Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy



To define the diagnostic power of absolute myocardial blood flow (MBF) evaluation on dynamic CZT imaging in intermediate risk patients in comparison with invasive coronary angiography (ICA) and fractional flow reserve (FFR).


Twenty-three stable CAD patients underwent one-day dynamic rest-stress 99mTc-Sestamibi myocardial perfusion imaging by CZT camera. Stress and rest MBF values were calculated semi-automatically using a net retention model by Leppo. Coronary flow reserve (CFR) and flow difference (FD) [MBF stress − MBF rest] were also estimated. A total of 28 vessels were functionally quantified with FFR: 19 (68%) vessels with a stenosis ≥ 70% and 9 (32%) with < 70% stenotic lesions.


The mean global MBFs at rest and during stress were 0.36 (IQR 0.33-0.54) mL/min/g and 0.67 (IQR 0.55-0.81) mL/min/g, respectively, with an average CFR of 1.80 (IQR 1.35-2.24). Moderate correlations between stenosis severity and FFR (r = 0.45; P = .01), stress MBF (r = −0.46; P = .01) and FD (r = −0.37; P = .04) were detected. FFR abnormalities were best predicted by absolute stress MBF, CFR and FD with values of ≤ 0.54 mL/min/g (sensitivity 61.5%; specificity 93.3%), ≤ 1.48 (sensitivity 69.2%; specificity 93.3%) and ≤ 0.18 mL/min/g (sensitivity 69.2%; specificity 100%), respectively.


The values of stress MBF, CFR and FD obtained through dynamic CZT acquisitions compare well with invasive FFR. The clinical use of dynamic acquisition of myocardial perfusion imaging by CZT may help cardiologist in the detection of hemodynamically significant CAD.

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Figure  1
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Coronary artery disease


Coronary flow reserve




Flow difference


Fractional flow reserve


Invasive coronary angiography


Myocardial blood flow


Myocardial perfusion imaging


Single-photon emission computerized


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Konstantin V. Zavadovsky, Andrew V. Mochula, Alla A. Boshchenko, Alexander V. Vrublevsky, Andrew E. Baev, Alexander L. Krylov, Marina O. Gulya, Evgeny A. Nesterov, Riccardo Liga and Alessia Gimelli declare that they have no conflict of interests.

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Correspondence to Konstantin V. Zavadovsky MD.

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Contribution of Evgeniy A. Nesterov from Tomsk Polytechnic University was funded by Tomsk Polytechnic University Competitiveness Enhancement Program Grant (VIU-Laboratory No. 31 YAR-221/2018).

All editorial decisions for this article, including selection of reviewers and the final decision, were made by guest editor Saurabh Malhotra, MD, MPH.

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Zavadovsky, K.V., Mochula, A.V., Boshchenko, A.A. et al. Absolute myocardial blood flows derived by dynamic CZT scan vs invasive fractional flow reserve: Correlation and accuracy. J. Nucl. Cardiol. 28, 249–259 (2021). https://doi.org/10.1007/s12350-019-01678-z

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  • Absolute myocardial blood flow
  • coronary flow reserve
  • CZT camera
  • fractional flow reserve