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Quantitative Assessment of Myocardial Perfusion MRI

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Abstract

Myocardial perfusion MRI is acquired with a T1-weighted dynamic MRI sequence. Fully quantitative analysis of myocardial perfusion MRI allows the absolute quantification of myocardial blood flow (MBF) through the use of complex mathematical modeling. There are essentially two main methods for quantification of absolute MBF: the linear time-invariant model and the compartment model. Maximized contrast-to-noise ratio and the reasonable linearity of signal intensity in blood and myocardium are crucial for the accuracy of absolute MBF quantification by MRI. Quantitative assessment of MBF permits an accurate and objective assessment of myocardial perfusion and perfusion reserve in patients. This is of particular significance in patients with coronary artery disease but will also provide a means for investigating globally altered MBF in patients with microvascular disease of the heart. Furthermore, quantification of MBF with magnetic resonance can provides us with an important tool for monitoring disease progression and measuring the response to therapeutic interventions.

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Authors and Affiliations

  1. King’s College London BHF Centre of Excellence, NIHR Biomedical Research Centre, Medical Research Centre, Guy’s and St. Thomas’ NHS Trust Foundation, Division of Imaging Science, The Rayne Institute, 4th Floor, Lambeth Wing, London, SE1 7EH, UK

    Masaki Ishida, Geraint Morton, Andreas Schuster, Eike Nagel & Amedeo Chiribiri

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  1. Masaki Ishida
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  2. Geraint Morton
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Correspondence to Masaki Ishida.

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Ishida, M., Morton, G., Schuster, A. et al. Quantitative Assessment of Myocardial Perfusion MRI. curr cardiovasc imaging rep 3, 65–73 (2010). https://doi.org/10.1007/s12410-010-9013-0

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