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The importance of a correct positioning of the heart using IQ-SPECT system with multifocal collimators in myocardial perfusion imaging: A phantom study

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

We have recently validated a quarter-time protocol in Myocardial Perfusion Imaging named IQ-SPECT, whose basic principle is to implement a multifocal collimator; However, in clinical practice, it may sometimes be difficult to center the heart in the region of highest magnification of the multifocal collimators (the so-called sweet spot). We therefore aimed to evaluate whether a heart mispositioning may affect results in MPI.

Methods

We simulated a rest study with an anthropomorphic phantom with an in vivo distribution of 400 MBq [99mTc]tetrofosmin, with and without a transmural defect (TD). For each set of images, we performed 5 acquisitions, one with a correct centering and with other 4 degrees of mispositioning. Raw data and reconstructed images were evaluated qualitatively and quantitatively, including no corrections, correction for attenuation, for scatter or for both. We assessed polar plot uniformity, LV wall thickness, and TD and cavity contrast.

Results

Images obtained either with a correct heart centering or with mild misposition showed no differences, both qualitatively and quantitatively. Those obtained with major mispositioning differed in uniformity and TD contrast depending on correction parameters.

Conclusion

This is the first study investigating how a heart mispositioning can affect diagnostic accuracy with IQ-SPECT system. Mild-to-moderate mispositioning (≤2.5 cm) is unlikely to significantly affect results.

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Ethical Standard

The research reported in the paper was undertaken in compliance with the Helsinki declaration and the International Principles governing research on animals.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Fondazione Poliambulanza, Brescia, Italy

    Federico Caobelli MD, FEBNM, Alberto Soffientini PhD, Claudio Pizzocaro MD, Giordano Savelli MD & Ugo Paolo Guerra MD

  2. Klinik für Nuklearmedizin, Medizinische Hochschule Hannover, Carl Neuberg Straße, 1, 30625, Hannover, Germany

    Federico Caobelli MD, FEBNM, James Thomas Thackeray PhD & Frank Michael Bengel MD, FAHA

  3. Department of Medical Physics, Fondazione Poliambulanza, Brescia, Italy

    Stefano Ren Kaiser PhD, Matteo Chieregato PhD & Marco Galelli PhD

  4. Department of Nuclear Medicine, S. Maugeri Foundation, IRCCS, Scientific Institute of Veruno, Veruno, NO, Italy

    Orazio Zoccarato PhD

Authors
  1. Federico Caobelli MD, FEBNM
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  2. Stefano Ren Kaiser PhD
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  3. James Thomas Thackeray PhD
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  4. Frank Michael Bengel MD, FAHA
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  5. Matteo Chieregato PhD
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  6. Alberto Soffientini PhD
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  7. Claudio Pizzocaro MD
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  8. Giordano Savelli MD
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  9. Ugo Paolo Guerra MD
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  10. Marco Galelli PhD
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  11. Orazio Zoccarato PhD
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Corresponding author

Correspondence to Federico Caobelli MD, FEBNM.

Additional information

The authors disclosure of any personal or financial support or author involvement with organization(s) with financial interest in the subject matter—or any actual or potential conflict of interest.

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Caobelli, F., Ren Kaiser, S., Thackeray, J.T. et al. The importance of a correct positioning of the heart using IQ-SPECT system with multifocal collimators in myocardial perfusion imaging: A phantom study. J. Nucl. Cardiol. 22, 57–65 (2015). https://doi.org/10.1007/s12350-014-9994-1

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  • DOI: https://doi.org/10.1007/s12350-014-9994-1

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