The intestinal permeability syndrome, celiac disease, gluten sensitivity, autistic spectrum, mycotoxins and immunological tolerance

  • M. Proietti
  • A. Del Buono
  • G. PagliaroEmail author
  • R. Del Buono
  • C. Di Rienzo


The onset of several human diseases takes place in an inefficient intestine. We probably should re-evaluate the relationship between food and health. Three million Italians and twenty million Americans suffer from the gluten sensitivity syndrome, similar yet different from celiac disease. Different pathological status arise as a consequence of sensitivity to gluten, depending on the genetic polymorphism of the subjects and the environment in which they live. If we gain more knowledge on interactions between food, eating habits, genomics and the environment, this could mean better prevention and/or treatment. The era of epigenetics has begun, while the dogma of genetic determinism seems to be fading.


Mycotoxins Immunological tolerance Intestinal permeability syndrome Celiac disease Gluten sensitivity Autistic spectrum 


Conflict of interest



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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  • M. Proietti
    • 1
  • A. Del Buono
    • 2
  • G. Pagliaro
    • 3
    Email author
  • R. Del Buono
    • 4
  • C. Di Rienzo
    • 1
  1. 1.Italian Association of Toxic Elements StudysRomeItaly
  2. 2.Academy of Micronutrition “L. Pauling”CasertaItaly
  3. 3.Department of Biochemistry, Biology and Genetics, School of MedicineUniversità Politecnica delle MarcheAnconaItaly
  4. 4.Università Campus Bio-MedicoRomeItaly

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