Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD
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During the past 15 years, an impressive amount of genetic information has become available in the research field of psychiatry, particularly as it relates to attention-deficit/hyperactivity disorder (ADHD). However, the classical clinical approach to ADHD has minimally affected and not significantly been improved by this genetic revolution. It is difficult to predict how long it will take for genetic findings to alter the way clinicians treat patients with ADHD. New medications or treatment protocols may take years to become routine clinical practice. However, when taken together, recent successes in genomics, pharmacogenomics, and genetic epidemiology have the potential (1) to prevent comorbid consequences of ADHD, (2) to individualize therapies for patients with ADHD, and (3) to define new epidemiological policies to aid with the impact of ADHD on society. Here, we present an overview of how genetic research may affect and improve the quality of life of patients with ADHD: as an example, we use the discovery of LPHN3, a new gene in which variants have recently been shown to be associated with ADHD.
KeywordsADHD Complex trait Gene Genetics LPHN3 Latrophilin
The authors declare no competing financial interests. This research was supported by funds of the NHGRI intramural research program, NIH, Bethesda, MD, USA.
- Arcos-Burgos M, Castellanos FX, Konecki D, Lopera F, Pineda D, Palacio JD et al (2004a) Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate. Mol Psychiatry 9(3):252–259CrossRefPubMedGoogle Scholar
- Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D et al. (2010) A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry (in press)Google Scholar
- Banerjee E, Sinha S, Chatterjee A, Gangopadhyay PK, Singh M, Nandagopal K (2006) A family-based study of Indian subjects from Kolkata reveals allelic association of the serotonin transporter intron-2 (STin2) polymorphism and attention-deficit-hyperactivity disorder (ADHD). Am J Med Genet B Neuropsychiatr Genet 141B(4):361–366CrossRefPubMedGoogle Scholar
- Biederman J, Faraone SV, Keenan K, Benjamin J, Krifcher B, Moore C et al (1992) Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples. Arch Gen Psychiatry 49(9):728–738PubMedGoogle Scholar
- Kent L, Green E, Hawi Z, Kirley A, Dudbridge F, Lowe N et al (2005) Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Mol Psychiatry 10(10):939–943CrossRefPubMedGoogle Scholar
- Lee SS, Lahey BB, Waldman I, Van Hulle CA, Rathouz P, Pelham WE et al (2007) Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Am J Med Genet B Neuropsychiatr Genet 144B(3):310–317CrossRefPubMedGoogle Scholar
- Manor I, Tyano S, Mel E, Eisenberg J, Bachner-Melman R, Kotler M et al (2002) Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (TOVA). Mol Psychiatry 7(6):626–632CrossRefPubMedGoogle Scholar
- Ribases M, Ramos-Quiroga JA, Hervas A, Bosch R, Bielsa A, Gastaminza X et al (2009) Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Mol Psychiatry 14(1):71–85CrossRefPubMedGoogle Scholar
- Risch N (1990) Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet Epidemiol 7(1):3–16 (discussion 7–45)Google Scholar
- Thapar A, O’Donovan M, Owen MJ (2005) The genetics of attention deficit hyperactivity disorder. Hum Mol Genet 14 Spec No. 2:R275–R282Google Scholar
- Wong ML, Arcos-Burgos M, Licinio J (2008) Frontiers in psychiatric research. Psychiatr Times 25(7):1–8Google Scholar