Nuclear cardiology in the literature: A selection of recent, original research papers
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Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality
Brett W. Sperry, Michael N. Vranian, Albree Tower-Rader, Rory Hachamovitch, Mazen Hanna, Richard Brunken, Dermot Phelan, Manuel D. Cerqueira and Wael A. Jaber
J Am Coll Cardiol Imaging 2018;11:234-42
Context: Technetium 99 m-pyrophosphate (Tc-PYP) scintigraphy is increasingly being used as the diagnostic standard in cardiac ATTR amyloidosis. Regional variation in myocardial Tc-PYP has been reported. Longitudinal strain (LS) echocardiography has shown an apical sparing distribution of strain abnormality in cardiac amyloidosis.
Methods and Results:To investigate the association between regional uptake of Tc-PYP in transthyretin cardiac amyloidosis (ATTR) and mortality, the authors performed a retrospective analysis of 54 patients with ATTR (age 78 ± 9 years, 76% male and 31% with hereditary ATTR). All patients had undergone planar and attenuation-corrected...