Role of lentils (Lens culinaris L.) in human health and nutrition: a review

  • Mo’ez Al-Islam Ezzat FarisEmail author
  • Hamed Rabah Takruri
  • Ala Yousef Issa


Humans have known lentils (Lens culinaris L.) since the dawn of civilization. The current work is a comprehensive review of lentils composition, nutritional value, and health benefits. The article addresses major proteins identified in lentils and their bioactive peptides, including lectins, defensins, and protease inhibitors. In addition, this review discusses the complex carbohydrate fractions in lentils, particularly the resistant starches, oligosaccharides, and dietary fibers with emphasis on their biomedical properties. Also, the current review discusses minerals and vitamins as well as the non-nutritive bioactive phytochemicals of lentils which add to the promising potential for clinical applications in the management and prophylaxis of several chronic human illnesses. The article finds out that various potential health benefits have been described for lentils such as anticarcinogenic, blood pressure-lowering, hypocholesterolemic and glycemic load-lowering effects. The proposed mechanisms behind each health benefit are discussed.


Lentils (Lens culinaris L.) Functional foods Nutritional value Health Polyphenols Bioactive peptides 



Thanks are due to Dr. Mohamed Labib Salem/Department of Zoology, Tanta University/Egypt for his many helpful suggestions and comments. Thanks are due to Dr Omar Al-Haj at Department of Nutrition and Food Technology/King Saud University, and Mrs. Noor Hamed at Department of Nutrition/Petra University for their assistance in proofreading and editing the manuscript.

Conflict of interest



  1. 1.
    Tharanathan RN, Mahadevamma S (2003) Grain legumes—A boon to human nutrition. Trends Food Sci Technol 14:507–518CrossRefGoogle Scholar
  2. 2.
    Duranti M (2006) Grain legume proteins and nutraceutical properties. Fitoterapia 77:67–82CrossRefGoogle Scholar
  3. 3.
    Campos-Vega R, Loarca-Pina G, Oomah BD (2010) Minor components of pulses and their potential impact on human health. Food Res Int 43:461–482CrossRefGoogle Scholar
  4. 4.
    Roy F, Boye JI, Simpson BK (2010) Bioactive proteins and peptides in pulse crops: pea, chickpea, and lentil. Food Res Int 43:432–442CrossRefGoogle Scholar
  5. 5.
    Rochfort S, Panozzo J (2007) Phytochemicals for health, the role of pulses. J Agric Food Chem 55:7981–7994CrossRefGoogle Scholar
  6. 6.
    Dilis V, Trichopoulou A (2009) Nutritional and health properties of pulses. Mediterr J Nutr Metab 1:149–157CrossRefGoogle Scholar
  7. 7.
    Food and Agriculture Organization (FAO) (1988) Traditional food plants, Food and Nutrition Paper, FAO, pp 150–154Google Scholar
  8. 8.
    FAOSTAT. Food and Agricultural Organization of United Nations: Economic and Social Department: The Statistical Division. Retrievable from (accessed October 2011)
  9. 9.
    Satya S, Kaushik G, Naik SN (2010) Processing of food legumes: a boon to human nutrition. Mediterr J Nutr Metab 3:183–195CrossRefGoogle Scholar
  10. 10.
    Jood S, Bishnoi S, Sharma A (1998) Chemical analysis and physicochemical properties of chickpea and lentil cultivars. Nahrung/Food 42:71–74CrossRefGoogle Scholar
  11. 11.
    Solanki IS, Kapoor AC, Singh U (1999) Nutritional parameters and yield evaluation of newly developed genotypes of lentil (Lens culinaris Medik.). Plant Foods Hum Nutr 54:79–87CrossRefGoogle Scholar
  12. 12.
    United States Department of Agriculture (USDA) (2011) USDA National Nutrient Database for Standard Reference, Release 23. Retrievable from (accessed Jan 2011)
  13. 13.
    Hoover R, Hughes T, Chung HJ, Liu Q (2010) Composition, molecular structure, properties, and modification of pulse starches: a review. Food Res Int 43:399–413CrossRefGoogle Scholar
  14. 14.
    El-Adawy TA, Rahma EH, El-Bedawey AA, El-Beltagy AE (2003) Nutritional potential and functional properties of germinated mung bean, pea and lentil seeds. Plant Foods Hum Nutr 58:1–13CrossRefGoogle Scholar
  15. 15.
    Bamdad F, Goli AH, Kadivar M (2006) Preparation and characterization of proteinous edible film from lentil (Lens culinaris). Food Res Int 39:106–111CrossRefGoogle Scholar
  16. 16.
    Padovani RM, Lima DM, Colugnati FAB, Rodriguez-Amaya DLB (2007) Comparison of proximate, mineral and vitamin composition of common Brazilian and US food. J Food Comp Anal 20:733–738CrossRefGoogle Scholar
  17. 17.
    Bednar GE, Patil AR, Murray SM, Grieshop CM, Merchen NR, Fahey GCJ (2001) Starch and fiber fractions in selected food and feed ingredients affect their small intestinal digestibility and fermentability and their large bowel fermentability in vitro in a canine model. J Nutr 131:276–286Google Scholar
  18. 18.
    Vidal-Valverde C, Frias J, Sierra I, Blazquez IF, Lambein F, Kuo YH (2002) New functional legume foods by germination: effect on the nutritive value of beans, lentils and peas. Eur Food Res Technol 215:472–477CrossRefGoogle Scholar
  19. 19.
    Han IH (2005) Oligosaccharide reduction, protein digestibility improvement, antioxidant activity determination and phenolic compounds identification in legumes. PhD Thesis, Washington State UniversityGoogle Scholar
  20. 20.
    Ryan E, Galvin K, O’Connor TP, Maguire AR, O’Brien NM (2007) Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes. Plant Foods Hum Nutr 62:85–91CrossRefGoogle Scholar
  21. 21.
    Demirbas A (2005) β-Glucan and mineral nutrient contents of cereals grown in Turkey. Food Chem 90:773–777CrossRefGoogle Scholar
  22. 22.
    Umeta M, West CE, Fufa H (2005) Content of Zn, Fe, Ca and their absorption inhibitors in foods commonly consumed in Ethiopia. J Food Comp Anal 18:803–817CrossRefGoogle Scholar
  23. 23.
    Thavarajah D, Thavarajah P, Sarker A, Materne M, Vandemark G, Shrestha R, Idrissi O, Hacikamiloglu O, Bucak B, Vandenberg A (2011) A global survey of effects of genotype and environment on selenium concentration in lentils (Lens culinaris L.): implications for nutritional fortification strategies. Food Chem 125:72–76CrossRefGoogle Scholar
  24. 24.
    Thavarajah D, Ruszkowski Vandenberg A (2008) High potential for selenium biofortification of lentils (Lens culinaris L.). J Agric Food Chem 56:10747–10753CrossRefGoogle Scholar
  25. 25.
    Ryland D, Vaisey-Genser M, Arntfield SD, Malcolmson LJ (2010) Development of a nutritious acceptable snack bar using micronized flaked lentils. Food Res Int 43:642–649CrossRefGoogle Scholar
  26. 26.
    Issa AY, Volate SR, Wargovich MJ (2006) The role of phytochemicals in inhibition of cancer and inflammation: new directions and perspectives. J Food Comp Anal 19:405–419CrossRefGoogle Scholar
  27. 27.
    Xu BJ, Chang SKC (2007) A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents. J Food Sci 0:S1–S8Google Scholar
  28. 28.
    Zia-ur-Rehman Salariya AM (2005) The effects of hydrothermal processing on antinutrients, protein and starch digestibility of food legumes. Int J Food Sci Technol 40:695–700CrossRefGoogle Scholar
  29. 29.
    Oomah BD, Caspar F, Malcolmson LJ, Bellido AS (2011) Phenolics and antioxidant activity of lentil and pea hulls. Food Res Int 44:436–441CrossRefGoogle Scholar
  30. 30.
    Kalogeropoulos N, Chiou A, Ioannou M, Karathanos VT, Hassapidou M, Andrikopoulos NK (2010) Nutritional evaluation and bioactive microconstituents (phytosterols, tocopherols, polyphenols, triterpenic acids) in cooked dry legumes usually consumed in the Mediterranean countries. Food Chem 121:682–690CrossRefGoogle Scholar
  31. 31.
    Amarowicz R, Estrella I, Hernandez T, Robredo S, Troszynska A, Kosinska A, Pegg RB (2010) Free radical-scavenging capacity, antioxidant activity, and phenolic composition of green lentil (Lens culinaris). Food Chem 121:705–711CrossRefGoogle Scholar
  32. 32.
    Amarowicz R, Estrella I, Hernández T, Duenas M, Troszyńska A, Kosińska A, Pegg RB (2009) Antioxidant activity of a red lentil extract and its fractions. Int J Mol Sci 10:5513–5527CrossRefGoogle Scholar
  33. 33.
    Duenas M, Sun B, Hernandiz T, Estrella I, Spranger MI (2003) Proanthocyanidin composition in the seed coat of lentils (Lens culinaris L.). J Agric Food Chem 51:7999–8004CrossRefGoogle Scholar
  34. 34.
    Duenas M, Hernandez T, Estrella I (2002) Phenolic composition of the cotyledon and the seed coat of lentils (Lens culinaris L.). Eur Food Res Tech 215:478–483CrossRefGoogle Scholar
  35. 35.
    United States Department of Agriculture (USDA) (2006) Database for the Flavonoid Content of Selected Foods Release 2.1. Retrieved from (accessed Jan 2011)
  36. 36.
    Duenas M, Hernandez T, Estrella I (2006) Assessment of in vitro antioxidant capacity of the seed coat and the cotyledon of legumes in relation to their phenolic contents. Food Chem 98:95–103CrossRefGoogle Scholar
  37. 37.
    Xu BJ, Yuan SH, Chang SKC (2007) Comparative analyses of phenolic composition, antioxidant capacity, and color of cool season legumes and other selected food legumes. J Food Sci 72:S167–S177CrossRefGoogle Scholar
  38. 38.
    Xu B, Chang SKC (2011) Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the Northern United States. J Agric Food Chem 58:1509–1517CrossRefGoogle Scholar
  39. 39.
    Graf E, Eaton JW (1990) Antioxidant functions of phytic acid. Free Radic Biol Med 8:61–69CrossRefGoogle Scholar
  40. 40.
    Morris ER, Hill AD (1996) Inositol phosphate content of selected dry beans, peas, and lentils, raw and cooked. J Food Comp Anal 9:2–12CrossRefGoogle Scholar
  41. 41.
    Ayet G, Burbano C, Cuadrado C, Pedrosa MM, Robredo LM, Muzquiz M, de la Cuadra C, Castaño A, Osagie A (1997) Effect of germination, under different environment conditions, on saponins, phytic acid and tannins in lentils (Lens culinaris). J Sci Food Agric 74:273–279CrossRefGoogle Scholar
  42. 42.
    Güçlü-Üstündağ Ö, Mazza G (2007) Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 47:231–258CrossRefGoogle Scholar
  43. 43.
    Mejia EGL, Prisecaru VI (2005) Lectins as bioactive plant proteins: a potential in cancer treatment. Crit Rev Food Sci Nutr 45:425–445CrossRefGoogle Scholar
  44. 44.
    Freier TC, Rudiger HEF (1990) Lectin-binding proteins from lentil seeds as mitogens for murine B-lymphocytes. Phytochemistry 29:1459–1461CrossRefGoogle Scholar
  45. 45.
    Finkina KI, Shramova EI, Tagaev AA, Ovchinnikova TV (2008) A novel defensin from the lentil (Lens culinaris) seeds. Biochem Biophys Res Commun 371:860–865CrossRefGoogle Scholar
  46. 46.
    Guillamon E, Pedrosa MM, Burbano C, Cuadrado C, Sanchez MC, Muzquiz M (2008) The trypsin inhibitors present in seed of different grain legume species and cultivars. Food Chem 107:68–74CrossRefGoogle Scholar
  47. 47.
    Cheung AHK, Ng TB (2007) Isolation and characterization of a trypsin–chymotrypsin inhibitor from the seeds of green lentil (Lens culinaris). Protein Pep Lett 14:859–864CrossRefGoogle Scholar
  48. 48.
    Scarafoni A, Magni C, Duranti M (2007) Molecular nutraceutics as a mean to investigate the positive effects of legume seed proteins on human health. Trends Food Sci Technol 18:454–463CrossRefGoogle Scholar
  49. 49.
    Lajolo FM, Genovese M (2002) Nutritional significance of lectins and enzyme inhibitors from legumes. J Agric Food Chem 50:6592–6598CrossRefGoogle Scholar
  50. 50.
    Costa GEA, Queiroz-Monici KS, Reis SMP, Oliveira MAC (2006) Chemical composition, dietary fibre and resistant starch contents of raw and cooked pea, common bean, chickpea and lentil legumes. Food Chem 94:327–330CrossRefGoogle Scholar
  51. 51.
    Stephen AM, Dahl WJ, Sieber GM, Blaricom JA, Morgan DR (1995) Effect of green lentils on colonic function, nitrogen balance, and serum lipids in healthy human subjects. Am J Clin Nutr 62:1–7Google Scholar
  52. 52.
    Perera A, Meda V, Tyler RT (2010) Resistant starch: a review of analytical protocols for determining resistant starch and of factors affecting the resistant starch content of foods. Food Res Int 43:1959–1974CrossRefGoogle Scholar
  53. 53.
    Garcia-Alonso A, Goni I, Saura-Calixto F (1998) Resistant starch and potential glycaemic index of raw and cooked legumes (lentils, chickpeas and beans). Z Lebensm Unters Forsch A 206:284–287CrossRefGoogle Scholar
  54. 54.
    Queiroz-Monici KS, Costa GEA, Silva N, Reis SM, Oliveira AC (2005) Bifidogenic effect of dietary fibre and resistant starch from leguminous on the intestinal microbiota of rats. Nutr 21:602–608CrossRefGoogle Scholar
  55. 55.
    Hernandez-Salazar M, Osorio-Diaz P, Loarca-Pina G, Reynoso-Camacho R, Tovar J, Bello-Pérez LA (2010) In vitro fermentability and antioxidant capacity of the indigestible fraction of cooked black beans (Phaseolus vulgaris L.), lentils (Lens culinaris L.) and chickpeas (Cicer arietinum L.). J Sci Food Agric 90:1417–1422CrossRefGoogle Scholar
  56. 56.
    Pellegrini N, Serafini M, Salvatore S, Rio DD, Bianchi M, Brighenti F (2006) Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. Mol Nutr Food Res 50:1030–1038CrossRefGoogle Scholar
  57. 57.
    Xu BJ, Chang SKC (2008) Effect of soaking, boiling, and steaming on total phenolic content and antioxidant activities of cool season food legumes. Food Chem 110:1–13CrossRefGoogle Scholar
  58. 58.
    USDA Database for the Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods, Release2.Retreivablefrom (accessed October 2010)
  59. 59.
    Lardos A (2006) The botanical materia medica of the Iatrosophikon-A collection of prescriptions from a monastery in Cyprus. J Ethnopharmacol 104:387–406CrossRefGoogle Scholar
  60. 60.
    Giday M, Teklehaymanot T, Animut A, Mekonnen Y (2007) Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in Northwest Ethiopia. J Ethnopharmacol 110:516–525CrossRefGoogle Scholar
  61. 61.
    Teklehaymanot T, Giday M, Medhin G, Mekonnen Y (2007) Knowledge and use of medicinal plants by people around Debre Libanos monastery in Ethiopia. J Ethnopharmacol 111:271–283CrossRefGoogle Scholar
  62. 62.
    Sezik E, Yesilada E, Honda G, Takaishi Y, Takeda Y, Tanaka T (2001) Traditional medicine in Turkey X. Folk medicine in Central Anatolia. J Ethnopharmacol 75:95–115CrossRefGoogle Scholar
  63. 63.
    Alexandre KB, Gray ES, Lambson BE, Moore PL, Choge IA, Mlisana K, Abdool Karim SS, McMahon J, OKeefe Chikwamba R, Morris L, Chikwamba R, Morris L (2010) Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins– Griffithsin– Cyanovirin-N and Scytovirin. Virology 402:187–196CrossRefGoogle Scholar
  64. 64.
    Kingman SM, Walker AF, Low AG, Sambrook IE (1993) Comparative effect of four legume species on plasma lipids and fecal steroid excretion in hypocholesterolaemic pigs. Br J Nutr 69:409–421CrossRefGoogle Scholar
  65. 65.
    Flight I, Clifton P (2006) Cereal grains and legumes in the prevention of coronary heart disease and stroke: a review of the literature. Eur J Clin Nutr 60:1145–1159CrossRefGoogle Scholar
  66. 66.
    Anderson JW, Major AW (2002) Pulses and lipemia, short- and long-term effect: potential in the prevention of cardiovascular disease. Br J Nutr 88:S263–S271CrossRefGoogle Scholar
  67. 67.
    Boye JI, Roufik S, Pesta N, Barbana C (2010) Angiotensin I-converting enzyme inhibitory properties and SDS-PAGE of red lentil protein hydrolysates. LWT-Food Sci Technol 43:987–991CrossRefGoogle Scholar
  68. 68.
    Tucker KL, Selhub J, Wilson PWF, Rosenberg IH (1996) Dietary intake pattern relates to plasma folate and homocysteine concentrations in the Framingham heart study. J Nutr 126:3025–3031Google Scholar
  69. 69.
    Pinto X, Vilaseca MA, Balcells S, Artuch R, Corbella E, Meco JF, Vila R, Pujol R, Grinberg D (2005) Folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations. Int J Med Sci 2:58–63CrossRefGoogle Scholar
  70. 70.
    Al-Tibi AMH, Takruri HR, Ahmad MN (2010) Effect of dehulling and cooking of lentils (Lens culinaris L.) on serum glucose and lipoprotein levels in streptozotocin-induced diabetic rats. Malays J Nutr 16:83–92Google Scholar
  71. 71.
    Eidi A, Eidi M (2009) Antidiabetic effects of sage (Salvia officinalis L.) leaves in normal and streptozotocin-induced diabetic rats. Diabetes Metabol Synd: Clin Res Rev 3:40–44CrossRefGoogle Scholar
  72. 72.
    Martins JM, Riottot M, de Abreu MC, Lança MJ, Viegas-Crespo AM, Almeida JA, Freire JB, Bento OP (2004) Dietary raw peas (Pisum sativum L.) reduce plasma total and LDL cholesterol and hepatic esterified cholesterol in intact and ileorectal anastomosed pigs fed cholesterol-rich diets. J Nutr 134:3305–3312Google Scholar
  73. 73.
    Shams H, Tahbaz F, Entezari M, Abadi A (2008) Effects of cooked lentils on glycaemic control and blood lipids of patients with type 2 diabetes. ARYA Athero J 3:215–218Google Scholar
  74. 74.
    Jenkins DJA, Wong GS, Patten R, Bird J, Hall M, Buckley GC, McGuire V, Reichert R, Little JA (1983) Leguminous seeds in the dietary management of hyperlipidemia. Am J Clin Nutr 38:567–573Google Scholar
  75. 75.
    Dabai FD, Walker AF, Sambrook IE, Welch VA, Owen RW, Abeyasekera S (1996) Comparative effects on blood lipids and fecal steroids of five legume species incorporated into a semi-purified, hypercholesterolaemic rat diet. Br J Nutr 75:557–571CrossRefGoogle Scholar
  76. 76.
    Duane WC (1997) Effects of legume consumption on serum cholesterol, biliary lipids, and sterol metabolism in humans. J Lipid Res 38:1120–1128Google Scholar
  77. 77.
    Kingman SM (1991) The influence of legume seeds on human plasma lipid concentrations. Nutr Res Rev 4:97–123CrossRefGoogle Scholar
  78. 78.
    Bazzano LA, Thompson, Tees MT, Nguyen CH, Winham DM (2009) Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 21:94–103Google Scholar
  79. 79.
    Rizkalla SW, Bellisle F, Slama G (2002) Health benefits of low glycaemic index foods, such as pulses, in diabetic patients and healthy individuals. Br J Nutr 88:S255–S262CrossRefGoogle Scholar
  80. 80.
    Venn BJ, Mann JI (2004) Cereal grains, legumes and diabetes. Eur J Clin Nutr 58:1443–1461CrossRefGoogle Scholar
  81. 81.
    Calle-Pascual AL, Marenco G, Asis MJ, Bordiu E, Romeo S, Martin PJ, Maranes JP, Charro AL (1986) Effects of different proportions of carbohydrates, polysaccharides/monosaccharides, and different fibers on the metabolic control in diabetic rats. Metabolism 35:919–923CrossRefGoogle Scholar
  82. 82.
    Wolever TMS, Katzman-Relle L, Jenkins AL, Vuksna V, Josse RG, Jenkins DJA (1994) Glycaemic index of 102 complex carbohydrate foods in patients with diabetes. Nutr Res 14:651–669CrossRefGoogle Scholar
  83. 83.
    Jenkins DJA, Thorne MJ, Camelon K, Jenkins A, Rao AV, Taylor RH, Thompson LU, Kalmusky J, Reichert R, Francis T (1982) Effect of processing on digestibility and the blood glucose response: a study of lentils. Am J Clin Nutr 36:1093–1101Google Scholar
  84. 84.
    Jenkins DJA, Wolever TMS, Taylor RH, Barker H, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff DV (1981) Glycaemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34:362–366Google Scholar
  85. 85.
    Foster-Powell K, Holt SH, Brand-Miller JC (2002) International table of glycaemic index and glycaemic load values. Am J Clin Nutr 76:5–56Google Scholar
  86. 86.
    Hodge AM, Englsih DR, O’dea K, Giles GG (2004) Glycaemic index and dietary fibre and the risk of type 2 diabetes. Diabetes Care 27:2701–2706CrossRefGoogle Scholar
  87. 87.
    Araya A, Contreras P, Alvina M, Vera G, Pak N (2002) Comparison between an in vitro method to determine carbohydrate digestion rate and the glycaemic response in young men. Eur J Clin Nutr 56:735–739CrossRefGoogle Scholar
  88. 88.
    Germaine KA, Samman S, Fryirs CG, Griffiths PJ, Johnson SK, Quail KJ (2008) Comparison of in vitro starch digestibility methods for predicting the glycaemic index of grain foods. J Sci Food Agric 88:652–658CrossRefGoogle Scholar
  89. 89.
    Chung HJ, Liu Q, Hoover R, Tom D, Warkentin C, Vandenberg A (2008) In vitro starch digestibility, expected glycaemic index, and thermal and pasting properties of flours from pea, lentil and chickpea cultivars. Food Chem 111:316–321CrossRefGoogle Scholar
  90. 90.
    Mollard RC, Zykus A, Luhovyy BL, Nunez MF, Wong CL, Anderson GH (2011) The acute effects of a pulse-containing meal on glycaemic responses and measures of satiety and satiation within and at a later meal. Br J Nutr 108:509–517Google Scholar
  91. 91.
    McCrory MA, Hamaker BR, Lovejoy JC, Eichelsdoerfer PE (2010) Pulse consumption, satiety, and weight management. Adv Nutr 1:17–30CrossRefGoogle Scholar
  92. 92.
    Correa P (1981) Epidemiological correlations between diet and cancer frequency. Cancer Res 41:3685–3690Google Scholar
  93. 93.
    Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD (2005) Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Int J Cancer 114:628–633CrossRefGoogle Scholar
  94. 94.
    Akcicek E, Otles S, Esiyok D (2005) Cancer and its prevention by some horticultural and field crops in Turkey. Asian Pacific J Cancer Prev 6:224–230Google Scholar
  95. 95.
    Agurs-Collins T, Smoot D, Afful J, Makambi K, Adams-Campbell LL (2006) Legume intake and reduced colorectal adenoma risk in African–Americans. J Natl Black Nurses Assoc 17:6–12 (Abstract)Google Scholar
  96. 96.
    Bruce WR, Giacca A, Medline A (2000) Possible mechanisms relating diet and risk of colon cancer. Cancer Epidemiol Biomarkers Prev 9:1271–1279Google Scholar
  97. 97.
    Nichenametla SN, Taruscio TG, Barney DL, Exon JH (2006) A review of the effects and mechanisms of polyphenolics in cancer. Crit Rev Food Sci Nutr 46:161–183CrossRefGoogle Scholar
  98. 98.
    Losso JN (2008) The biochemical and functional food properties of the Bowman–Birk inhibitor. Crit Rev Food Sci Nutr 4:94–118CrossRefGoogle Scholar
  99. 99.
    Kennedy AR (1998) The Bowman–Birk inhibitor from soybeans as an anticarcinogenic agent. Am J Clin Nutr 68:1406S–1412SGoogle Scholar
  100. 100.
    Armstrong WB, Kennedy AR, Wan XS, Taylor TH, Nguyen QA, Jensen J, Thompson W, Lagerberg W, Meyskens FL (2000) Single-dose administration of Bowman–Birk inhibitor concentrates in patients with oral leukoplakia. Cancer Epidemiol Biomarkers Prev 9:43–47Google Scholar
  101. 101.
    Milner JA, McDonald SS, Anderson DE, Greenwald P (2001) Molecular targets for nutrients involved with cancer prevention. Nutr Cancer 41:1–16Google Scholar
  102. 102.
    Greenwald P, Clifford CK, Milner JA (2001) Diet and cancer prevention. Eur J Cancer 37:948–965CrossRefGoogle Scholar
  103. 103.
    Chen C, Kong ANT (2005) Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 26:318–326CrossRefGoogle Scholar
  104. 104.
    Gescher AJ, Sharma RA, Steward WP (2001) Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol 2:371–379CrossRefGoogle Scholar
  105. 105.
    Marks G, Aydos RDA, Fagundes DJ, Pontes ERJC, Takita LC, Amaral EGAS, Rossini A, Ynouye AM (2006) Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats. Acta Cirúrgica Brasileira 21:51–56CrossRefGoogle Scholar
  106. 106.
    Verghese M, Rao DR, Chawana CB, Walker LT, Shackelford L (2006) Anticarcinogenic effect of phytic acid (IP6): apoptosis as a possible mechanism of action. LWT-Food Sci Technol 39:1093–1098CrossRefGoogle Scholar
  107. 107.
    Vucenik I, Shamsuddin AM (2006) Protection against cancer by dietary IP6 and inositol. Nutr Cancer 55:109–125CrossRefGoogle Scholar
  108. 108.
    Gurfinkel DM, Rao AV (2003) Soyasaponins: the relationship between chemical structure and colon anticarcinogenic activity. Nutr Cancer 47:24–33CrossRefGoogle Scholar
  109. 109.
    Shomaf MS, Takruri HR, Faris MAIE (2012) Lentils (Lens culinaris L.) inhibit azoxymethane-induced colonic lesions and neoplasms in male Fischer 344 rats. Jordan Med J 45:231–239Google Scholar
  110. 110.
    Faris MAIE, Takruri HR, Shomaf MS, Bustanji YK (2009) Chemopreventive effect of raw and cooked lentils (Lens culinaris L) and soybeans (Glycine max) against azoxymethane-induced aberrant crypt foci. Nutr Res 29:355–362CrossRefGoogle Scholar
  111. 111.
    Talalay P (1998) Mechanisms of induction of enzymes that protect against chemical carcinogenesis. Adv Enzyme Regul 28:237–250CrossRefGoogle Scholar
  112. 112.
    Pool-Zobel B, Veeriah S, Bohmer FD (2005) Modulation of xenobiotic metabolizing enzymes by anticarcinogens-focus on glutathione-S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis. Mutat Res 591:74–92CrossRefGoogle Scholar
  113. 113.
    Khatiwada J, Verghese M, Walker LT, Shackelford L, Chawan CB, Sunkara R (2006) Combination of green tea, phytic acid, and inositol reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats. LWT- Food Sci Technol 39:1080–1086CrossRefGoogle Scholar
  114. 114.
    Arthur JR, McKenzie RC, Beckett GJ (2003) Selenium in the immune system. J Nutr 133:1457S–1459SGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Mo’ez Al-Islam Ezzat Faris
    • 1
    • 2
    Email author
  • Hamed Rabah Takruri
    • 3
  • Ala Yousef Issa
    • 4
  1. 1.Department of Clinical Nutrition, College of Applied Medical SciencesUniversity of HailHailSaudi Arabia
  2. 2.Department of NutritionFaculty of Pharmacy and Medical Sciences, Petra UniversityAmmanJordan
  3. 3.Department of Nutrition and Food TechnologyFaculty of Agriculture, The University of JordanAmmanJordan
  4. 4.Department of Clinical Pharmacy and BiopharmaceuticsFaculty of Pharmacy, The University of JordanAmmanJordan

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