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Noninvasive estimation of quantitative myocardial blood flow with Tc-99m MIBI by a compartment model analysis in rat

  • Atsutaka Okizaki
  • Michihiro Nakayama
  • Kaori Nakajima
  • Osuke Fujimoto
  • Shinobu Oshikiri
  • Miho Koike-Satake
  • Yuto Nakahara
Original Article

Abstract

Background

We aimed to investigate the use of dynamic cardiac planar images to estimate myocardial blood flow (MBF) by a compartment model analysis using time-to-peak (TP) map and compared it by the microsphere technique in rat. Positron emission tomography is considered the gold standard method, but is not available everywhere. By contrast, although myocardial perfusion imaging (MPI) with single-photon tracers is more widely available, it may be difficult to obtain adequate region of interest (ROI) settings. We proposed using the TP map to set the ROI, and hypothesized that this method could facilitate the measurement of absolute MBF by MPI in rat.

Methods

Twenty-one normal rats were studied. Dynamic planar images with Tc-99m MIBI were obtained, and input function and cardiac ROIs were set using the obtained TP map. MBF was estimated by a one-compartment model analysis with the Renkin-Crone model and by the microsphere technique.

Results

The MBFs from these two methods were significantly correlated. A negative proportional bias was observed, but no significant difference was observed between the mean MBFs calculated with each method.

Conclusions

MBF estimation by a compartment model analysis using TP map could facilitate absolute MBF measurement in rats.

Keywords

TP map myocardial blood flow compartment model analysis Tc-99m sestamibi rats 

Abbreviations

CFR

Coronary flow reserve

MBF

Myocardial blood flow

PET

Positron emission tomography

MPI

Myocardial perfusion imaging

Tc-99m MIBI

Technetium-99m sestamibi

CZT

Cadmium-zinc-telluride

SPECT

Single-photon emission computed tomography

ROI

Region of interest

TAC

Time-activity curve

TP

Time-to-peak

Notes

Acknowledgments

We thank Hiroshi Kato and Kentaro Suzuki for animal surgery support, and Professor Koji Takahashi for allowing the use of all equipment.

Disclosures

O. Fujimoto, S. Oshikiri, M. Koike-Satake, and Y. Nakahara are employees of FujiFilm RI Pharma. No other potential conflict of interest relevant to this article was reported.

Author Contributions

AO wrote the main manuscript. AO and OF designed the study, and OF, SO, MK, and YN performed data acquisition and analysis, technical support. MN and KN performed statistical analysis.

Supplementary material

12350_2018_1274_MOESM1_ESM.pptx (276 kb)
Supplementary material 1 (PPTX 275 kb)

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Copyright information

© American Society of Nuclear Cardiology 2018

Authors and Affiliations

  • Atsutaka Okizaki
    • 1
  • Michihiro Nakayama
    • 1
  • Kaori Nakajima
    • 1
  • Osuke Fujimoto
    • 2
  • Shinobu Oshikiri
    • 2
  • Miho Koike-Satake
    • 2
  • Yuto Nakahara
    • 2
  1. 1.Department of RadiologyAsahikawa Medical UniversityAsahikawaJapan
  2. 2.FujiFilm RI Pharma Co., LtdTokyoJapan

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