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Oxygenation and Flow in the Limbs: Novel Methods to Characterize Peripheral Artery Disease

  • Cardiac Magnetic Resonance (E Nagel, Section Editor)
  • Published:
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Abstract

Peripheral artery disease (PAD) affects approximately 8 million Americans and is associated with high morbidity and increased mortality. Current therapies for PAD are limited and development of new therapeutic agents is needed. Present diagnostic methods for PAD are insensitive to the subtle microvascular and metabolic changes that occur beyond macrovacular stenosis and therefore may be less useful endpoints for clinical trials. Phosphorus-31 magnetic resonance (MR) spectroscopy, MR muscle perfusion, and MR oximetry are novel methods capable of evaluating both the macrovascular and microvascular changes that occur in PAD patients.

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Acknowledgments

Supported by NIH R01 HL075792 (CMK) and 5T32EB003841 (DL).

Disclosure

Dr. Kramer receives research support from Siemens Healthcare.

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Authors and Affiliations

  1. Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA

    David Lopez & Christopher M. Kramer

  2. Department of Medicine and Radiology, and the Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, VA, USA

    Christopher M. Kramer

  3. Departments of Medicine and Radiology, University of Virginia Health System, Lee Street, Box 800170, Charlottesville, VA, 22908, USA

    Christopher M. Kramer

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Correspondence to Christopher M. Kramer.

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Lopez, D., Kramer, C.M. Oxygenation and Flow in the Limbs: Novel Methods to Characterize Peripheral Artery Disease. Curr Cardiovasc Imaging Rep 6, 150–157 (2013). https://doi.org/10.1007/s12410-013-9191-7

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  • DOI: https://doi.org/10.1007/s12410-013-9191-7

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