Relation Between Lung Dysfunction and Blood Cadmium and Lead Levels Among Welders

  • S. P. Cetintepe
  • S. B. Iritas
  • M. Gunduzoz
  • M. E. Alaguney
  • D. Wilson
  • C. Bal
  • O. H. Yilmaz
  • L. Tutkun
  • Eun-Kee Park
Original Paper
  • 38 Downloads

Abstract

Although welding is an industrial process with well-known health effects, the effects of heavy metal exposure on the respiratory system during welding are largely unknown. In this study, we investigated the correlation between blood lead and cadmium levels, and respiratory function among welders. The study investigates 207 male subjects who applied to Occupational Disease Hospital, Ankara, Turkey. These subjects were categorized into three groups: one, non-smoker office workers; and two exposed, non-smoker groups (n = 96) that comprised welders who had history of metal fume exposure for less and more than 4 h a day. Lung function test was performed on all groups. Correlations between blood cadmium and lead levels and lung function test were evaluated statistically. Forced vital capacity (FVC) % and forced expiratory volume in 1 s (FEV1) % increased, and FEV1/FVC ratio decreased in welders who were exposed to metal fumes for less than 4 h a day (p < 0.0001). The group that was exposed for more than 4 h/day had increased FVC % and decreased FEV1 % and FEV1/FVC ratio (p < 0.0001). Blood cadmium and lead levels were high in both the exposed groups (p < 0.0001). Welders who were exposed for more than 4 h/day had significantly decreased FVC %, FEV1 %, FEV1/FVC ratio, and peak expiratory flow (PEF) values (p < 0.0001). All lung function parameters (FVC, FEV1, FEV1/FVC, PEF) decreased in subjects with high blood cadmium levels (p < 0.0001). This study clearly shows the increased working hours of exposure to welding fumes and severity of metal exposure correlate with impaired lung functions.

Keywords

Blood Lung function Cadmium Lead Welder 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that there is no conflict of interest, this manuscript has not been published previously, and is not under submission elsewhere.

References

  1. Al-Otaibi ST (2014) Respiratory health of a population of welders. J Family Community Med 21(3):162–165CrossRefGoogle Scholar
  2. Antonini JM (2003) Health effects of welding. Crit Rev Toxicol 33(1):61–103CrossRefGoogle Scholar
  3. Bellinger DC (2011) The protean toxicities of lead: new chapters in a familiar story. Int J Environ Res Public Health 8(7):2593–2628CrossRefGoogle Scholar
  4. Bertin G, Averbeck D (2006) Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 88(11):1549–1559CrossRefGoogle Scholar
  5. Bradshaw LM, Fishwick D, Slater T, Pearce N (1998) Chronic bronchitis, work related respiratory symptoms, and pulmonary function in welders in New Zealand. Occup Environ Med 55(3):150–154CrossRefGoogle Scholar
  6. Castleman BI, Ziem GE (1994) American Conference of Governmental Industrial Hygienists: low threshold of credibility. Am J Ind Med 26(1):133–143CrossRefGoogle Scholar
  7. Jeffus LF (2012) Welding: principles and applications, 7th edn. Delmar Cengage Learning, Clifton ParkGoogle Scholar
  8. Coccini T, Barni S, Vaccarone R, Mustarelli P, Manzo L, Roda E (2013) Pulmonary toxicity of instilled cadmium-doped silica nanoparticles during acute and subacute stages in rats. Histol Histopathol 28(2):195–209Google Scholar
  9. Corradi M, Mutti A (2011) Metal ions affecting the pulmonary and cardiovascular systems. Met Ions Life Sci 8:81–105Google Scholar
  10. Fu H, Boffetta P (1995) Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data. Occup Environ Med 52(2):73–81CrossRefGoogle Scholar
  11. Fuortes L, Leo A, Ellerbeck PG, Friell LA (1991) Acute respiratory fatality associated with exposure to sheet metal and cadmium fumes. J Toxicol Clin Toxicol 29(2):279–283CrossRefGoogle Scholar
  12. Hayes JA, Snider GL, Palmer KC (1976) The evolution of biochemical damage in the rat lung after acute cadmium exposure. Am Rev Respir Dis 113(2):121–130Google Scholar
  13. IWGotEoCRt (2006) Humans, Inorganic and organic lead compounds. IARC Monogr Eval Carcinog Risks Hum 87:1–471Google Scholar
  14. Staffan Skerfving IA (2015) Handbook on the Toxicology of Metals, 4th edn. Elsevier, AmsterdamGoogle Scholar
  15. Jafari AJ, Assari MJ (2004) Respiratory effects from work-related exposure to welding fumes in Hamadan. Iran, Arch Environ Health 59(3):116–120CrossRefGoogle Scholar
  16. Jakubowski M, Abramowska-Guzik A, Szymczak W, Trzcinka-Ochocka M (2004) Influence of long-term occupational exposure to cadmium on lung function tests results. Int J Occup Med Environ Health 17(3):361–368Google Scholar
  17. Jayawardana P, Abeysena C (2009) Respiratory health of welders in a container yard, Sri Lanka. Occup Med (Lond) 59(4):226–229CrossRefGoogle Scholar
  18. Kauppinen T, Riala R, Seitsamo J, Hernberg S (1992) Primary liver cancer and occupational exposure. Scand J Work Environ Health 18(1):18–25CrossRefGoogle Scholar
  19. Husgafvel-Pursiainen K, Siemiatycki J (1990) Welding Fumes. IARC Monogr 49:40–49Google Scholar
  20. Korczynski RE (2000) Occupational health concerns in the welding industry. Appl Occup Environ Hyg 15(12):936–945CrossRefGoogle Scholar
  21. Laszlo G (2006) Standardisation of lung function testing: helpful guidance from the ATS/ERS Task Force. Thorax 61(9):744–746CrossRefGoogle Scholar
  22. Liao LM, Friesen MC, Xiang YB, Cai H, Koh DH, Ji BT, Yang G, Li HL, Locke SJ, Rothman N, Zheng W, Gao YT, Shu XO, Purdue MP (2016) Occupational lead exposure and associations with selected cancers: the Shanghai Men’s and Women’s Health Study Cohorts. Environ Health Perspect 124(1):97–103Google Scholar
  23. Loewenson RH (1998) Health impact of occupational risks in the informal sector in Zimbabwe. Int J Occup Environ Health 4(4):264–274CrossRefGoogle Scholar
  24. Marsh GM, Esmen NA, Buchanich JM, Youk AO (2009) Mortality patterns among workers exposed to arsenic, cadmium, and other substances in a copper smelter. Am J Ind Med 52(8):633–644CrossRefGoogle Scholar
  25. Nawrot TS, Martens DS, Hara A, Plusquin M, Vangronsveld J, Roels HA, Staessen JA (2015) Association of total cancer and lung cancer with environmental exposure to cadmium: the meta-analytical evidence. Cancer Causes Control 26(9):1281–1288CrossRefGoogle Scholar
  26. Palmer KC, Snider GL, Hayes JA (1975) Cellular proliferation induced in the lung by cadmium aerosol. Am Rev Respir Dis 112(2):173–179Google Scholar
  27. Pearson CA, Lamar PC, Prozialeck WC (2003) Effects of cadmium on E-cadherin and VE-cadherin in mouse lung. Life Sci 72(11):1303–1320CrossRefGoogle Scholar
  28. Rokadia H, Agarwal S (2013) Serum heavy metals and obstructive lung disease: results from the National Health and Nutrition Examination Survey. Chest 143(2):388–397CrossRefGoogle Scholar
  29. Rousseau MC, Parent ME, Nadon L, Latrellie B, Siemiatycki J (2007) Occupational exposure to lead compounds and risk of cancer among men: a population-based case-control study. Am J Epidemiol 166(9):1005–1014CrossRefGoogle Scholar
  30. Schutz A, Bergdahl IA, Ekholm A, Skerfving S (1996) Measurement by ICP-MS of lead in plasma and whole blood of lead workers and controls. Occup Environ Med 53(11):736–740CrossRefGoogle Scholar
  31. Sharifian SA, Loukzadeh Z, Shojaoddiny-Ardekani A, Aminian O (2011) Pulmonary adverse effects of welding fume in automobile assembly welders. Acta Med Iran 49(2):98–102Google Scholar
  32. Sharma RP, McKenzie JM, Kjellstrom T (1982) Analysis of submicrogramme levels of cadmium in whole blood, urine and hair by graphite furnace atomic absorption spectroscopy. J Anal Toxicol 6(3):135–138CrossRefGoogle Scholar
  33. Steenland K, Barry V, Anttila A, Sallmen M, McElvenny D, Todd AC, Straif K (2017) A cohort mortality study of lead-exposed workers in the USA, Finland and the UK. Occup Environ Med 74(11):785–791CrossRefGoogle Scholar
  34. t Mannetje A, Brennan P, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Cassidy A, Mates D, Bencko V, Foretova L, Janout V, Fevotte J, Fletcher T, Boffetta P (2012) Welding and lung cancer in Central and Eastern Europe and the United Kingdom. Am J Epidemiol 175(7):706–714CrossRefGoogle Scholar
  35. Teschke K, Morgan MS, Checkoway H, Franklin G, Spinelli JJ, van Belle G, Weiss NS (1997) Surveillance of nasal and bladder cancer to locate sources of exposure to occupational carcinogens. Occup Environ Med 54(6):443–451CrossRefGoogle Scholar
  36. Yang T, Sun CS (2006) Stability of blood lead levels in stored specimens: effects of storage time and temperature. J Med Sci 26(6):211–214Google Scholar
  37. Waisberg M, Joseph P, Hale B, Beyersmann D (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192(2–3):95–117CrossRefGoogle Scholar
  38. Yang CF, Shen HM, Shen Y, Zhuang ZX, Ong CN (1997) Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells). Environ Health Perspect 105(7):712–716CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Occupational Medicine, Faculty of MedicineHacettepe UniversityAnkaraTurkey
  2. 2.The Council of Forensic Medicine, Branch Office of AnkaraAnkaraTurkey
  3. 3.Department of Family MedicineAnkara Occupational Diseases HospitalAnkaraTurkey
  4. 4.Department of Public Health and Primary Care, College of Medicine, Nursing and Health SciencesNational UniversitySuvaFiji
  5. 5.Department of BiochemistryYildirim Beyazit UniversityAnkaraTurkey
  6. 6.Department of Public Health, Faculty of MedicineYildirim Beyazit UniversityAnkaraTurkey
  7. 7.Department of Medical Biochemistry, Faculty of MedicineBozok UniversityYozgatTurkey
  8. 8.Department of Medical Humanities and Social Medicine, College of MedicineKosin UniversityBusanKorea

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