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Impact of respiratory gating and ECG gating on 18F-FDG PET/CT for cardiac sarcoidosis

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The aim of this study was to estimate the impact of respiratory and electrocardiogram (ECG)-gated FDG positron emission tomography (PET)/computed tomography (CT) on the diagnosis of cardiac sarcoidosis (CS).

Methods and Results

Imaging from thirty-one patients was acquired on a PET/CT scanner equipped with a respiratory- and ECG-gating system. Non-gated PET images and three kinds of gated PET/CT images were created from identical list-mode clinical PET data: respiratory-gated PET during expiration (EX), ECG-gated PET at end diastole (ED), and ECG-gated PET at end systole (ES). The maximum standardized uptake value (SUVmax) and cardiac metabolic volume (CMV) were measured, and the locations of FDG accumulation were analyzed using a polar map. The mean SUVmax of the subjects was significantly higher after application of either respiratory-gated or ECG-gated reconstruction. Conversely, the mean CMV was significantly lower following the application of respiratory-gated or ECG-gated reconstruction. The segment showing maximum accumulation was shifted to the adjacent segment in 25.8%, 38.7%, and 41.9% of cases in EX, ED, and ES images, respectively.

Conclusion

In FDG PET/CT scanning for the diagnosis of CS, gated scanning is likely to increase quantitative accuracy, but the effect depends on the location and synchronization method.

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Figure 1
Figure 2

Abbreviations

CMV:

Cardiac metabolic volume

CS:

Cardiac sarcoidosis

FDG:

Fluorine-18-fluorodeoxyglucose

PET:

Positron emission tomography

SUVmax:

Maximum standardized uptake value

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Acknowledgements

We thank Edanz (https://jp.edanz.com/ac) for editing a draft of this manuscript.

Disclosures

The authors Kohei Hanaoka PhD, Shota Watanabe PhD, Daisuke Morimoto-Ishikawa MS, Hayato Kaida MD, PhD, Takahiro Yamada PhD, Masakazu Yasuda MD, PhD, Yoshitaka Iwanaga MD, PhD, Gaku Nakazawa MD, PhD, and Kazunari Ishii MD, PhD declare that they have no conflict of interest.

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Authors and Affiliations

  1. Division of Positron Emission Tomography, Institute of Advanced Clinical Medicine, Kindai University Hospital, 377-2 Ohno-Higashi, Osakasayama, Osaka, 589-8511, Japan

    Kohei Hanaoka PhD, Shota Watanabe PhD, Daisuke Morimoto-Ishikawa MS,  MD PhD, Takahiro Yamada PhD & Kazunari Ishii MD, PhD

  2. Department of Radiology, Kindai University Faculty of Medicine, Osakasayama, Japan

    MD PhD & Kazunari Ishii MD, PhD

  3. Division of Cardiology, Department of Internal Medicine, Kindai University Faculty of Medicine, Osakasayama, Japan

    MD PhD &  MD PhD

  4. Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center, Suita, Japan

    MD PhD

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  1. Kohei Hanaoka PhD
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  2. Shota Watanabe PhD
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  4. Hayato Kaida
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  11. Gaku Nakazawa
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  13. Kazunari Ishii MD, PhD
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Correspondence to Kohei Hanaoka PhD.

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Hanaoka, K., Watanabe, S., Morimoto-Ishikawa, D. et al. Impact of respiratory gating and ECG gating on 18F-FDG PET/CT for cardiac sarcoidosis. J. Nucl. Cardiol. 30, 1879–1885 (2023). https://doi.org/10.1007/s12350-023-03236-0

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  • DOI: https://doi.org/10.1007/s12350-023-03236-0

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