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Cardiac uptake patterns in routine 18F-FDG PET-CT scans: A pictorial review

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Journal of Nuclear Cardiology Aims and scope

Abstract

Broad variability of 18F-Fluoro-2-deoxyglucose (FDG) uptake is noted in myocardium while performing FDG PET-CT scans for viability, infection, or oncologic purposes. While most of the uptakes are considered non-specific, presence of underlying cardiac disease is seldom encountered. With this presentation, our intent is to pictorially highlight the variable FDG uptake patterns associated with the normal variations, benign, and malignant disease.

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References

  1. Shao D, Tian R. Glucose transporters in cardiac metabolism and hypertrophy. Compr Physiol 2015;6:331-51.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Inglese E, Leva L, Matheoud R, Sacchetti G, Secco C, Gandolfo P, Brambilla M. Sambuceti G Spatial and temporal heterogeneity of regional myocardial uptake in patients without heart disease under fasting conditions on repeated whole-body 18F-FDG PET/CT. J Nucl Med 2007;48(10):1662-9.

    Article  PubMed  Google Scholar 

  3. Gropler RJ, Siegel BA, Lee KJ, Moerlein SM, Perry DJ, Bergmann SR, Geltman EM. Nonuniformity in myocardial accumulation of fluorine-18-fluorodeoxyglucose in normal fasted humans. J Nucl Med 1990;31(11):1749-56.

    CAS  PubMed  Google Scholar 

  4. Feygin J, Hu Q, Swingen C, Zhang J. Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy. Am J Physiol Heart Circ Physiol 2008;294(5):H2313-21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Fukuchi K, Ohta H, Matsumura K, Ishida Y. Benign variations and incidental abnormalities of myocardial FDG uptake in the fasting state as encountered during routine oncology positron emission tomography studies. Br J Radiol 2007;80(949):3-11.

    Article  CAS  PubMed  Google Scholar 

  6. Israel O, Weiler-Sagie M, Rispler S, Bar-Shalom R, Frenkel A, Keidar Z, Bar-Shalev A, Strauss HW. PET/CT quantitation of the effect of patient-related factors on cardiac 18F-FDG uptake. J Nucl Med 2007;48(2):234-9.

    CAS  PubMed  Google Scholar 

  7. Zeegers A, van Wilgenburg H, Leeuwin RS. Cardiac effects of benzodiazepine receptor agonists and antagonists in the isolated rat heart: a comparative study. Life Sci 1998;63:1439-56.

    Article  CAS  PubMed  Google Scholar 

  8. Gerard PS, Finestone H, Lazzaro R et al. Intermittent FDG uptake in lipomatous hypertrophy of the interatrial septum on serial PET/CT scans. Clin Nucl Med 2008;33(9): 602-5.

  9. Nadra I, Dawson D, Schmitz SA et al. Lipomatous hypertrophy of the interatrial septum: a commonly misdiagnosed mass often leading to unnecessary cardiac surgery. Heart 2004;90(12):e66.

  10. Reyes CV, Jablokow VR. Lipomatous hypertrophy of the cardiac interatrial septum: A report of 38 cases and review of the literature. Am J Clin Pathol 1979;72:785-8.

    Article  CAS  PubMed  Google Scholar 

  11. Fujii H, Ide M, Yasuda S, et al. Increased FDG uptake in the wall of the right atrium in people who participated in a cancer screening program with whole-body PET. Ann Nucl Med 1999;13:55-9.

    Article  PubMed  Google Scholar 

  12. Wasselius JA, Larsson SA, Jacobsson H. FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients. Mol Imaging Biol 2009;11:455-9.

    Article  PubMed  Google Scholar 

  13. Yamagishi H, Shirai N, Takagi M, Yoshiyama M, AkiokaK, Takeuchi K, et al. Identification of cardiac sarcoidosis with 13N-NH3/18F-FDG PET. J Nucl Med 2003;44:1030-6.

  14. Tezuka Daisuke, Haraguchi Go, Ishihara Takashi, Ohigashi Hirokazu, Inagaki Hiroshi, Suzuki Jun-ichi, Hirao Kenzo, Isobe Mitsuaki. Role of FDG PET-CT in Takayasu arteritis: Sensitive detection of recurrences. JACC Cardiovasc Imaging 2012;5(4):422-9. https://doi.org/10.1016/j.jcmg.2012.01.013.

    Article  PubMed  Google Scholar 

  15. Putnam JB, Sweeny MS, Colon R, Lanza LA, Frazier OH, Cooley DA. Primary cardiac sarcoma. Ann Thorac Surg 1991;51:906-10.

    Article  PubMed  Google Scholar 

  16. Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR. Primary cardiac and pericardial neoplasms: Radiologic-pathologic correlation. RadioGraphics 2000;20(4):1073-1103.

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Authors and Affiliations

  1. Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, USA

    Khushboo Gupta MD, Rahul Jadhav MD, Rameshwar Prasad PhD & Sumeet Virmani MD

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  1. Khushboo Gupta MD
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  2. Rahul Jadhav MD
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  3. Rameshwar Prasad PhD
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  4. Sumeet Virmani MD
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Correspondence to Khushboo Gupta MD.

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Gupta, K., Jadhav, R., Prasad, R. et al. Cardiac uptake patterns in routine 18F-FDG PET-CT scans: A pictorial review. J. Nucl. Cardiol. 27, 1296–1305 (2020). https://doi.org/10.1007/s12350-020-02049-9

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  • DOI: https://doi.org/10.1007/s12350-020-02049-9

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