Journal of Nuclear Cardiology

, Volume 25, Issue 2, pp 461–470 | Cite as

Myocardial 123I-metaiodobenzylguanidine imaging in hypertension and left ventricular hypertrophy

  • Riccardo Liga
  • Alessia Gimelli
  • Paolo Marzullo
  • Giuseppe Ambrosio
  • Matteo Cameli
  • Elisabetta Cerbai
  • Stefano Coiro
  • Michele Emdin
  • Rossella Marcucci
  • Doralisa Morrone
  • Alberto Palazzuoli
  • Anna Sonia Petronio
  • Ketty Savino
  • Luigi Padeletti
  • Roberto Pedrinelli
  • On Behalf of Società Italiana di Cardiologia, Sezione Regionale Tosco-Umbra
Review Article


Sympathetic nervous system plays a pivotal role in essential hypertension and in the development of left ventricular hypertrophy. Moreover, cardiac sympathetic dys-regulation has been demonstrated as a key con-causal factor in the genesis and progression of pathologic conditions such as congestive heart failure and ischemic heart disease to which hypertension predisposes as a risk factor. However, despite its fundamental role in cardiac pathophysiology, the evaluation of cardiac sympathetic nervous system has never gained a wide clinical application, remaining mostly a research tool. In this context, nuclear imaging techniques are the only modalities to allow the direct evaluation of cardiac sympathetic nervous integrity, giving the chance to obtain objective measures of the sympathetic tone. This review, while summarizing the general profile of currently available tests for autonomic evaluation, focuses on 123I-metaiodobenzylguanidine nuclear imaging as a preferential tool to assess cardiac sympathetic status. Specifically, the review discusses the available evidence on cardiac 123I-metaiodobenzylguanidine scintigraphy in arterial hypertension and left ventricular hypertrophy and its diagnostic and prognostic potential in congestive heart failure and ischemic heart disease.


123I-metaiodobenzylguanidine Sympathetic nervous system Arterial hypertension Left ventricular hypertrophy Congestive heart failure 



Autonomic nervous system


Aortic stenosis


Baroreflex sensitivity


Congestive heart failure




Essential hypertension


Left ventricular hypertrophy




Sympathetic nervous system


Single-photon emission computed tomography



All authors have nothing to disclose.

Supplementary material

12350_2017_1029_MOESM1_ESM.ppt (1.2 mb)
Supplementary material 1 (PPT 1196 kb)


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Copyright information

© American Society of Nuclear Cardiology 2017

Authors and Affiliations

  • Riccardo Liga
    • 1
  • Alessia Gimelli
    • 2
  • Paolo Marzullo
    • 2
    • 3
  • Giuseppe Ambrosio
    • 4
  • Matteo Cameli
    • 5
  • Elisabetta Cerbai
    • 6
  • Stefano Coiro
    • 4
  • Michele Emdin
    • 2
  • Rossella Marcucci
    • 7
  • Doralisa Morrone
    • 1
  • Alberto Palazzuoli
    • 8
  • Anna Sonia Petronio
    • 1
  • Ketty Savino
    • 4
  • Luigi Padeletti
    • 7
    • 9
  • Roberto Pedrinelli
    • 1
  • On Behalf of Società Italiana di Cardiologia, Sezione Regionale Tosco-Umbra
  1. 1.Dipartimento di Patologia Chirurgica, Molecolare e dell’Area CriticaUniversità di Pisa MedicaPisaItaly
  2. 2.Fondazione Toscana G. MonasterioPisaItaly
  3. 3.Istituto di Fisiologia ClinicaCNRPisaItaly
  4. 4.Dipartimento di Medicina, Sezione di Cardiologia e Fisiopatologia CardiovascolareUniversità di PerugiaPerugiaItaly
  5. 5.Dipartimento di Biotecnologie Mediche, Cardiologia UniversitariaUniversità di SienaSienaItaly
  6. 6.Dipartimento di Neuroscienze, Area del Farmaco e Salute del Bambino (NEUROFARBA)Università di FirenzeFlorenceItaly
  7. 7.Dipartimento di Medicina Sperimentale e ClinicaUniversità di FirenzeFlorenceItaly
  8. 8.Dipartimento di Medicina InternaUniversità di SienaSienaItaly
  9. 9.IRCCS MultimedicaMilanItaly

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