Abstract
The use of cardiac magnetic resonance (CMR) imaging has recently been demonstrated to be a useful adjunct in the evaluation of emergency department (ED) patients with acute chest pain. This modality allows the assessment of non-ischemic causes of chest pain, early ischemic changes (T2-weighted imaging for edema), resting and stress perfusion abnormalities, resting and stress wall motion abnormalities, and assessment for scar formation with delayed enhancement. This comprehensive information appears most useful when evaluating higher complexity patients such as those at intermediate or high risk for ACS. In these more complex patients, the use of CMR is supported by appropriateness criteria, and in recent studies appears to be a cost-effective alternative to inpatient evaluation when combined with observation unit care.
Similar content being viewed by others
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
National Hospital Ambulatory Medical Care Survey: 2008 Emergency Department Summary Tables. Available at: http://www.cdc.gov/nchs/data/ahcd/nhamcs_emergency/nhamcsed2008.pdf (accessed 4/11/2011).
Nagel E, Lehmkuhl HB, Bocksch W, et al. Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation. 1999;99:763–70.
Hendel RC, Patel MR, Kramer CM, et al. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol. 2006;48:1475–97.
• Cury RC, Shash K, Nagurney JT, et al. Cardiac magnetic resonance with T2-weighted imaging improves detection of patients with acute coronary syndrome in the emergency department. Circulation 2008;118:837–44. This article describes the ability of resting CMR imaging to detect myocardial infarctions prior to troponin elevations using T2-weighted and delayed-enhancement imaging.
Kwong RY, Schussheim AE, Rekhraj S, et al. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation. 2003;107:531–7.
• Eitel I, Friedrich MG. T2-weighted cardiovascular magnetic resonance in acute cardiac disease. Journal of Cardiovascular Magnetic Resonance (BioMed Central) 2011;13:13–23. This is a comprehensive review describing the use of T2-weighted imaging.
Hundley WG, Hamilton CA, Thomas MS, et al. Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiography. Circulation. 1999;100:1697–702.
Nandalur KR, Dwamena BA, Choudhri AF, et al. Diagnostic performance of stress cardiac magnetic resonance imaging in the detection of coronary artery disease: a meta-analysis. J Am Coll Cardiol. 2007;50:1343–53.
Hundley WG, Morgan TM, Neagle CM, et al. Magnetic resonance imaging determination of cardiac prognosis. Circulation. 2002;106:2328–33.
Schwitter J, Wacker CM, van Rossum AC AC, et al. MR-IMPACT: comparison of perfusion-cardiac magnetic resonance with single-photon emission computed tomography for the detection of coronary artery disease in a multicentre, multivendor, randomized trial. Eur Hear J. 2008;29:480–9. doi:10.1093/eurheartj/ehm617.
Ingkanisorn WP, Kwong RY, Bohme NS, et al. Prognosis of negative adenosine stress magnetic resonance in patients presenting to an emergency department with chest pain. J Am Coll Cardiol. 2006;47:1427–32.
Abdel-Aty H, Zagrosek A, Schulz-Menger J, et al. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation. 2004;109:2411–6.
Mahaffey KW, Puma JA, Barbagelata NA, et al. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: Results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) Trial. J Am Coll Cardiol. 1999;34:1711–20.
Ross AM, Gibbons RJ, Stone GW, et al. A Randomized, Double-Blinded, Placebo-Controlled Multicenter Trial of Adenosine as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction (AMISTAD-II). J Am Coll Cardiol. 2005;45:1775–80.
•• Korosoglou G, Elhmidi Y, Steen H, et al. Prognostic Value of High-Dose Dobutamine Stress Magnetic Resonance Imaging in 1,493 Consecutive Patients: Assessment of Myocardial Wall Motion and Perfusion. Journal of the American College of Cardiology 2010;56:1225–1234. This article describes the circumstances when stress wall motion, stress perfusion, or both together are preferred.
Hundley WG. The use of cardiovascular magnetic resonance to identify adverse cardiac prognosis: an important step in reducing image-related heath care expenditures. J Am Coll Cardiol. 2010;56:1244–6.
Miller CD, Hoekstra JW, Lefevbre C, et al. A randomized trial comparing stress cardiac mri to conventional testing among observation unit patients with chest pain, SAEM Abstracts. Academic Emergency Medicine. 2011;18:S4–249.
Lerakis S, McLean DS, Anadiotis AV, et al. Prognostic value of adenosine stress cardiovascular magnetic resonance in patients with low-risk chest pain. J Cardiovasc Magn Reson. 2009;11:37.
• Miller CD, Hwang W, Case D, et al. Stress CMR Imaging Observation Unit in the Emergency Department Reduces 1-Year Medical Care Costs in Patients With Acute Chest Pain: A Randomized Study for Comparison With Inpatient Care. JACC: Cardiovascular Imaging 2011;4:862–870. This article describes the cost effectiveness of CMR in intermediate-risk and high-risk patients with chest pain.
Miller CD, Hwang W, Hoekstra JW, et al. Stress cardiac magnetic resonance imaging with observation unit care reduces cost for patients with emergent chest pain: a randomized trial. Ann Emerg Med. 2010;56:209–219.e2.
Plein S, Greenwood JP, Ridgway JP, et al. Assessment of non-ST-segment elevation acute coronary syndromes with cardiac magnetic resonance imaging. J Am Coll Cardiol. 2004;44:2173–81.
Roes SD, Kelle S, Kaandorp TA, et al. Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction. Am J Cardiol. 2007;100:930–6.
Wu E, Ortiz JT, Tejedor P, et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart. 2008;94:730–6. doi:10.1136/hrt.2007.122622.
Acknowledgments
Funded in part by the Translational Science Institute of Wake Forest University School of Medicine; NIH grants 1 R21 HL097131-01A1 (Miller), 1 RO1 HL076438 (Hundley), and 1 R33 CA12196 (Hundley); and American Heart Association grant 0980008 N (Miller).
Disclosure
C. D. Miller: consultant to Breathquant Medical, LLC and Deep Breeze, research support from Siemens, and lecture support from Sanofi-Aventis; W. G. Hundley: consultant to Prova Images.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Miller, C.D., Hundley, W.G. Cardiac Magnetic Resonance in the Emergency Department to Evaluate Patients for Possible Acute Coronary Syndrome. Curr Cardiovasc Imaging Rep 5, 92–98 (2012). https://doi.org/10.1007/s12410-012-9123-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12410-012-9123-y