Journal of Nuclear Cardiology

, Volume 25, Issue 2, pp 532–535 | Cite as

Assessment of asynchrony by gated myocardial perfusion imaging improves patient management: Pro

  • Mario Petretta
  • Andrea Petretta
  • Alberto Cuocolo
Debate Article

The diagnostic and prognostic utility of gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in patients with suspected or known coronary artery disease (CAD) is well established. In addition to myocardial perfusion and left ventricular (LV) function, gated SPECT allows the assessment of mechanical asynchrony that may occur during contraction or relaxation. The normal LV contracts in a coordinated behavior and most of the myocardial segments have nearly the same phase, with little more than 40 ms variation at the onset of electrical activation. Mechanical asynchrony refers to the abnormal prolongation of the timing of contraction or relaxation between the atrium and ventricle, between the right ventricle (RV) and LV or between different LV segments. LV asynchrony is often observed in patients with heart failure (HF), due to electrical conduction delay in some regions of the LV, which in turn leads to uncoordinated contraction and reduced cardiac...



The authors have indicated that they have no financial conflict of interest.


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Copyright information

© American Society of Nuclear Cardiology 2017

Authors and Affiliations

  • Mario Petretta
    • 1
  • Andrea Petretta
    • 2
  • Alberto Cuocolo
    • 3
  1. 1.Department of Translational Medical SciencesUniversity Federico IINaplesItaly
  2. 2.Department of ArrhythmologyMaria Cecilia Hospital, GVM Care and ResearchCotignolaItaly
  3. 3.Department of Advanced Biomedical SciencesUniversity Federico IINaplesItaly

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