Lau J, Balk E, Rothberg M, Miyachi Y, Bornstein SR. The clinically inapparent adrenal mass: update in diagnosis and management. Endocr Rev. 2004;25(2):309–40.

    Article  PubMed  Google Scholar 

  8. Lenders JW, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, et al. Biochemical diagnosis of pheochromocytoma: which test is best? JAMA. 2002;287(11):1427–34.

    Article  CAS  PubMed  Google Scholar 

  9. Berkel A van, Lenders JW, Timmers HJ. Diagnosis of endocrine disease: biochemical diagnosis of phaeochromocytoma and paraganglioma. Eur J Endocrinol. 2014;170(3):R109–19. Epub 2013/12/19.

    Article  PubMed  Google Scholar 

  10. Eisenhofer G, Goldstein DS, Walther MM, Friberg P, Lenders JW, Keiser HR, et al. Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results. J Clin Endocrinol Metabol. 2003;88(6):2656–66.

    Article  CAS  Google Scholar 

  11. Timmers HJ, Taieb D, Pacak K. Current and future anatomical and functional imaging approaches to pheochromocytoma and paraganglioma. Horm Metab Res. 2012;44(5):367–72. Epub 2012/03/09.

    Article  CAS  PubMed  Google Scholar 

  12. Favier J, Amar L, Gimenez-Roqueplo A. Paraganglioma and phaeochromocytoma: from genetics to personalized medicine. Nat Rev Endocrinol. 2015;11(2):101–11. Epub 2014/11/12.

    Article  CAS  PubMed  Google Scholar 

  13. Timmers HJ, Kozupa A, Eisenhofer G, Raygada M, Adams KT, Solis D, et al. Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas. J Clin Endocrinol Metab. 2007;92(3):779–86.

    Article  CAS  PubMed  Google Scholar 

  14. Amar L, Baudin E, Burnichon N, Peyrard S, Silvera S, Bertherat J, et al. Succinate dehydrogenase B gene mutations predict survival in patients with malignant pheochromocytomas or paragangliomas. J Clin Endocrinol Metab. 2007;92(10):3822–8.

    Article  CAS  PubMed  Google Scholar 

  15. Baudin E, Habra MA, Deschamps F, Cote G, Dumont F, Cabanillas M, et al. Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma. Eur J Endocrinol. 2014;171(3):R111–22. Epub 2014/06/04.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Afdeling Interne Geneeskunde, sectie Endocriene Ziekten, Radboudumc, Nijmegen, Nederland

    Henri J.L.M. Timmers

Authors
  1. Henri J.L.M. Timmers
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Henri J.L.M. Timmers.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Timmers, H. Het feochromocytoom. Bijblijven 31, 290–298 (2015). https://doi.org/10.1007/s12414-015-0035-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12414-015-0035-z

Search

Navigation