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[18F]-NaF PET/CT imaging in cardiac amyloidosis

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Journal of Nuclear Cardiology Aims and scope

Abstract

Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.

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Authors and Affiliations

  1. UPEC, AP-HP Henri-Mondor Teaching Hospital, 94000, Créteil, France

    Axel Van Der Gucht MD, Arnault Galat MD, Jean Rosso MD, Aziz Guellich PhD, Diane Bodez MD, Violaine Plante-Bordeneuve MD, PhD, Luc Hittinger MD, PhD, Jean-Luc Dubois-Randé MD, PhD, Eva Evangelista MD, Myriam Sasanelli MD, Julia Chalaye MD, Michel Meignan MD, PhD, Emmanuel Itti MD, PhD & Thibaud Damy MD, PhD

  2. Mondor Amyloidosis Network, 94000, Créteil, France

    Axel Van Der Gucht MD, Arnault Galat MD, Jean Rosso MD, Aziz Guellich PhD, Diane Bodez MD, Violaine Plante-Bordeneuve MD, PhD, Luc Hittinger MD, PhD, Jean-Luc Dubois-Randé MD, PhD, Michel Meignan MD, PhD, Emmanuel Itti MD, PhD & Thibaud Damy MD, PhD

  3. DHU ATVB, 94000, Créteil, France

    Axel Van Der Gucht MD, Arnault Galat MD, Jean Rosso MD, Aziz Guellich PhD, Diane Bodez MD, Violaine Plante-Bordeneuve MD, PhD, Luc Hittinger MD, PhD, Jean-Luc Dubois-Randé MD, PhD, Eva Evangelista MD, Myriam Sasanelli MD, Julia Chalaye MD, Michel Meignan MD, PhD, Emmanuel Itti MD, PhD & Thibaud Damy MD, PhD

  4. Department of Nuclear Medicine, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, 94010, Créteil, France

    Axel Van Der Gucht MD, Jean Rosso MD, Eva Evangelista MD, Myriam Sasanelli MD, Julia Chalaye MD, Michel Meignan MD, PhD & Emmanuel Itti MD, PhD

  5. INSERM U955, GRC Réseau Amylose Mondor, 94000, Créteil, France

    Axel Van Der Gucht MD, Arnault Galat MD, Aziz Guellich PhD, Diane Bodez MD, Violaine Plante-Bordeneuve MD, PhD, Luc Hittinger MD, PhD, Jean-Luc Dubois-Randé MD, PhD, Emmanuel Itti MD, PhD & Thibaud Damy MD, PhD

  6. Department of Cardiology, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, 94010, Créteil, France

    Arnault Galat MD, Aziz Guellich PhD, Diane Bodez MD, Luc Hittinger MD, PhD, Jean-Luc Dubois-Randé MD, PhD & Thibaud Damy MD, PhD

  7. Cardiovascular Magnetic Resonance Department, Institut Cardiovasculaire Paris Sud, Hôpital Privé Jacques Cartier, Ramsay-Générale de Santé, 91300, Massy, France

    Jérôme Garot MD, PhD

  8. Department of Neurology, AP-HP, Henri-Mondor Teaching Hospital, 51 Ave. du Mal de Lattre de Tassigny, 94010, Créteil, France

    Violaine Plante-Bordeneuve MD, PhD

Authors
  1. Axel Van Der Gucht MD
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  2. Arnault Galat MD
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  3. Jean Rosso MD
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  4. Aziz Guellich PhD
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  5. Jérôme Garot MD, PhD
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  6. Diane Bodez MD
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  7. Violaine Plante-Bordeneuve MD, PhD
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  8. Luc Hittinger MD, PhD
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  9. Jean-Luc Dubois-Randé MD, PhD
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  10. Eva Evangelista MD
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  11. Myriam Sasanelli MD
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  12. Julia Chalaye MD
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  13. Michel Meignan MD, PhD
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  14. Emmanuel Itti MD, PhD
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  15. Thibaud Damy MD, PhD
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Corresponding author

Correspondence to Axel Van Der Gucht MD.

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Van Der Gucht, A., Galat, A., Rosso, J. et al. [18F]-NaF PET/CT imaging in cardiac amyloidosis. J. Nucl. Cardiol. 23, 846–849 (2016). https://doi.org/10.1007/s12350-015-0287-0

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  • DOI: https://doi.org/10.1007/s12350-015-0287-0

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