Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera
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New multipinhole cadmium-zinc-telluride (CZT) cameras allow for faster imaging and lower radiation doses for single photon emission computed tomography (SPECT) studies, but assessment of prognostic ability is necessary.
Methods and Results
We collected data from all myocardial SPECT perfusion studies performed over 15 months at our institution, using either a CZT or conventional Anger camera. A Cox proportional hazards model was used to assess the relationship between camera type, imaging results, and either death or myocardial infarction (MI). Clinical variables including age, sex, body mass index (BMI), and historical risk factors were used for population description and model adjustments. We had 2,088 patients with a total of 69 deaths and 65 MIs (122 events altogether). A 3% increase in DDB (difference defect burden) represented a 12% increase in the risk of death or MI, whereas a 3% increase in rest defect burden or stress defect burden represented an 8% increase; these risks were the same for both cameras (P > .24, interaction tests).
The CZT camera has similar prognostic values for death and MI to conventional Anger cameras. This suggests that it may successfully be used to decrease patient dose.
KeywordsEvidence-based medicine SPECT solid-state camera CZT outcomes
Coronary artery disease
Summed stress score
Summed difference score
Summed rest score
Stress defect burden
Rest defect burden
Difference defect burden
Jorge Oldan, Paul Hofmann, Linda K. Shaw, Matthew Phelan, and Salvador Borges-Neto have no conflicts of interest. Jorge Oldan and Salvador Borges-Neto are affiliated with Duke University Medical Center. Paul Hofmann, Linda K. Shaw, and Matthew Phelan are associated with the Duke Clinical Research Institute.
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