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Impact of age on myocardial uptake of 123I-mIBG in older adult subjects without coronary heart disease

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The purpose of this study was to examine the relationship between myocardial uptake of 123I-mIBG and age in older normal adult subjects.

Methods

94 subjects (age 29-82, mean 58.5) without coronary heart disease were studied. All subjects underwent early and delayed planar and 4-hour SPECT 123I-mIBG imaging. 123I-mIBG uptake was quantified as heart/mediastinum ratio on planar images (H/M p) and on SPECT images (H/M s) reconstructed by filtered backprojection, ordered subsets-expectation maximization (OSEM), and OSEM with compensation for collimator septal penetration (DSP). Relationships between age and 123I-mIBG uptake were examined by correlation analysis, t-tests, and analysis of variance.

Results

There was no significant correlation between age and H/M p, reflecting comparable increases in activity in the two regions of interest with age. Results on SPECT analyses were comparable, with no significant correlation between age and H/M s. Using DSP, 123I-mIBG H/M s was significantly higher in subjects ≥70 of age compared with younger subjects.

Conclusions

Both cardiac and background uptake of 123I-mIBG increase with age in older subjects without coronary heart disease, resulting in stability of H/M results (planar and SPECT). This study suggests that prognostic analyses of quantitative 123I-mIBG uptake in patients with heart disease do not require adjustment for patient age.

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Acknowledgments

This study was supported in part by GE Healthcare. Dr Jacobson is an employee of GE Healthcare and owns shares in the General Electric Company. Dr Chen, Dr Garcia, and Mr Folks receive royalties from the sale of the Emory Cardiac Toolbox. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict of interest practice.

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Authors and Affiliations

  1. Medical Diagnostics, GE Healthcare, 101 Carnegie Center, Princeton, NJ, 08540, USA

    Arnold F. Jacobson MD, PhD

  2. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA

    Ji Chen PhD, Liudmilla Verdes MD, Russell D. Folks BS, Daya N. Manatunga MS & Ernest V. Garcia PhD

Authors
  1. Arnold F. Jacobson MD, PhD
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  2. Ji Chen PhD
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  3. Liudmilla Verdes MD
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  4. Russell D. Folks BS
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  5. Daya N. Manatunga MS
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  6. Ernest V. Garcia PhD
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Corresponding author

Correspondence to Arnold F. Jacobson MD, PhD.

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Jacobson, A.F., Chen, J., Verdes, L. et al. Impact of age on myocardial uptake of 123I-mIBG in older adult subjects without coronary heart disease. J. Nucl. Cardiol. 20, 406–414 (2013). https://doi.org/10.1007/s12350-013-9701-7

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  • DOI: https://doi.org/10.1007/s12350-013-9701-7

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