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Linear relation between spirometric volume and the motion of cardiac structures: MRI and clinical PET study

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

In cardiac PET, CT, and MRI respiration is major reason for impaired image quality of small targets such as coronary arteries. Strong correlations between heart motion and respiratory signals have been detected but quantitative relation between signals and motion of cardiac structures in MRI or PET is not reported .

Methods

Relation between spirometric lung volume or pressure belt signal and motion of coronary vessels in MRI was studied on nine healthy volunteers. Spirometry was further applied to 18F-FDG cardiac PET study to determine quantitative relation between volume change and motion of center of myocardium activity (CMA) on nine CAD patients.

Results

Correlation coefficients (CC) between vessel motions and volume or pressure changes were 0.90-0.92 or 0.86-0.84, respectively. The linear equations based on volume or pressure changes derived 2.0-2.6 or 2.9-3.3 mm mean estimation error for vessel motions. In PET CC value of 0.93 was determined between volume changes and CMA motions. The linear equation based on volume change derived maximum estimation error of 2.5 mm for CMA motion.

Conclusion

The spirometric volume change linearly estimates motion of myocardium in PET with good accuracy and have potential to guide selection of optimal number of respiratory gates in cardiac PET.

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Acknowledgments

The authors thank GE Healthcare for providing RGT software in our use. This study was conducted within the “Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research” supported by the Academy of Finland, University of Turku, Turku University Hospital and Åbo Academy.

Disclosures

The authors do not have any disclosures or conflict of interest and we transfer copyright to American Society of Nuclear Cardiology, Journal of Nuclear Cardiology.

Author information

Authors and Affiliations

  1. Turku PET Centre, University of Turku and Turku University Hospital, PO BOX 52, 20521, Turku, Finland

    Tommi Kokki MD, MSc, Riku Klén PhD, Tommi Noponen DSc, Jussi Pärkkä MD, Virva Saunavaara PhD, Erika Hoppela MD, Mika Teräs PhD & Juhani Knuuti MD, PhD

  2. Department of Clinical Physiology and Radioisotope Imaging, Turku University Hospital, 20521, Turku, Finland

    Tommi Kokki MD, MSc & Jussi Pärkkä MD

  3. Department of Mathematics and Statistics, University of Turku, 20014, Turku, Finland

    Riku Klén PhD

Authors
  1. Tommi Kokki MD, MSc
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  2. Riku Klén PhD
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  3. Tommi Noponen DSc
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  4. Jussi Pärkkä MD
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  5. Virva Saunavaara PhD
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  6. Erika Hoppela MD
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  7. Mika Teräs PhD
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  8. Juhani Knuuti MD, PhD
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Corresponding author

Correspondence to Tommi Kokki MD, MSc.

Additional information

See related editorial, doi:10.1007/s12350-015-0094-7.

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Kokki, T., Klén, R., Noponen, T. et al. Linear relation between spirometric volume and the motion of cardiac structures: MRI and clinical PET study. J. Nucl. Cardiol. 23, 475–485 (2016). https://doi.org/10.1007/s12350-014-0057-4

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  • DOI: https://doi.org/10.1007/s12350-014-0057-4

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