Abstract
Studies have provided evidence of the hypoglycemic properties of fiber-containing foods compared to fiber-free foods. In this study, the hypoglycemic properties and beneficial effects of fiber-enriched cake in alloxan-induced diabetic rats were reported. Diabetes was induced by a single intraperitoneal injection of alloxan. Fiber-enriched cake was produced from selected fruits and fed to the treatment group. The rats were monitored daily for food intake, and body weight. Their blood glucose levels were monitored on weekly basis. Treatment lasted for 14 days, after which the rats were sacrificed by cervical dislocation. Blood was collected by cardiac puncture and centrifuged to obtain serum which was analyzed to evaluate serum insulin level. Histological study was carried out on the pancreatic tissues. There was no significant difference in diet intake and body weight among the experimental groups. Feeding on the formulated cake led to 68.75 % reduction of the blood glucose level compared to the diabetic group. Significant increase (p < 0.05) in serum insulin level was observed in the cake-fed group. Feeding on the formulated cake led to restoration of pancreatic β-cells. The fiber-enriched cake had a therapeutic protective effect against diabetes which can serve as a functional food in the treatment and management of the disease.
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Abbreviations
- FER:
-
Food efficiency ratio
References
Tiwari AK, Rao JM (2002) Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects. Curr Sci 83(1):30–38
Maritim AC, Sanders RA, Watkins JB (2003) Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17:24–38
Rameshkumar K, Shah SN, Goswami VM, Bodhankar SL (2004) Efficacy and toxicity of vanadium nicotinate in diabetic rats. Toxicol Int 11:75–80
Kumar GS, Shetty AK, Sambaiah K, Salimath PV (2005) Antidiabetic property of fenugreek seed mucilage and spent turmeric in streptozotocin-induced diabetic rats. Nutr Res 25:1021–1028
Grower JK, Yadav S, Vats V (2002) Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 81:81–100
Nomura AMY, Hankin JH, Henderson BE, Wilkens LR, Murphy SP, Pike MC et al (2007) Dietary fiber and colorectal cancer risk: the multiethnic cohort study. Canc Cause Cont 18:753–764
Slavin JL (2005) Dietary fiber and body weight. Nutrition 21:411–418
Spiller GA (1993) CRC handbook of dietary fiber in human nutrition, 2nd edn. CRC Press, Inc. Boca Raton, Florida
Slavin JL (2008) Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 108:1716–1731
Galisteo M, Duarte J, Zarzuelo A (2008) Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J Nutr Biochem 19:71–84
National Academy of Sciences (2005) Dietary, functional, and total fiber (Chapter 7). In: Dietary reference intakes for energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein, and amino acids. National Academies Press, Washington
Elleuch M, Bedigian D, Roiseux O, Besbes S, Blecker C, Attia H (2010) Dietary fibre and fibre-rich by-products of food processing: characterisation, technological functionality and commercial applications: a review. Food Chem. doi:10.1016/j.foodchem.2010.06.077
AOAC (1997) Official methods of analysis of the association of analytical chemists, 16th edn. Washington
Van-Burden TP, Robinson WC (1981) Formation of complexes between protein and tannin acid. J Agric Food Chem 1:77–82
Obadoni BO, Ochuko PO (2001) Phytochemical studies and comparative efficacy of the crude extracts of some homeostatic plants in Edo and delta states of Nigeria. Global J Pure Appl Sci 8:203–208
Marles RJ, Farnsworth NR (1995) Antidiabetic plants and their active constituents. Phytomedicine 2:137–189
Willis HJ, Thomas W, Eldridge AL, Harkness L, Green H, Slavin JL (2011) Glucose and insulin do not decrease in a dose-dependent manner after increasing doses of mixed fibers that are consumed in muffins for breakfast. Nutr Res 31:42–47
Srinivasan K, Ramarao P (2007) Animal models in type 2 diabetes research: an overview. Indian J Med Res 125:451–472
Ohno T, Kitoh J, Yamashita K, Ichikawa Y, Horio F, Terada M et al (1998) Toxin-induced IDDM (insulin dependent diabetes mellitus) in the musk shrew. Life Sci 63:455–462
Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51:216–226
King NA, Craig SAS, Pepper T, Blundell JE (2005) Evaluation of the independent and combined effects of xylitol and polydextrose consumed as a snack on hunger and energy intake over 10 days. Br J Nutr 93:911–915
Cani PD, Joly E, Horsmans Y, Delzenne NM (2006) Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 60:567–572
Blundell JE, Halford JC (1994) Regulation of nutrient supply. The brain and appetite control. Proceed Nutr Soc 53:407–418
de Graaf C, Blom WA, Smeets PA, Stafleu A, Hendriks HF (2004) Biomarkers of satiation and satiety. Am J Clin Nutr 79:946–961
Marciani L, Gowland PA, Spiller RC, Manoj P, Moore RJ, Young P et al (2000) Gastric response to increased meal viscosity assessed by echo-planar magnetic resonance imaging in humans. J Nutr 130:122–127
Sommerfield AJ, Deary IJ, Frier BM (2004) Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care 27(10):2335–2340
Gray AM, Flatt PR (1998) Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom). J Endocrinol 157:259–266
Moharib SA, El-Batran SA (2008) Hypoglycemic effect of dietary fibre in diabetic rats. Res J Agric & Biol Sci 4(5):455–461
Cheryan M (1980) Phytic acid interactions in food systems. Crit Rev Food Sci Nutr 13(4):297–335
Xi M, Hai C, Tang H, Chen M, Fang K, Liang X (2008) Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res 22:228–237
Liu X, Kim J, Li Y, Li J, Liu F, Chen X (2005) Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. J Nutr 135:165–171
Lee S, Park H, Chuna H, Choa S, Choa S, Lillehoj HS (2006) Dietary phytic acid lowers the blood glucose level in diabetic KK mice. Nutr Res 26:474–479
Yoon JW, Jun HS (2005) Autoimmune destruction of pancreatic beta cells. Am J Ther 12(6):580–591
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Erukainure, O.L., Ebuehi, O.A.T., Adeboyejo, F.O. et al. Anti-diabetic and hypoglycemic properties of fibre-enriched cake in alloxan-induced diabetic rats. Mediterr J Nutr Metab 6, 135–141 (2013). https://doi.org/10.1007/s12349-012-0116-9
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DOI: https://doi.org/10.1007/s12349-012-0116-9