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Evaluation of attenuation correction in cardiac PET using PET/MR

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Journal of Nuclear Cardiology Aims and scope



Simultaneous acquisition Positron emission tomography/magnetic resonance (PET/MR) is a new technology that has potential as a tool both in research and clinical diagnosis. However, cardiac PET acquisition has not yet been validated using MR imaging for attenuation correction (AC). The goal of this study is to evaluate the feasibility of PET imaging using a standard 2-point Dixon volume interpolated breathhold examination (VIBE) MR sequence for AC.

Methods and Results

Evaluation was performed in both phantom and patient data. A chest phantom containing heart, lungs, and a lesion insert was scanned by both PET/MR and PET/CT. In addition, 30 patients underwent whole-body 18F-fluorodeoxyglucose PET/CT followed by simultaneous cardiac PET/MR. Phantom study showed 3% reduction of activity values in the myocardium due to the non-inclusion of the phased array coil in the AC. In patient scans, average standardized uptake values (SUVs) obtained by PET/CT and PET/MR showed no significant difference (n = 30, 4.6 ± 3.5 vs 4.7 ± 2.8, P = 0.47). There was excellent per patient correlation between the values acquired by PET/CT and PET/MR (R 2 = 0.97).


Myocardial SUVs PET imaging using MR for AC shows excellent correlation with myocardial SUVs obtained by standard PET/CT imaging. The 2-point Dixon VIBE MR technique can be used for AC in simultaneous PET/MR data acquisition.

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Positron emission tomography/magnetic resonance


Positron emission tomography/computed tomography


Attenuation correction


Standardized uptake values


Late gadolinium enhancement




Magnetic resonance attenuation correction


Computed tomography attenuation correction


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Research reported in this publication was supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH.

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Correspondence to Jeffrey M. C. Lau MD, PhD.

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A related editorial is forthcoming.

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Lau, J.M.C., Laforest, R., Sotoudeh, H. et al. Evaluation of attenuation correction in cardiac PET using PET/MR. J. Nucl. Cardiol. 24, 839–846 (2017).

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