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The intestinal permeability syndrome, celiac disease, gluten sensitivity, autistic spectrum, mycotoxins and immunological tolerance

Mediterranean Journal of Nutrition and Metabolism

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Abstract

The onset of several human diseases takes place in an inefficient intestine. We probably should re-evaluate the relationship between food and health. Three million Italians and twenty million Americans suffer from the gluten sensitivity syndrome, similar yet different from celiac disease. Different pathological status arise as a consequence of sensitivity to gluten, depending on the genetic polymorphism of the subjects and the environment in which they live. If we gain more knowledge on interactions between food, eating habits, genomics and the environment, this could mean better prevention and/or treatment. The era of epigenetics has begun, while the dogma of genetic determinism seems to be fading.

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Authors and Affiliations

  1. Italian Association of Toxic Elements Studys, Rome, Italy

    M. Proietti & C. Di Rienzo

  2. Academy of Micronutrition “L. Pauling”, Caserta, Italy

    A. Del Buono

  3. Department of Biochemistry, Biology and Genetics, School of Medicine, Università Politecnica delle Marche, Ancona, Italy

    G. Pagliaro

  4. Università Campus Bio-Medico, Rome, Italy

    R. Del Buono

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  1. M. Proietti
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  2. A. Del Buono
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  5. C. Di Rienzo
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Correspondence to G. Pagliaro.

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Proietti, M., Del Buono, A., Pagliaro, G. et al. The intestinal permeability syndrome, celiac disease, gluten sensitivity, autistic spectrum, mycotoxins and immunological tolerance. Mediterr J Nutr Metab 6, 99–104 (2013). https://doi.org/10.1007/s12349-013-0125-3

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  • DOI: https://doi.org/10.1007/s12349-013-0125-3

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