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Effects of probiotic ultra-filtered feta cheese and raw chicory root extract on lipid profile in healthy adult volunteers: a triple-blinded randomized controlled trial

  • Shayan Mohammad Moradi
  • Aida Javidan
  • Hamidreza Naji Isfahani
Original Article

Abstract

The role of probiotics and prebiotics as cholesterol reductive agents has drawn a great deal of attention. However, there have been few studies, investigating the effect of prebiotics and probiotics together on lipid profile. The purpose of study was to evaluate the effect of probiotic cheese (PCh) and chicory root extract consumption on lipid profile in a large sample. 180 subjects aged 18–65, with <6 mmol/l total cholesterol participated in the 7-week trial. Subjects randomly assigned into three 60-person groups. E1 consumed 30 g of PCh plus chicory root extract (daily), E2 consumed 30 g of PCh (daily) along with a control group. Probiotics strains in products were Lactobacillus acidophilus LA5 and Bifidobacterium lactis BB12. Anthropometric measurements and blood sampling were conducted at the baseline and end of trial. There was a significant reduction within both intervention groups throughout the study: intervention 1, (LDL: −0.79, 95 % CI −0.96, −0.61, P < 0.0001; cholesterol: −1.02, 95 % CI −1.41, −0.63, P < 0.0001; triglyceride: −0.59, 95 % CI −0.67, −0.51, P < 0.0001; HDL: 0.44, 95 % CI, 0.37, 0.51, P < 0.0001); intervention 2 also showed significant improvements in the mentioned factors. Comparing results of both groups with control showed significant improvements in all factors except triglyceride of intervention 2. PCh and chicory extract showed great effects on improvements of lipid profile, thus they can be used for prevention and treatment purposes.

Keywords

Probiotic cheese Chicory Blood lipids Lactobacillus acidophilus LA5 Bifidobacterium lactis BB12 

Abbreviations

SRBIAU

Science and Research Branch of Islamic Azad University

IDIC

Iran Dairy Industry Corporation

Notes

Acknowledgments

We would like to warmly thank all participants for their contribution to the research. We greatly thank head of research and development department of Iran Dairy Industry Corporation for all of his cooperation. Materials were supported by the Iran Dairy Industry Corporation (IDIC-Pegah). The supporters of Iran Dairy Industry Corporation played no role in the design, conduct, analysis and reporting of the study findings. The research was designed and developed by Sh.M.M. The idea of study was initiated by Sh.M.M. He also performed all the statistical analyses and wrote the manuscript and took the responsibility for the final content. The research was conducted by A.J and H.N.I. They also took the responsibility of follow ups and data collections.

Conflict of interest

All authors approved the final manuscript and declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • Shayan Mohammad Moradi
    • 1
  • Aida Javidan
    • 1
  • Hamidreza Naji Isfahani
    • 1
  1. 1.Omega Research Team (ORT)TehranIran

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