Samenvatting
In de huisartsenpraktijk neemt het aantal patiënten met een verminderde nierfunctie toe. Veel geneesmiddelen worden renaal uitgescheiden, wat onder andere consequenties heeft voor de dosering van deze geneesmiddelen. Het is in de dagelijkse praktijk niet altijd gemakkelijk hiermee om te gaan. In deze bijdrage gaan we dieper in op de beoordeling van de nierfunctie en geven we vervolgens achtergrondinformatie en praktische adviezen omtrent het gebruik van antibiotica, orale antidiabetica, ACE-remmers, NSAID’s, diuretica en de nieuwe directe orale anticoagulantia (DOAC) bij nierinsufficiëntie.
Literatuur
Harm-rapport (Hospital Admissions Related to Medication). Utrecht: Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology & Pharmacotherapy, November 2006.
Leendertse AJ, Dijk EA van, Smet PA de, Egberts TC, Bemt PM van den. Contribution of renal impairment to potentially preventable medication-related hospital admissions. Ann Pharmacother 2012 May;46(5):625–33.
Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P. Predictive performance of the modification of diet in renal disease and Cockroft-Gault equations for estimating renal function. J Am Soc Nephrol 2005;16:763–73.
Verhave JC, Kramers C, Wetzels JFM. Nieuwe formule leidt tot betere schattingen. Pharm Weekbl 2007;142(40):18–21.
Felts JH, Hayes DM, Gergen JA, Toole JF. Neural, hematologic and bacteriologic effects of nitrofurantoin in renal insufficiency. Am J Med 1971;51:331–9.
Thieler H, Meyer W. Nil nocere! Severe polyneuropathy during nitrofurantoin therapy of renal insufficiency. Dtsch Gesundheitsw 1968;23:488–91.
Geerts AF, et al. Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care. Eur J Clin Pharmacol 2013 Sep;69(9):1701–7.
Siber GR, Gorham CC, Ericson JF, Smith AL. Pharmacokinetics of intravenous trimethoprim-sulfamethoxazole in children and adults with normal and impaired renal function. Rev Infect Dis 1982 Mar-Apr;4(2):566–78.
Rigalleau V, et al. Estimation of renal function in patients with diabetes. Diabetes Metab 2011;37(5):359–66.
Linden CMJ van der, Knol W, Marum RJ van, Jansen PA. Lactaatacidose bij een 85-jarige vrouw door behandeling met metformine. Ned Tijdschr Geneeskd 2007;151:977–80.
Howlett HC, Bailey CJ. A risk-benefit assessment of metformin in type 2 diabetes mellitus. Drug Saf 1999:489–503.
Graham GG, et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 2011;50 (2):81–98.
Jönsson A, Rydberg T, Sterner G, Melander A. Pharmacokinetics of glibenclamide and its metabolites in diabetic patients with impaired renal function. Eur J Clin Pharmacol 1998;53:429–35.
Rosenkranz B, Profozic V, Metelko Z, Mrzljak V, Lange C, Malerczyk V. Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment. Diabetologia 1996;39:1617–24.
Marbury TC, et al. Pharmacokinetics of repaglinide in subjects with renal impairment.Clin Pharmacol Ther 2000 Jan;67(1):7–15.
Lam FYW, Banerji S, Hatfield C, Talbert RL. Principles of drug administration in renal insufficiency. Clin Pharmocokinet 1997 Jan;32 (1):30–57.
Boulton D, et al. Influence of renal or hepatic impairment on the pharmacokinetics of saxagliptin. Clin Pharmacokinet 2011 Apr;50(4):253–65.
Lukashevich V, Schweizer A, Shao Q, Groop PH, Kothny W. Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial. Diabetes Obes Metab 2011;13:947–54.
Bergman AJ, et al. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care 2007;30:1862–4.
Linneberg H, et al. Effect of renal impairment on the pharmacokinetics of exenatide. Br J Clin Pharmacol 2007;64:317–27.
Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M. Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol 2009 Dec;68(6):898–905.
Bootsma JE, et al. Adherence to biochemical monitoring recommendations in patients starting with renin angiotensin system inhibitors: a retrospective cohort study in the Netherlands. Drug Saf 2011 Jul 1;34(7):605–14.
Whelton A. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med 1999 May 31;106(5B):13S-24S.
Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. New Engl J Med 1984;310:563–72.
Niemeyer C, Hasenfuss G, Wais U, Knauf H, Schäfer-Korting M, Mutschler E. Pharmacokinetics of hydrochloorthiazide in relation to renal function. Eur J Clin Pharmacol 1983;24:661–5.
Traeger A, et al. Pharmacokinetic and pharmacodynamic effects of furosemide in patients with impaired renal function. Int J Clin Pharmacol Ther Toxicol 1984;22(9):481–6.
Syropoulus AC, Douketis JD. How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood 2012;120(15):2954–62.
Steffel J, Hindrick G. Apixaban in renal insufficiency: successful navigation between the Scylla and Charybdis. Eur Heart J 2012;33:2766–8.
Author information
Authors and Affiliations
Additional information
internist in opleiding – klinisch farmacoloog in opleiding, Radboudumc, Nijmegen
huisarts en hoofd Eerstelijnsvervolgopleidingen, Radboudumc Nijmegen
internist-klinisch farmacoloog, Canisius-Wilhelmina ziekenhuis en Radboudumc, Nijmegen
Rights and permissions
About this article
Cite this article
Esselink, A., Scherpbier-de Haan, N. & Kramers, K. Nierinsufficiëntie en medicatie. Bijblijven 30, 54–60 (2014). https://doi.org/10.1007/s12414-014-0024-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12414-014-0024-7