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Relation of 99mTc-sestamibi washout with myocardial properties in patients with hypertrophic cardiomyopathy

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

We sought to determine the relationship between 99mTc-sestamibi washout and myocardial properties in hypertrophic cardiomyopathy (HCM) patients.

Methods and Results

Twenty-four HCM patients underwent biventricular cardiac catheterization, with a micromanometer-tipped catheter, both at rest and during atrial pacing, echocardiography and myocardial 99mTc-sestamibi scintigraphy at rest. The 99mTc-sestamibi washout rate (WR) was calculated using initial and delayed planar images. The HCM patients were divided into two groups as follows: Group A consisted of 13 patients showing 99mTc-sestamibi WR < 22.5%; group B of 11 patients showing 99mTc-sestamibi WR ≥ 22.5%. Significant correlations were observed between 99mTc-sestamibi WR and percentage changes in pressure half-time (T 1/2), as well as those in the maximum first derivative LV pressure (LV dP/dt max) (r = .43, P = .033; r = −.63, P = .001). The percentage changes in LV dP/dt max and those in T 1/2 were significantly more reduced in group B than in group A (P < .05). The biphasic force-frequency relation was more frequently observed in group B than in group A (82% vs. 18%).

Conclusion

Increased 99mTc-sestamibi washout is associated with an impaired contractile reserve and prolonged relaxation, suggesting that myocardial 99mTc-sestamibi scintigraphy may be useful in noninvasively detecting the early impairment of myocardial function in HCM patients.

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Authors and Affiliations

  1. Department of Cardiology, Kami-iida Dai-ichi General Hospital, 2-70 Kami-iida Kita-machi, Kita-ku, Nagoya, 462-0802, Japan

    Satoshi Isobe MD, PhD

  2. Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Satoshi Isobe MD, PhD, Satoru Ohshima MD, PhD, Kazumasa Unno MD, Akihiro Hirashiki MD, PhD & Toyoaki Murohara MD, PhD

  3. Department of Internal Medicine, Fujita Health University Banbuntane Hotokukai Hospital, Nagoya, Japan

    Hideo Izawa MD, PhD

  4. Department of Radiological Technology, Nagoya University School of Health Sciences, Nagoya, Japan

    Katsuhiko Kato MD, PhD

  5. Department of Medical Technology, Nagoya University School of Health Sciences, Nagoya, Japan

    Akiko Noda PhD

Authors
  1. Satoshi Isobe MD, PhD
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  2. Satoru Ohshima MD, PhD
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  3. Kazumasa Unno MD
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  4. Hideo Izawa MD, PhD
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  5. Katsuhiko Kato MD, PhD
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  6. Akiko Noda PhD
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  7. Akihiro Hirashiki MD, PhD
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  8. Toyoaki Murohara MD, PhD
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Correspondence to Satoshi Isobe MD, PhD.

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Isobe, S., Ohshima, S., Unno, K. et al. Relation of 99mTc-sestamibi washout with myocardial properties in patients with hypertrophic cardiomyopathy. J. Nucl. Cardiol. 17, 1082–1090 (2010). https://doi.org/10.1007/s12350-010-9266-7

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  • DOI: https://doi.org/10.1007/s12350-010-9266-7

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