Agreement between left ventricular ejection fraction assessed in patients with gated IQ-SPECT and conventional imaging

  • Lucia Leva
  • Roberta Matheoud
  • Gianmauro Sacchetti
  • Alessandro Carriero
  • Marco BrambillaEmail author
Original Article



The aim of the study was to assess the agreement between the left ventricular ejection fraction (LVEF) values obtained with IQ-SPECT and those obtained with a conventional gamma camera equipped with low-energy high-resolution (LEHR), considered as the method of reference.


Gated-stress MPI using 99mTc-tetrofosmin was performed in 55 consecutive patients. The patients underwent two sequential acquisitions (Method A and B) performed on Symbia-IQ SPECT with different acquisition times and one (Method C) on a Ecam SPECT equipped with LEHR collimators. The values of the different datasets were compared using the Bland-Altman analysis method: the bias and the limits of agreement (LA) were estimated in a head-to-head comparison of the three protocols.


In the (Method A-Method C) comparison for LVEF, the bias was 3.8% and the LAs ranged from − 9.3% to 16.8%. The agreement was still lower between Method B and C, whilst only slightly improved when Methods A and B were compared.


The wide amplitude in LA intervals of about 30% indicates that IQ and LEHR GSPECT are not interchangeable. The values obtained with IQ-SPECT should only be used with caution when evaluating the functional state of the heart.


CAD gated SPECT instrumentation perfusion agents statistical analysis 



End diastolic volume


End systolic volume


Filtered back projection




Limits of agreement




Left ventricular


Left ventricular ejection fraction


Myocardial perfusion imaging



We would like to thank Clizia Dionisi (MSc) for her valuable contribution in the collection of data.


No potential conflict of interest relevant to this article was reported.

Author Contributions

Study concept and design: M. Brambilla, L. Leva, R. Matheoud. Data acquisition: L. Leva, G. Sacchetti, R. Matheoud. Analysis and interpretation of data: M. Brambilla, L. Leva, R. Matheoud, A. Carriero. Drafting of the manuscript: M. Brambilla, R. Matheoud, L. Leva. Clinical revision of the manuscript for important intellectual content: L. Leva, G. Sacchetti, A. Carriero. Final approval of the manuscript submitted: all authors.

Supplementary material

12350_2018_1457_MOESM1_ESM.pptx (191 kb)
Supplementary material 1 (PPTX 191 kb)


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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Lucia Leva
    • 1
  • Roberta Matheoud
    • 2
  • Gianmauro Sacchetti
    • 1
  • Alessandro Carriero
    • 3
  • Marco Brambilla
    • 2
    Email author
  1. 1.Department of Nuclear MedicineUniversity Hospital ‘Maggiore della Carità’NovaraItaly
  2. 2.Department of Medical PhysicsUniversity Hospital ‘Maggiore della Carità’NovaraItaly
  3. 3.Department of RadiologyUniversity Hospital ‘Maggiore della Carità’NovaraItaly

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